The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy
Abstract
Although zeolitic imidazolate framework‐8 (ZIF‐8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF‐8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase‐1/gasdermin D (GSDMD)‐dependent pathway. The pyroptotic cell death is accompanied by necrosis and immunogenic cell death (ICD) simultaneously for efficient in situ immunity initiation. Meanwhile, carbonyl cyanide m‐chlorophenyl hydrazone (CCCP), a mitochondrial depolarizing agent, is successfully loaded into ZIF‐8 NPs and found to further enhance the pyroptosis process. Collectively, the obtained Pluronic F127‐modified CCCP‐incorporated ZIF‐8 NPs (F127 ZIF‐8 CCCP NPs) activate antitumor immunity and reprogram immunosuppressive tumor microenvironment (TME), realizing high‐efficiency tumor growth inhibition. This work will facilitate biomedicine applications of ZIF‐8 and provide good inspiration for pyroptosis‐induced cancer therapy.
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1 retracted
Cai, X., Xie, Z., Ding, B., Shao, S., Liang, S., Pang, M., & Lin, J. (2019) · Advanced Science · doi:10.1002/advs.201900848 · Cited by 213
Self-citationRetractedImmunogenic cell death and DAMPs in cancer therapy
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Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity
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Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules
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A bioorthogonal system reveals antitumour immune function of pyroptosis
Wang, Q., Wang, Y., Ding, J., Wang, C., Zhou, X., Gao, W., Huang, H., Shao, F., & Liu, Z. (2020) · Nature · doi:10.1038/s41586-020-2079-1 · Cited by 1,083
Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy
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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
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Self-citationGasdermin D pore structure reveals preferential release of mature interleukin-1
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Cited by
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373
Self‐Reinforced MOF‐Based Nanogel Alleviates Osteoarthritis by Long‐Acting Drug Release
Sun, Y., Ding, S., Zhao, X., Sun, D., Yang, Y., Chen, M., Zhu, C., Jiang, B., Gu, Q., Liu, H., et al. (2024) · Advanced Materials · doi:10.1002/adma.202401094 · Cited by 96
Metadata
- Authors
- Ding, B., Chen, H., Tan, J., Meng, Q., Zheng, P., Ma, P., & Lin, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2023-01-31
- Volume
- 62
- Issue
- 10
- Pages
- e202215307-e202215307
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W4315620714
- Cited by
- 348
- References
- 49
- FWCI
- 25.53
- Type
- journal article
- Language
- en
- Open access
- closed
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