Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, Ronnie H.; Gao, Weiwei; Zhang, Liangfang

doi:10.1038/s41571-022-00699-x

Cited by 980Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsExtracellular vesicles in disease

Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, Ronnie H., Gao, Weiwei, Zhang, Liangfang·2023·Nature Reviews Clinical Oncology

DOI 10.1038/s41571-022-00699-x

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Abstract

Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-specific nature, causing harm to non-malignant tissues. Over the past several decades, nanomedicine researchers have sought to address this challenge by developing nanoscale platforms capable of more precisely delivering drug payloads. Cell membrane-coated nanoparticles (CNPs) are an emerging class of nanocarriers that have demonstrated considerable promise for biomedical applications. Consisting of a synthetic nanoparticulate core camouflaged by a layer of naturally derived cell membranes, CNPs are adept at operating within complex biological environments; depending on the type of cell membrane utilized, the resulting biomimetic nanoformulation is conferred with several properties typically associated with the source cell, including improved biocompatibility, immune evasion and tumour targeting. In comparison with traditional functionalization approaches, cell membrane coating provides a streamlined method for creating multifunctional and multi-antigenic nanoparticles. In this Review, we discuss the history and development of CNPs as well as how these platforms have been used for cancer therapy. The application of CNPs for drug delivery, phototherapy and immunotherapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CNPs.

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Background
Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell
Diao, L., & Liu, M. (2023) · Advanced Science · doi:10.1002/advs.202300121 · Cited by 156 · see citing works
Advances and Prospects in Integrated Nano-oncology
Jiang, J., Cui, X., Huang, Y., Yan, D., Wang, B., Yang, Z., Chen, M., Wang, J., Zhang, Y., Liu, G., et al. (2024) · Nano Biomedicine and Engineering · doi:10.26599/nbe.2024.9290060 · Cited by 136 · see citing works
GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs
Ji, Q., Zhu, H., Qin, Y., Zhang, R., Wang, L., Zhang, E., Zhou, X., & Meng, R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1329636 · Cited by 133 · see citing works
“…the past decade, researchers have attempted to construct a number of drug delivery systems with biological activities, such as ferritin nanocarriers, cell membrane-coated drug carriers, and activated protein nanoparticles (Liang et al., 2014; Lee et al., 2016; He et al., 2019; Fang et al., 2023).”
Background
Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy
Zhuang, Z., Li, J., Shen, P., Zhao, Z., & Tang, B. Z. (2024) · Aggregate · doi:10.1002/agt2.540 · Cited by 131 · see citing works
Advancing engineering design strategies for targeted cancer nanomedicine
Gomerdinger, V. F., Nabar, N., & Hammond, P. T. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00847-2 · Cited by 154 · see citing works
“Thus, cell coating technology offers a versatile approach for imparting stealth, targeting and immunomodulatory properties onto nanoparticles; current efforts focus on improving scalability, batch-to-batch variability and quality analysis to make clinical translation possible 179 .”
Influential
Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers
Gao, X. J., Ciura, K., Ma, Y., Mikołajczyk, A., Jagiełło, K., Wan, Y., Gao, Y., Zheng, J., Zhong, S., Puzyn, T., et al. (2024) · Advanced Materials · doi:10.1002/adma.202407793 · Cited by 125 · see citing works
Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery
Wong, K., Nie, Z., Wong, M., Wang, Y., & Liu, J. (2024) · Advanced Materials · doi:10.1002/adma.202404053 · Cited by 123 · see citing works
Advances and applications of nanoparticles in cancer therapy
Huang, X., He, T., Liang, X., Xiang, Z., Liu, C., Zhou, S., Luo, R., Bai, L., Kou, X., Li, X., et al. (2024) · MedComm – Oncology · doi:10.1002/mog2.67 · Cited by 123 · see citing works
Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy
He, Y., Zhang, S., She, Y., Liu, Z., Zhu, Y., Cheng, Q., & Ji, X. (2024) · Exploration · doi:10.1002/exp.20230164 · Cited by 118 · see citing works
