The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules
Open accessAbstract
Enhancing the robustness of functional biomacromolecules is a critical challenge in biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical processing and biostorage. Here we report a novel method, inspired by natural biomineralization processes, which provides unprecedented protection of biomacromolecules by encapsulating them within a class of porous materials termed metal-organic frameworks. We show that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules. The resulting biocomposite is stable under conditions that would normally decompose many biological macromolecules. For example, urease and horseradish peroxidase protected within a metal-organic framework shell are found to retain bioactivity after being treated at 80 °C and boiled in dimethylformamide (153 °C), respectively. This rapid, low-cost biomimetic mineralization process gives rise to new possibilities for the exploitation of biomacromolecules.
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Cites
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702
Controlling Mineral Morphologies and Structures in Biological and Synthetic Systems
Meldrum, F. C., & Cölfen, H. (2008) · Chemical Reviews · doi:10.1021/cr8002856 · Cited by 1,397
An Overview of Biomineralization Processes and the Problem of the Vital Effect
Weiner, S. (2003) · Reviews in Mineralogy and Geochemistry · doi:10.2113/0540001 · Cited by 1,022
Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Li, D., Yadav, A., Zhou, H., Roy, K., Thanasekaran, P., & Lee, C. (2024) · Global Challenges · doi:10.1002/gch2.202300244 · Cited by 437
Cheng, G., Li, W., Ha, L., Han, X., Hao, S., Wan, Y., Wang, Z., Dong, F., Zou, X., Mao, Y., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03584 · Cited by 371
Hollow carbon nanobubbles: monocrystalline MOF nanobubbles and their pyrolysis
Zhang, W., Jiang, X., Zhao, Y., Carné-Sánchez, A., Malgras, V., Kim, J., Kim, J. H., Wang, S., Liu, J., Jiang, J.-S., et al. (2017) · Chemical Science · doi:10.1039/c6sc04903f · Cited by 365
Metadata
- Authors
- Liang, K., Ricco, R., Doherty, C. M., Styles, M. J., Bell, S., Kirby, N., Mudie, S., Haylock, D., Hill, A. J., Doonan, C. J., & Falcaro, P.
- Venue
- Nature Communications
- Published
- 2015-06-04
- Volume
- 6
- Issue
- 1
- Pages
- 7240-7240
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2270881685
- Cited by
- 1,496
- References
- 3
- FWCI
- 32.85
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liang, K., Ricco, R., Doherty, C. M., Styles, M. J., Bell, S., Kirby, N., Mudie, S., Haylock, D., Hill, A. J., Doonan, C. J., & Falcaro, P. (2015). Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules. Nature Communications. https://doi.org/10.1038/ncomms8240
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