α-Synuclein in Lewy bodies
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Parkinson's disease is a progressive fatal neurological disorder of aging that profoundly impairs control of body movements due to loss of dopaminergic neurons in the substantia nigra, which exhibit abnormal accumulation of α-synuclein fibrils in their cell body and neurites.
“PD is a progressive fatal neurological disorder of aging that profoundly impairs one’s ability to control body movements as the result of loss of dopaminergic neurons in the substantia nigra, which exhibit abnormal accumulation of α-synuclein fibrils in their cell body and neurites (Kam et al., 2018; Spillantini et al., 1997).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Spillantini et al., 1997
Parkinson's disease is characterized by the loss of nigrostriatal dopamine neurons and the formation of intracellular Lewy bodies, which consist primarily of α-synuclein and ubiquitin.
“Parkinson’s disease (PD), the most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons and the formation of intracellular Lewy bodies (LBs), which consist primarily of α-synuclein (hereafter referred to as synuclein) and ubiquitin1.”
From Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice (2018) · cites this paper as [1]
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- Authors
- Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M.
- Affiliations
- University of Cambridge (GB)
- University of Pennsylvania (US)
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Nature
- Published
- 1997-08-28
- Volume
- 388
- Issue
- 6645
- Pages
- 839-840
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1527671059
- Cited by
- 8,382
- References
- 2
- Citations by year
- 2026: 362 · 2025: 489 · 2024: 481 · 2023: 417 · 2022: 529 · 2021: 450 · 2020: 543 · 2019: 441 · 2018: 407 · 2017: 402 · 2016: 333 · 2015: 296 · 2014: 286 · 2013: 283 · 2012: 283
- FWCI
- 73.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- alpha-synuclein, Lewy bodies, Parkinson's disease, dementia with Lewy bodies, presynaptic proteins, neurodegeneration, neurofilaments, ubiquitin
- MeSH terms
- Humans, Immunohistochemistry, Nerve Tissue Proteins, Parkinson Disease, Lewy Bodies, Synucleins, alpha-Synuclein
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