Engineering and Targeting Neutrophils for Cancer Therapy
Zhang, J., Gu, J., Wang, X., Ji, C., Yu, D., Wang, M., Pan, J., Santos, H. A., Zhang, H., & Zhang, X. (2024) · Advanced Materials · doi:10.1002/adma.202310318 · Cited by 114 · see citing works
Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment
Han, X., Gong, C., Yang, Q., Zheng, K., Wang, Z., & Zhang, W. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s442877 · Cited by 108 · see citing works
“230 The resulting formulations inherit the specific functions of the respective membranes, and the newly synthesized hybrid membranes are endowed with the corresponding functions by adjusting the ratio of the source membranes to achieve the organic integration of multiple functions into the same…”
Background
Mechanistic Understanding of Protein Corona Formation around Nanoparticles: Old Puzzles and New Insights
Nienhaus, K., & Nienhaus, G. U. (2023) · Small · doi:10.1002/smll.202301663 · Cited by 107 · see citing works
NIR‐II Photoacoustic Imaging‐Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma
Zeng, S., Chen, J., Gao, R., Chen, R., Xue, Q., Ren, Y., Liu, L., Tang, C., Hu, H., Zeng, N., et al. (2023) · Advanced Materials · doi:10.1002/adma.202308780 · Cited by 103 · see citing works
Polyethylene glycol immunogenicity in nanomedicine
Chen, Y., Su, Y.-C., & Roffler, S. R. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00321-6 · Cited by 113 · see citing works
Artificial Intelligence-Assisted Design of Nanomedicines for Breast Cancer Diagnosis and Therapy: Advances, Challenges, and Future Directions
Shirzad, M., Shaban, M., Mohammadzadeh, V., Rahdar, A., Fathi‐karkan, S., Hoseini, Z. S., Najafi, M., Kharaba, Z. J., & Aboudzadeh, M. A. (2025) · BioNanoScience · doi:10.1007/s12668-025-01980-w · Cited by 105 · see citing works
Engineered Living Materials for Advanced Diseases Therapy
Xue, D. Q., Wu, W. H., Pan, P., & Zhang, X. (2023) · Advanced Materials · doi:10.1002/adma.202304963 · Cited by 93 · see citing works
Tumor microenvironment targeted nano-drug delivery systems for multidrug resistant tumor therapy
Shao, X., Zhao, X., Wang, B., Fan, J., Wang, J., & An, H. (2025) · Theranostics · doi:10.7150/thno.103636 · Cited by 95 · see citing works
Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives
Shen, X., Pan, D., Gong, Q., Gu, Z., & Luo, K. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.10.017 · Cited by 96 · see citing works
“Cell membrane-encapsulated nanoparticles have become a novel class of nanocarriers with a core-shell structure [272].”
Background
Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier
Lim, S. H., Yee, G. T., & Khang, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s450853 · Cited by 92 · see citing works
“16,166 By combining NP-based strategies with other modalities, such as ultrasound-wave, magnetic field, or intranasal delivery, the synergistic effects can lead to improved drug penetration and therapeutic efficacy.”
Background
Advances and clinical challenges of mesenchymal stem cell therapy
Mei, R., Wan, Z., Yang, C., Shen, X., Wang, R., Zhang, H., Yang, R., Li, J., Song, Y., & Su, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1421854 · Cited by 90 · see citing works
Biomimetic design strategies for biomedical applications
Wei, X., Wang, Y., Liu, Y., Ji, K., Li, K., Wang, J., & Gu, Z. (2024) · Matter · doi:10.1016/j.matt.2023.12.030 · Cited by 89 · see citing works
Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy
Spano, D., & Catara, G. (2023) · Cells · doi:10.3390/cells13010029 · Cited by 85 · see citing works
“Another promising approach to targeted drug delivery is the use of cell membrane-coated nanoparticles (CNPs) [177], an emerging class of nanocarriers.”
Background
Lipid-based nanosystems: the next generation of cancer immune therapy
Cheng, Z., Fobian, S., Gurrieri, E., Amin, M., D’Agostino, V., Falahati, M., Zalba, S., Debets, R., Garrido, M. J., Saeed, M., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01574-1 · Cited by 90 · see citing works
“CMCNs may confer biocompatibility, immune-cell co-operation, targeting, and prolonged systemic circulation to lipid-based NPs by integrating cell membrane portions into or onto NPs or surfaces thereof [38, 329].”
