Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
Abstract
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation, and low accumulation in target sites. Cell‐membrane coating has emerged as a potential way to overcome these limitations, owing to the abundant proteins on the surface of cell membranes that can be inherited to the cell membrane–camouflaged nanoparticles. This review summarizes the recent advances in the development of biomimetic cell membrane–camouflaged nanoparticles for cancer phototherapy. Different sources of cell membranes can be used to coat nanoparticles uisng different coating approaches. After cell‐membrane coating, the photophysical properties of the original phototherapeutic nanoparticles remain nearly unchanged; however, the coated nanoparticles are equipped with additional physiological features including immune escape, in vivo prolonged circulation time, or homologous targeting, depending on the cell sources. Moreover, the coated cell membrane can be ablated from phototherapeutic nanoparticles under laser irradiation, leading to drug release and thus synergetic therapy. By combining other supplementary agents to normalize tumor microenvironment, cell‐membrane coating can further enhance the therapeutic efficacy against cancer.
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Conventional nanoparticles continue to face difficulties including quick blood circulation clearance, simple immune system recognition, and low target site accumulation.
“Conventional nanoparticles continue to face a number of difficulties, including quick blood circulation clearance, simple immune system recognition, and low target site accumulation.64”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [64]
Cell membrane coating has become recognized as a viable means of overcoming the limitations of conventional nanoparticles.
“Due to the numerous proteins that are present on the surface of cell membranes, cell membrane coating has become recognized as a viable means of overcoming these limitations.64,65”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [64]
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- Authors
- Zhen, X., Cheng, P., & Pu, K.
- Affiliations
- School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Singapore 637457 Singapore
- Nanyang Technological University (SG)
- Corresponding author
- Pu, Kanyi
- Venue
- Small
- Publisher
- Wiley
- Published
- 2018-11-20
- Volume
- 15
- Issue
- 1
- Pages
- e1804105-e1804105
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2900568353
- Cited by
- 483
- References
- 152
- Citations by year
- 2026: 13 · 2025: 38 · 2024: 60 · 2023: 94 · 2022: 90 · 2021: 78 · 2020: 77 · 2019: 33
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Funders
- Nanyang Technological University (NTUSUG: M4081627.120)
- Ministry of Education - Singapore (RG133/15 M4011559, 2015‐T1‐002‐091, MOE2016‐T2‐1‐098)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- biomimetic nanoparticles, cancer phototherapy, photothermal therapy, photodynamic therapy, immune evasion, homologous targeting, laser-triggered drug release, tumor microenvironment normalization, reactive oxygen species
- MeSH terms
- Animals, Cell Membrane, Humans, Neoplasms, Particle Size, Phototherapy, Nanoparticles, Static Electricity
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