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Cell differentiation in the retina of the mouse
Abstract
Cell differentiation in the retina of the mouse during the postnatal period was studied by autoradiography. Animals were injected with 3 H‐thymidine at ages extending from the day of birth through postnatal day 11. Six weeks later the distribution of labeled nuclei in the cells of the mature neural retina was analyzed to determine when these cells completed their final mitosis prior to differentiating. Central and peripheral zones were analyzed separately. Cell division ceases by 5–6 days in the center of the retina and by 11 days in the periphery. Among cells produced postnatally, 73% differentiate as rods, 20% as bipolar cells, 6% as Müller cells, and 1% as amacrine and ganglion cells. At all stages of embryogenesis, the differentiation of at least three and as many as six distinct types of specialized cells is initiated simultaneously within the ventricular cell population.
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Cited by
The Major Cell Populations of the Mouse Retina
Jeon, C.-J., Strettoi, E., & Masland, R. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08936.1998 · Cited by 1,429
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina
Swaroop, A., Kim, D., & Forrest, D. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2880 · Cited by 560
Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development
Erkman, L., McEvilly, R. J., Luo, L., Ryan, A. K., Hooshmand, F., O'Connell, S. M., Keithley, E. M., Rapaport, D. H., Ryan, A. F., & Rosenfeld, M. G. (1996) · Nature · doi:10.1038/381603a0 · Cited by 517
Tan, E., Ding, X.-Q., Saadi, A., Agarwal, N., Naash, M. I., & Al-Ubaidi, M. R. (2004) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-1114 · Cited by 345
A locus control region adjacent to the human red and green visual pigment genes
Wang, Y., Macke, J. P., Merbs, S. L., Zack, D. J., Klaunberg, B., Bennett, J., Gearhart, J., & Nathans, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90181-c · Cited by 325
Metadata
- Authors
- Young, R. W.
- Venue
- The Anatomical Record
- Publisher
- Wiley
- Published
- 1985-06
- Volume
- 212
- Issue
- 2
- Pages
- 199-205
- ISSN
- 0003-276X (ISSN-L)
- 1097-0185
- OpenAlex
- W2059679976
- Cited by
- 1,071
- References
- 0
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Young, R. W. (1985). Cell differentiation in the retina of the mouse. The Anatomical Record. https://doi.org/10.1002/ar.1092120215
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