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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen
Abstract
Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near‐infrared (NIR‐II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death‐ligand 1 (PD‐L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.
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Metadata
- Authors
- Yan, D., Wang, M., Wu, Q., Niu, N., Li, M., Song, R., Rao, J., Kang, M., Zhang, Z., Zhou, F., Wang, D., & Tang, B. Z.
- Affiliations
- Shenzhen University (CN)
- Hainan University (CN)
- Chinese University of Hong Kong (HK)
- Corresponding author
- Zhou, Feifan
- Wang, Dong
- Tang, Ben Zhong
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2022-05-05
- Volume
- 61
- Issue
- 27
- Pages
- e202202614-e202202614
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W4221090070
- Cited by
- 187
- References
- 50
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 64 · 2023: 48 · 2022: 19
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Postdoctoral Research Foundation of China (2019M663030)
- National Natural Science Foundation of China (52122317, 22175120, 21788102, 82171990)
- Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (2020B1515020011)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Keywords
- photothermal immunotherapy, aggregation-induced emission, theranostic nanoparticles, benzo[c]thiophene, fluorescence imaging, photoacoustic imaging, photothermal imaging, abscopal effect, PD-L1 inhibitors, metastasis, tumor recurrence, multimodal imaging
- MeSH terms
- Theranostic Nanomedicine, Humans, Immunotherapy, Neoplasms, Phototherapy, Cell Line, Tumor, Nanoparticles, Photoacoustic Techniques, Multimodal Imaging
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