Background
Bone-targeted biomimetic nanogels Re-establish osteoblast/osteoclast balance to treat postmenopausal osteoporosis
Cui, Y., Lv, B., Li, Z., Ma, C., Gui, Z., Geng, Y., Liu, G., Sang, L., Xu, C., Min, Q., et al. (2024) · Small · doi:10.1002/smll.202303494 · Cited by 81 · see citing works
Cancer Nanovaccines: Nanomaterials and Clinical Perspectives
Desai, N., Chavda, V. P., Singh, T. R. R., Thorat, N. D., & Vora, L. K. (2024) · Small · doi:10.1002/smll.202401631 · Cited by 80 · see citing works
Engineered Cell Membrane Coating Technologies for Biomedical Applications: From Nanoscale to Macroscale
An, Y., Ji, C., Zhang, H., Jiang, Q., Maitz, M. F., Pan, J., Luo, R., & Wang, Y. (2025) · ACS Nano · doi:10.1021/acsnano.4c16280 · Cited by 82 · see citing works
Supramolecularly Engineered Conjugate of Bacteria and Cell Membrane‐Coated Magnetic Nanoparticles for Enhanced Ferroptosis and Immunotherapy of Tumors
Xie, B., Zhao, H., Ding, Y., Wang, Z., Cheng, G., Li, S., Zhang, K., Ip, S. W., Yu, H., & Wang, R. (2023) · Advanced Science · doi:10.1002/advs.202304407 · Cited by 80 · see citing works
mRNA Cancer Vaccines: Construction and Boosting Strategies
Liu, X., Huang, P., Yang, R., & Deng, H. (2023) · ACS Nano · doi:10.1021/acsnano.3c05635 · Cited by 78 · see citing works
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1.
Yang, Z., Liu, X.-P., Zhu, J., Chai, Y.-Y., Cong, B., Li, B., Gao, W.-F., Hu, Y., Wen, M., Liu, Y., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.11.008 · Cited by 81 · see citing works
Self-citation
Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications
Wu, X., Hu, J., & Yoon, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202400249 · Cited by 77 · see citing works
Photoresponsive Drug Delivery Systems: Challenges and Progress
Yang, Y., Long, K., Chu, Y., Lu, H., Wang, W., & Zhan, C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402975 · Cited by 75 · see citing works
Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy
Zhou, L., Guan, Q., & Dong, Y. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202314763 · Cited by 73 · see citing works
Plant-derived exosome-like nanovesicles: A novel nanotool for disease therapy
Jin, Z., Na, J., Lin, X., Jiao, R., Liu, X., & Huang, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30630 · Cited by 72 · see citing works
“This integration retains the original biological characteristics of PELNVs and greatly enhances their drug-loading capacity [89,90].”
Background
Surface Engineering of Nanoparticles toward Cancer Theranostics
Huang, P., Wang, C., Deng, H., et al. (2023) · Accounts of Chemical Research · doi:10.1021/acs.accounts.3c00122 · Cited by 69 · see citing works
An Engineered Bionic Nanoparticle Sponge as a Cytokine Trap and Reactive Oxygen Species Scavenger to Relieve Disc Degeneration and Discogenic Pain
Yang, W., Li, K., Pan, Q. L., Huang, W., Xiao, Y., Lin, H., Liu, S., Chen, X., Lv, X., Feng, S., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c08097 · Cited by 69 · see citing works
Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy
Li, Z., Zhang, Q., Li, Z., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.02.006 · Cited by 69 · see citing works
“The branched polymers-derived nanostructures could be endowed with a homologous targeting ability after they are coated with tumor cell membranes to form biomimetic nanoparticles, thereby improving their homologous recognition by tumor cells 22,23 .”
Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy
Yang, M., Zhou, J., Lu, L., Deng, D., Huang, J., Tang, Z., Shi, X., Lo, P., Lovell, J. F., Zheng, Y., et al. (2024) · Exploration · doi:10.1002/exp.20230171 · Cited by 71 · see citing works
Cell membrane‐coated nanoparticles for the treatment of cancer
Krishnan, N., Fang, R. H., & Zhang, L. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1285 · Cited by 68 · see citing works
Self-citation
Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery
Wang, Q., Liu, Y., Li, C., Xu, S., Xu, S., & Liu, B. (2025) · Advanced Science · doi:10.1002/advs.202503138 · Cited by 76 · see citing works
Multiple Synergistic Effects of the Microglia Membrane-Bionic Nanoplatform on Mediate Tumor Microenvironment Remodeling to Amplify Glioblastoma Immunotherapy
Fan, Q., Kuang, L., Wang, F., Yin, Y., Dong, Z., Tian, N., Wang, J., Yin, T., & Wang, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c01253 · Cited by 66 · see citing works
Biomimetic Tumor Cell Membrane‐Encapsulated Nanoparticles Combine NIR‐II Photothermal Therapy and Chemotherapy for Enhanced Immunotherapy in Triple‐Negative Breast Cancer
Xiong, W., Cheng, Z., Chen, H., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202410841 · Cited by 64 · see citing works
Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects
Guillot, A. J., Martínez‐Navarrete, M., Zinchuk‐Mironova, V., & Melero, A. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1884 · Cited by 64 · see citing works
Bioinspired Sonodynamic Nano Spray Accelerates Infected Wound Healing via Targeting and Disturbing Bacterial Metabolism
Qian, X., Lu, T., Huang, C., Zheng, D., Gong, G., Chu, X., Wang, X., Lai, H., Ma, L., Jiang, L., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202315576 · Cited by 63 · see citing works
Exosome-based nanoparticles and cancer immunotherapy
Ye, J., Li, D., Jie, Y., Luo, H., Zhang, W., & Qiu, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117296 · Cited by 66 · see citing works
Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy
Cheng, Q., Kang, Y., Yao, B. W., Dong, J., Zhu, Y., He, Y., & Ji, X. (2023) · Advanced Science · doi:10.1002/advs.202302131 · Cited by 60 · see citing works
Bioengineered nanotechnology for nucleic acid delivery
Zhang, Y., Luo, J., Gui, X., Zheng, Y., Schaar, E., Liu, G., & Shi, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.034 · Cited by 61 · see citing works
Advances in Lipid-Polymer Hybrid Nanoparticles: Design Strategies, Functionalization, Oncological and Non-Oncological Clinical Prospects
Jacob, S., Varkey, N. R., Boddu, S. H. S., Gorain, B., Rao, R., & Nair, A. B. (2025) · Pharmaceuticals · doi:10.3390/ph18121772 · Cited by 61 · see citing works
“Similarly, biomimetic nanocarriers including cell membrane-coated nanoparticles and extracellular vesicle inspired hybrids offer superior immune evasion and prolonged circulation relative to conventional LPHNPs [196].”
Cancer Cell Membrane Nanodiscs for Antitumor Vaccination
Guo, Z., Noh, I., Zhu, A. T., Yu, Y., Gao, W., Fang, R. H., & Zhang, L. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c01775 · Cited by 60 · see citing works
Self-citation
Hybrid Cell Membrane‐Coated Nanoparticles for Biomedical Applications
Yu, Y., Peng, Y., Shen, W., et al. (2024) · Small Structures · doi:10.1002/sstr.202300473 · Cited by 60 · see citing works
Self-citation
Recent advances of engineering cell membranes for nanomedicine delivery across the blood–brain barrier
Yuan, S., Hu, D., Gao, D., Butch, C. J., Wang, Y., Zheng, H., & Sheng, Z. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03572-y · Cited by 63 · see citing works
“In contrast, membrane extraction from nucleated cells—such as tumor cells, macrophages, NK cells, and neutrophils—requires gradient centrifugation following cell lysis and homogenization [19].”
Influential
Cell membrane coated nanoparticles as a biomimetic drug delivery platform for enhancing cancer immunotherapy
Zhong, Z., Deng, W., Wu, J., Shang, H., Tong, Y., Yu, H., Huang, Q., Ba, X., Chen, Z., & Tang, K. (2024) · Nanoscale · doi:10.1039/d4nr00284a · Cited by 61 · see citing works
A Twindrive Precise Delivery System of Platelet-Neutrophil Hybrid Membrane Regulates Macrophage Combined with CD47 Blocking for Postoperative Immunotherapy
