The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cyclic Peptides for Drug Development
Open accessAbstract
Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady stream of new drugs, with an average of around one cyclic peptide drug approved per year. Powerful technologies for screening random peptide libraries, and de novo generating ligands, have enabled the development of cyclic peptide drugs independent of naturally derived molecules and now offer virtually unlimited development opportunities. In this review, we feature therapeutically relevant cyclic peptides derived from nature and discuss the unique properties of cyclic peptides, the enormous technological advances in peptide ligand development in recent years, and current challenges and opportunities for developing cyclic peptides that address unmet medical needs.
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Citations
Cites
Contemporary strategies for peptide macrocyclization
White, C. J., & Yudin, A. K. (2011) · Nature Chemistry · doi:10.1038/nchem.1062 · Cited by 1,088
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Predicting the structures of cyclic peptides containing unnatural amino acids by HighFold2
Zhu, C., Cao, S., Shang, T., Guo, J., Su, A., Li, C., & Duan, H. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf202 · Cited by 13
Lin, H., Zhu, C., Shang, T., Zhu, N., Lin, K., Zhang, C., Shao, X., Wang, X., & Duan, H. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00896 · Cited by 10
Bolz, S. N., Schake, P., Stitz, C., & Schroeder, M. (2025) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2025.2557599 · Cited by 7
Murail, S., Sawmynaden, J., Zemirli, A., Jusot, M., Pietrucci, F., Chomilier, J., Tufféry, P., & Stratmann, D. (2025) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.5c01123 · Cited by 6
Wu, D., & Zou, Y. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c03236 · Cited by 3
Computational design of Bax-inhibiting peptides
Vlaar, T., Mayer, B., van der Heide, L., & Ilie, I. M. (2025) · Materials Advances · doi:10.1039/d4ma01142b · Cited by 2
Development and structure-guided characterization of a novel ACE2-binding macrocyclic peptide
Benoit, R. M., Wang, J., Beyer, D., Abbas, A., Rodrigues, M. J., Wieser, M. M., Deupi, X., Müller, C., Suga, H., & Bode, J. W. (2026) · Journal of Structural Biology: X · doi:10.1016/j.yjsbx.2026.100145
Metadata
- Authors
- Ji, X., Nielsen, A. L., & Heinis, C.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2023-10-23
- Volume
- 63
- Issue
- 3
- Pages
- e202308251-e202308251
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W4387865628
- Cited by
- 411
- References
- 1
- FWCI
- 30.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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