Cited by 43Organometallic Compounds Synthesis and CharacterizationMarine Biology and Environmental ChemistryFungal Plant Pathogen Control

A multicriteria ranking of organotin (IV) compounds with fungicidal properties

Ayoko, Godwin A., Bonire, Josiah J., Abdulkadir, Shettima S., Olurinola, Philip F., Ehinmidu, Joseph O., Kokot, Serge, Yiasel, Stephen·2003·Applied Organometallic Chemistry

Abstract

Abstract The application of multicriteria decision‐making methods to the results of in vitro antifungal properties of organotin compounds of the type PhxSnXz (x = 2 or 3; X = O2CC6H4OH, O2CC6H4OCOCH3, Cl or O2CCH3; z = 1 or 2) and of free 2‐hydroxybenzoic and 2‐acetoxybenzoic acids against Aspergillus niger, Aspergillus flavus, Candida albicans, Penicillium citrinum, Trichophyton rubrum and Trichophyton violaceum have been described. Ranking information necessary to select one toxicant in preference to others and to assess the properties influencing the preference has been obtained. Patterns in the multivariate analyses suggest that cationic and anionic moieties of the toxicant play some roles in their fungicidal activities. The triphenyltin compounds were generally more active than their diphenyltin analogues, but the acetoxybenzoates were more active than the corresponding hydroxybenzoates, acetates or chlorides. Thus, triphenyltin acetoxybenzoate is up to 7.5 times as active as the corresponding acetate, which is commercially marketed as a fungicide. The results of the analyses have been discussed in the light of the mechanism of antifungal activity of organotin compounds and the potential of multivariate data analysis techniques to facilitate the screening and ranking of antifungal agents. Copyright © 2003 John Wiley & Sons, Ltd.

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Crossref · 10.1002/aoc.520

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  • Chemometrics has been applied to a wide variety of data matrices including water, fungicidal, pharmaceutical, food science, fruits and vegetables processing, Parkinson's disease, plant composition and polymer analysis studies.

    “Chemometrics has been applied to a wide variety of data matrices including those collected for water [58], fungicidal [62], pharmaceutical [63], food science [64], fruits and vegetables processing [65], Parkinson’s disease [66], plant composition [67] and polymer analysis [68] studies.”

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Authors
Ayoko, G. A., Bonire, J. J., Abdulkadir, S. S., Olurinola, P. F., Ehinmidu, J. O., Kokot, S., & Yiasel, S.
Affiliations
  • Queensland University of Technology (AU)
  • Ahmadu Bello University (NG)
Corresponding author
Ayoko, Godwin A.
Venue
Applied Organometallic Chemistry
Publisher
Wiley
Published
2003-08-26
Volume
17
Issue
10
Pages
749-758
ISSN
  • 0268-2605 (ISSN-L)
  • 1099-0739
OpenAlex
W2077852149
Cited by
43
References
49
Citations by year
2024: 1 · 2023: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 2
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Locations
Applied Organometallic Chemistry (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Organometallic Compounds Synthesis and Characterization
  • Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
organotin compounds, fungicidal activity, antifungal agents, multi-criteria decision making, triphenyltin, diphenyltin, 2-hydroxybenzoic acid, Aspergillus niger, Candida albicans, Trichophyton rubrum, Trichophyton violaceum, structure-activity relationship, antifungal mechanism, fungicide screening

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