Sheng, S., Jin, L., Zhang, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c10862 · Cited by 58 · see citing works
Neutrophil‐Mimetic, ROS Responsive, and Oxygen Generating Nanovesicles for Targeted Interventions of Refractory Rheumatoid Arthritis
Tang, Z., Meng, S., Yang, X., et al. (2023) · Small · doi:10.1002/smll.202307379 · Cited by 57 · see citing works
Platelet-derived drug delivery systems: Pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond
Zhu, Y., Xu, L., Kang, Y., Cheng, Q., He, Y., & Ji, X. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122478 · Cited by 58 · see citing works
Spleen-targeted delivery systems and strategies for spleen-related diseases
Huang, Z., Sun, K., Luo, Z., Zhang, J., Zhou, H., Yin, H., Liang, Z., & You, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.007 · Cited by 56 · see citing works
A Homing Peptide Modified Neutrophil Membrane Biomimetic Nanoparticles in Response to ROS/inflammatory Microenvironment for Precise Targeting Treatment of Ischemic Stroke
Dong, Z., Tang, L., Zhang, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202309167 · Cited by 56 · see citing works
Homologous Tumor Targeting Molybdenum‐Doped Prussian Blue for Enhancing Immunotherapy via PTT/CDT and Remodeled Tumor Immune Microenvironment
Ma, S., Li, D., Jia, X., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402692 · Cited by 56 · see citing works
Targeted ROS Scavenging for Disease Therapies Using Nanomaterials
Zhang, Y., Zhang, Y., Liang, R., Zou, J., Pei, R., & Chen, X. S. (2025) · Advanced Materials · doi:10.1002/adma.202504435 · Cited by 60 · see citing works
Recent progress, perspectives, and issues of engineered PD-L1 regulation nano-system to better cure tumor: A review
Zhou, Z., Wang, H., Li, J., Jiang, X., Li, Z., & Shen, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127911 · Cited by 54 · see citing works
Cell membrane-based biomimetic technology for cancer phototherapy: Mechanisms, recent advances and perspectives
Li, S., Meng, X., Peng, B., Huang, J., Liu, J., Xiao, H., Li, M., Liu, Y., & Tang, J. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.11.029 · Cited by 54 · see citing works
Surface engineering of nanoparticles for precision medicine
Zheng, J., Sun, Y., Shen, Y., & Zhou, Z. (2025) · Precision medicine and engineering. · doi:10.1016/j.preme.2025.100037 · Cited by 54 · see citing works
Genetically engineered cellular nanoparticles for biomedical applications
Krishnan, N., Peng, F.-X., Mohapatra, A., Fang, R. H., & Zhang, L. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122065 · Cited by 54 · see citing works
Self-citation
In situ formed scaffold with royal jelly-derived extracellular vesicles for wound healing
Tan, D., Zhu, W., Liu, L., et al. (2023) · Theranostics · doi:10.7150/thno.84665 · Cited by 53 · see citing works
Nanovesicles for Lipid Metabolism Reprogram-Enhanced Ferroptosis and Magnetotherapy of Refractory Tumors and Inhibiting Metastasis with Activated Innate Immunity
Cheng, X.-Q., Xu, J., Cui, Y., Liu, J., Chen, Y., He, C., Cui, L., Liu, Y., Song, B., Gong, C., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c16981 · Cited by 53 · see citing works
Multifunctional Nanocarrier Drug Delivery Systems: From Diverse Design to Precise Biomedical Applications
Zhu, Y., He, M., Lin, C., Ma, W., Ai, Y., Wang, J., & Liang, Q. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502178 · Cited by 58 · see citing works
Redox‐Responsive Polymeric Nanoparticle for Nucleic Acid Delivery and Cancer Therapy: Progress, Opportunities, and Challenges
Xu, L., Cao, Y., Ya, X., Li, R., & Xu, X. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300238 · Cited by 53 · see citing works
Neutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage
Fan, L., Jin, L., Tang, T., Zheng, Y., Chen, Z., Lin, H., Ding, C., Wang, T., Chen, H., Guo, Y., et al. (2023) · Theranostics · doi:10.7150/thno.90370 · Cited by 52 · see citing works
“Extractive plasma membranes inherited the surface structure and protein profile of the original cells, and excelled at interacting with complicated biological environments to avoid unexpected immune response [43].”
