Dual‐Targeting Biomimetic Semiconducting Polymer Nanocomposites for Amplified Theranostics of Bone Metastasis
Open accessAbstract
Bone metastasis is a type of metastatic tumors that involves the spreads of malignant tumor cells into skeleton, and its diagnosis and treatment remain a big challenge due to the unique tumor microenvironment. We herein develop osteoclast and tumor cell dual‐targeting biomimetic semiconducting polymer nanocomposites (SPFeN OC ) for amplified theranostics of bone metastasis. SPFeN OC contain semiconducting polymer and iron oxide (Fe 3 O 4 ) nanoparticles inside core and surface camouflaged hybrid membrane of cancer cells and osteoclasts. The hybrid membrane camouflage enables their targeting to both metastatic tumor cells and osteoclasts in bone metastasis through homologous targeting mechanism, thus achieving an enhanced nanoparticle accumulation in tumors. The semiconducting polymer mediates near‐infrared (NIR) fluorescence imaging and sonodynamic therapy (SDT), and Fe 3 O 4 nanoparticles are used for magnetic resonance (MR) imaging and chemodynamic therapy (CDT). Because both cancer cells and osteoclasts are killed synchronously via the combinational action of SDT and CDT, the vicious cycle in bone metastasis is broken to realize high antitumor efficacy. Therefore, 4T1 breast cancer‐based bone metastasis can be effectively detected and cured by using SPFeN OC as dual‐targeting theranostic nanoagents. This study provides an unusual biomimetic nanoplatform that simultaneously targets osteoclasts and cancer cells for amplified theranostics of bone metastasis.
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The combined SDT-CDT approach using SPFeNOC effectively inhibits breast cancer bone metastases.
“This combined SDT-CDT approach effectively inhibits breast cancer bone metastases [126].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [126]
Extracellular vesicles and cell membrane-coated biomimetic nanomaterials show promise as clinically applicable nanocarriers, offering targeted delivery to tumor sites with minimal or no immunogenicity.
“In contrast, extracellular vesicles (EVs) and cell membrane-coated biomimetic nanomaterials show promise as clinically applicable nanocarriers, offering targeted delivery to tumor sites with minimal or no immunogenicity [57, 126, 134, 138, 143, 163–165].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [126]
Cites
Targeting drugs to tumours using cell membrane-coated nanoparticles
Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980 · see citing works
Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
Zhen, X., Cheng, P., & Pu, K. (2019) · Small · doi:10.1002/smll.201804105 · Cited by 483 · see citing works
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Nanosensitizer-assisted sonodynamic therapy for breast cancer
Yu, J., Hu, J.-R., Tian, Y., Lei, Y.-M., Hu, H.-M., Lei, B.-S., Zhang, G., Sun, Y., & Ye, H.-R. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03311-3 · Cited by 43 · see citing works
- Authors
- Zhang, Y., Wang, Y., Zhu, A., Yu, N., Xia, J., & Li, J.
- Affiliations
- Donghua University (CN)
- Songjiang District Central Hospital (CN)
- Corresponding author
- Xia, Jindong
- Li, Jingchao
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2023-12-06
- Volume
- 63
- Issue
- 2
- Pages
- e202310252-e202310252
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W4389070513
- Cited by
- 43
- References
- 2
- Citations by year
- 2026: 5 · 2025: 23 · 2024: 15
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Update notices
- correction (2026-01-30)
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Technology Commission of Shanghai Municipality (22ZR1401100, 22490760700, 23WZ2504600 and 23ZR1457400)
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- bone metastasis, theranostics, iron oxide nanoparticles, tumor cell targeting, biomimetic nanoplatform, homologous targeting, sonodynamic therapy, chemodynamic therapy, near-infrared fluorescence imaging, magnetic resonance imaging, 4T1 breast cancer, tumor microenvironment
- MeSH terms
- Theranostic Nanomedicine, Bone Neoplasms, Humans, Neoplasms, Polymers, Biomimetics, Cell Line, Tumor, Nanoparticles, Nanocomposites, Precision Medicine, Tumor Microenvironment
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