The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen
Abstract
Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near‐infrared (NIR‐II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death‐ligand 1 (PD‐L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.
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Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationAggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014) · Advanced Materials · doi:10.1002/adma.201401356 · Cited by 3,405
Self-citationAggregation‐Induced Emission: New Vistas at the Aggregate Level
Zhao, Z., Zhang, H., Lam, J. W. Y., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201916729 · Cited by 1,442
Self-citationLin, H., Gao, S., Dai, C., Chen, Y., & Shi, J. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b07818 · Cited by 1,406
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 976
Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941
Design of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 809
Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics
Liu, S., Zhou, X., Zhang, H., Ou, H., Lam, J. W. Y., Liu, Y., Shi, L., Ding, D., & Tang, B. Z. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13889 · Cited by 647
Self-citation1D Coordination Polymer Nanofibers for Low‐Temperature Photothermal Therapy
Yang, Y. P., Zhu, W., Dong, Z., Chao, Y., Xu, L., Chen, M., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201703588 · Cited by 585
Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance
Yang, Q., Hu, Z., Zhu, S., Ma, R., Ma, H., Ma, Z., Wan, H., Zhu, T., Jiang, Z., Liu, W., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10334 · Cited by 554
Research works printed but not linked: 1
- Yu Y., 2021, Adv. Mater., 33, 2105976
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NIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 397
Self-citationTang, Y., Bisoyi, H. K., Chen, X., Liu, Z., Chen, X., Zhang, S., & Li, Q. (2023) · Advanced Materials · doi:10.1002/adma.202300232 · Cited by 214
Lee, K., Gao, Y., Wei, W., Tan, J., Wan, Y., Feng, Z., Zhang, Y., Liu, Y., Zheng, X., Cao, C., et al. (2023) · Advanced Materials · doi:10.1002/adma.202211632 · Cited by 182
J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores
Hu, X., Zhu, C., Sun, F., Chen, Z., Zou, J., Chen, X. S., & Yáng, Z. (2023) · Advanced Materials · doi:10.1002/adma.202304848 · Cited by 182
Qin, Y., Chen, X., Gui, Y., Wang, H., Tang, B. Z., & Wang, D. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03895 · Cited by 162
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Metadata
- Authors
- Yan, D., Wang, M., Wu, Q., Niu, N., Li, M., Song, R., Rao, J., Kang, M., Zhang, Z., Zhou, F., Wang, D., & Tang, B. Z.
- Affiliations
- Shenzhen University (CN)
- Hainan University (CN)
- Chinese University of Hong Kong (HK)
- Corresponding author
- Zhou, Feifan
- Wang, Dong
- Tang, Ben Zhong
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2022-05-05
- Volume
- 61
- Issue
- 27
- Pages
- e202202614-e202202614
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W4221090070
- Cited by
- 187
- References
- 50
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 64 · 2023: 48 · 2022: 19
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Postdoctoral Research Foundation of China (2019M663030)
- National Natural Science Foundation of China (52122317, 22175120, 21788102, 82171990)
- Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (2020B1515020011)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Keywords
- photothermal immunotherapy, aggregation-induced emission, theranostic nanoparticles, benzo[c]thiophene, fluorescence imaging, photoacoustic imaging, photothermal imaging, abscopal effect, PD-L1 inhibitors, metastasis, tumor recurrence, multimodal imaging
- MeSH terms
- Theranostic Nanomedicine, Humans, Immunotherapy, Neoplasms, Phototherapy, Cell Line, Tumor, Nanoparticles, Photoacoustic Techniques, Multimodal Imaging
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