Liposomes-enabled cancer chemoimmunotherapy
Zhang, L., Shi, J., Zhu, M., Huang, Y., Lu, Q., Sun, P., Chen, H., Lai, X. P., & Fang, C. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122801 · Cited by 52 · see citing works
Self-citation
Intelligent Biomaterialomics: Molecular Design, Manufacturing, and Biomedical Applications
Yi, Y., An, H., & Wang, H. (2023) · Advanced Materials · doi:10.1002/adma.202305099 · Cited by 52 · see citing works
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer
Zhang, W., Fan, Y., Zhang, J., Shi, D., Yuan, J., Ashrafizadeh, M., Li, W., Hu, M., El‐Aty, A. M. A., Hacımüftüoğlu, A., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101005 · Cited by 51 · see citing works
Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity
Li, Y., Guo, Y., Zhang, K., Zhu, R., Chen, X. S., Zhang, Z., & Yang, W. (2023) · Advanced Science · doi:10.1002/advs.202306580 · Cited by 51 · see citing works
Swarm Autonomy: From Agent Functionalization to Machine Intelligence
Wang, Y., Chen, H., Xie, L., Liu, J., Zhang, L., & Yu, J. (2024) · Advanced Materials · doi:10.1002/adma.202312956 · Cited by 51 · see citing works
Self-citation
Nanomedicine for T‐Cell Mediated Immunotherapy
Li, F., Ouyang, J., Chen, Z., Zhou, Z., Essola, J. M., Ali, B., Wu, X., Zhu, M., Guo, W., & Liang, X. (2023) · Advanced Materials · doi:10.1002/adma.202301770 · Cited by 50 · see citing works
Tumor Microenvironment-Activated In Situ Synthesis of Peroxynitrite for Enhanced Chemodynamic Therapy
Li, B., Wu, C., Li, Z., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c10012 · Cited by 49 · see citing works
Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery
Huang, P., Deng, H., Wang, C., Zhou, Y., & Chen, X. S. (2023) · Advanced Materials · doi:10.1002/adma.202307822 · Cited by 49 · see citing works
From bench to bedside: Platelet biomimetic nanoparticles as a promising carriers for personalized drug delivery
Safdar, A., Wang, P., Muhaymin, A., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.013 · Cited by 48 · see citing works
Iron oxide nanoparticles in magnetic drug targeting and ferroptosis-based cancer therapy
Shubhra, Q. T. H. (2023) · Medical Review · doi:10.1515/mr-2023-0029 · Cited by 47 · see citing works
“However, similar to other NP types, it is crucial to coat the bare surface of IO NPs (for example, with polymers or cell membranes) to prevent opsonization and aggregation, and evade macrophage uptake, so that they can reach the tumor site (Figure 1A) [2].”
Background
The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications
Mao, Z., Wang, B., Zhang, T., & Cui, B. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06265-2 · Cited by 48 · see citing works
Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation
Ma, Y., Yi, J., Ruan, J., Ma, J., Yang, Q., Zhang, K., Zhang, M., Zeng, G., Jin, L., Huang, X., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400514 · Cited by 48 · see citing works
Engineered platelets as targeted protein degraders and application to breast cancer models
Chen, Y., Pal, S., Li, W., Liu, F., Yuan, S., & Hu, Q. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02494-8 · Cited by 47 · see citing works
Synthetic Biology‐Based Engineering Cells for Drug Delivery
Yi, W., Hu, S., Qian, X., Yan, W., & Li, Y. (2025) · Exploration · doi:10.1002/exp.20240095 · Cited by 47 · see citing works
“Due to the excellent biocompatibility of cell membranes, biomimetic nanomedicines made with cell membrane-encapsulated drug-carrying nanoparticles can effectively avoid clearance by the reticuloendothelial system, thereby extending their circulation time in the bloodstream [258].”
Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: A review on recent advances and future challenges
Jiang, Y., Yan, C., Li, M., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135072 · Cited by 46 · see citing works
Overcoming cancer therapy resistance: From drug innovation to therapeutics
Wei, J., Lu, M., Wei, T., Fleishman, J. S., Yu, H. J., Chen, X.-L., Kong, X.-T., Sun, S., Li, N., Yang, Y., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101229 · Cited by 50 · see citing works
Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives
Chu, Z., Wang, W., Zheng, W., Fu, W., Wang, Y., Wang, H., & Qian, H. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00636d · Cited by 45 · see citing works
Biological self-protection inspired engineering of nanomaterials to construct a robust bio-nano system for environmental applications
Xu, N., Zhang, X., Guo, P.-C., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp2179 · Cited by 45 · see citing works
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Authors: Fang, R. H., Gao, W., & Zhang, L.
Affiliations: University of California San Diego (US)
Corresponding author: Zhang, Liangfang
ORCID: Fang, Ronnie H.
Gao, Weiwei
Zhang, Liangfang
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2022-10-28
Volume: 20
Issue: 1
Pages: 33-48
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/s41571-022-00699-x
OpenAlex: W4307475977
Semantic Scholar: aad18fe7d6405872bceb0dd4451cf81880d894d6
Cited by: 980
References: 162
Citations by year: 2026: 249 · 2025: 320 · 2024: 281 · 2023: 129 · 2022: 1
FWCI: 12.57
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA200574)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: cell membrane-coated nanoparticles, anticancer drug delivery, tumor targeting, biomimetic nanocarriers, immune evasion, phototherapy, cancer immunotherapy, nanoparticle biocompatibility
MeSH terms: Cell Membrane, Pharmaceutical Preparations, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles

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