Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Open accessAbstract
The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. The integration of novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering advancements, and artificial intelligence have significantly expedited the development of groundbreaking peptide-based drugs, effectively addressing the obstacles associated with their character, such as the rapid clearance and degradation, necessitating subcutaneous injection leading to increasing patient discomfort, and ultimately advancing translational research efforts. Peptides are presently employed in the management and diagnosis of a diverse array of medical conditions, such as diabetes mellitus, weight loss, oncology, and rare diseases, and are additionally garnering interest in facilitating targeted drug delivery platforms and the advancement of peptide-based vaccines. This paper provides an overview of the present market and clinical trial progress of peptide-based therapeutics, delivery platforms, and vaccines. It examines the key areas of research in peptide-based drug development through a literature analysis and emphasizes the structural modification principles of peptide-based drugs, as well as the recent advancements in screening, design, and delivery technologies. The accelerated advancement in the development of novel peptide-based therapeutics, including peptide-drug complexes, new peptide-based vaccines, and innovative peptide-based diagnostic reagents, has the potential to promote the era of precise customization of disease therapeutic schedule.
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Flagged first, then by citations
- Authors
- Xiao, W., Jiang, W., Chen, Z., Huang, Y., Mao, J., Zheng, W., Hu, Y., & Shi, J.
- Affiliations
- University of Electronic Science and Technology of China (CN)
- Southwest Jiaotong University (CN)
- Tianjin University of Traditional Chinese Medicine (CN)
- Corresponding author
- Shi, Jianyou
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2025-03-05
- Volume
- 10
- Issue
- 1
- Pages
- 74-74
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC11880366
- OpenAlex
- W4408129349
- Cited by
- 449
- References
- 41
- Citations by year
- 2026: 325 · 2025: 124
- FWCI
- 36.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82073311)
- Department of Science and Technology of Sichuan Province (2022JDTD0025)
- Sichuan Traditional Chinese Medicine Administration
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- peptide therapeutics, peptide vaccine, peptide delivery systems, artificial intelligence in drug design, peptide degradation, subcutaneous injection, diabetes mellitus, weight loss, rare diseases, clinical trials
- MeSH terms
- Drug Development, Humans, Peptides, Vaccines, Drug Delivery Systems, Vaccines, Subunit
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