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Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions
Abstract
The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed a PEGylated manganese‐based SAE (Mn/PSAE) by coordination of single‐atom manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion of cellular H 2 O 2 to.OH through a Fenton‐like reaction; it also promotes the decomposition of H 2 O 2 to O 2 and continuously catalyzes the conversion of O 2 to cytotoxic.O 2−via oxidase‐like activity. The catalytic activity of Mn/PSAE is more pronounced in the weak acidic tumor environment; therefore, these cascade reactions enable the sufficient generation of reactive oxygen species (ROS) and effectively kill tumor cells. The prominent photothermal conversion property of the amorphous carbon can be utilized for photothermal therapy. Hence, Mn/PSAE exhibits significant therapeutic efficacy through tumor microenvironment stimulated generation of multiple ROS and photothermal activity.
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Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Structural absorption by barbule microstructures of super black bird of paradise feathers
McCoy, D. E., Feo, T., Harvey, T. A., & Prum, R. O. (2018) · Nature Communications · doi:10.1038/s41467-017-02088-w · Cited by 7,424
Metalloproteins and metal sensing
Waldron, K. J., Rutherford, J. C., Ford, D., & Robinson, N. J. (2009) · Nature · doi:10.1038/nature08300 · Cited by 1,269
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Strategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 284
Defect engineering in nanozymes
Wu, Y., Xu, W., Jiao, L., Tang, Y., Chen, Y., Gu, W., & Zhu, C. (2022) · Materials Today · doi:10.1016/j.mattod.2021.10.032 · Cited by 269
Self-citationDong, C., Dai, X., Wang, X., Lu, Q., Chen, L., Song, X., Ding, L., Huang, H., Feng, W., Chen, Y., et al. (2022) · Advanced Materials · doi:10.1002/adma.202205680 · Cited by 130
Metadata
- Authors
- Zhu, Y., Wang, W., Cheng, J., Qu, Y., Dai, Y., Liu, M., Yu, J., Wang, C., Wang, H., Wang, S., Zhao, C., Wu, Y., & Liu, Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-03-11
- Volume
- 60
- Issue
- 17
- Pages
- 9480-9488
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3128836147
- Cited by
- 468
- References
- 4
- FWCI
- 24.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhu, Y., Wang, W., Cheng, J., Qu, Y., Dai, Y., Liu, M., Yu, J., Wang, C., Wang, H., Wang, S., Zhao, C., Wu, Y., & Liu, Y. (2021). Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202017152
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