A multicriteria ranking of organotin (IV) compounds with fungicidal properties
Abstract
Abstract The application of multicriteria decision‐making methods to the results of in vitro antifungal properties of organotin compounds of the type PhxSnXz (x = 2 or 3; X = O2CC6H4OH, O2CC6H4OCOCH3, Cl or O2CCH3; z = 1 or 2) and of free 2‐hydroxybenzoic and 2‐acetoxybenzoic acids against Aspergillus niger, Aspergillus flavus, Candida albicans, Penicillium citrinum, Trichophyton rubrum and Trichophyton violaceum have been described. Ranking information necessary to select one toxicant in preference to others and to assess the properties influencing the preference has been obtained. Patterns in the multivariate analyses suggest that cationic and anionic moieties of the toxicant play some roles in their fungicidal activities. The triphenyltin compounds were generally more active than their diphenyltin analogues, but the acetoxybenzoates were more active than the corresponding hydroxybenzoates, acetates or chlorides. Thus, triphenyltin acetoxybenzoate is up to 7.5 times as active as the corresponding acetate, which is commercially marketed as a fungicide. The results of the analyses have been discussed in the light of the mechanism of antifungal activity of organotin compounds and the potential of multivariate data analysis techniques to facilitate the screening and ranking of antifungal agents. Copyright © 2003 John Wiley & Sons, Ltd.
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Chemometrics has been applied to a wide variety of data matrices including water, fungicidal, pharmaceutical, food science, fruits and vegetables processing, Parkinson's disease, plant composition and polymer analysis studies.
“Chemometrics has been applied to a wide variety of data matrices including those collected for water [58], fungicidal [62], pharmaceutical [63], food science [64], fruits and vegetables processing [65], Parkinson’s disease [66], plant composition [67] and polymer analysis [68] studies.”
From Factors Affecting Microalgae Production for Biofuels and the Potentials of Chemometric Methods in Assessing and Optimizing Productivity (2019) · cites this paper as [62]
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- Authors
- Ayoko, G. A., Bonire, J. J., Abdulkadir, S. S., Olurinola, P. F., Ehinmidu, J. O., Kokot, S., & Yiasel, S.
- Affiliations
- Queensland University of Technology (AU)
- Ahmadu Bello University (NG)
- Corresponding author
- Ayoko, Godwin A.
- ORCID
- Ayoko, Godwin A.
- Venue
- Applied Organometallic Chemistry
- Publisher
- Wiley
- Published
- 2003-08-26
- Volume
- 17
- Issue
- 10
- Pages
- 749-758
- ISSN
- 0268-2605 (ISSN-L)
- 1099-0739
- OpenAlex
- W2077852149
- Cited by
- 43
- References
- 49
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 2
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Organometallic Chemistry (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Organometallic Compounds Synthesis and Characterization
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- organotin compounds, fungicidal activity, antifungal agents, multi-criteria decision making, triphenyltin, diphenyltin, 2-hydroxybenzoic acid, Aspergillus niger, Candida albicans, Trichophyton rubrum, Trichophyton violaceum, structure-activity relationship, antifungal mechanism, fungicide screening
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