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Cited by 382

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Serum interferon levels in patients with systemic lupus erythematosus

Ytterberg, Steven R., Schnitzer, Thomas J.·1982·Arthritis & Rheumatism
DOI 10.1002/art.1780250407
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Abstract

Levels of interferon (IFN) were measured in 81 serum samples from 23 patients with systemic lupus erythematosus (SLE) by a plaque‐reduction method and correlated retrospectively with clinical records of disease activity, anti‐DNA binding, and serum complement measurements. IFN titers were found to correlate with both clinical disease activity and anti‐DNA binding, but no relation was found to serum complement. Most (76.6%, 31 of 41) serum samples obtained during periods of active disease contained measureable amounts of IFN, but only 9.1% (2 of 22) of results of tests on samples obtained during periods of disease quiescence were positive (P < 0.005). Of samples with clearly elevated anti‐DNA binding (> 40%), 69.7% (23 of 33) had positive results for IFN, but 57.1% (8 of 14) had negative results when the anti‐DNA binding was normal (< 20%) (P < 0.005). Measurement of serum IFN titers in patients with SLE, therefore, provides another serologic marker of disease activity. Contrary to the findings of previous studies, the IFN found in the present study was characterized as IFN‐α, or Type I IFN, on the basis of acid stability and neutralization by antibody to IFN‐α. Of interest are the questions raised about the origin of IFN in the sera of patients with SLE and what role IFN might have in the pathogenesis of the autoimmune disease in view of the many documented immunomodulating effects of IFN.

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Metadata

Authors
Ytterberg, S. R., & Schnitzer, T. J.
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
1982-04
Volume
25
Issue
4
Pages
401-406
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.1780250407
OpenAlex
W2162082073
Cited by
382
References
12
FWCI
9.78
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Serum interferon levels in patients with systemic lupus erythematosus. https://app.cochat.ai/papers/10.1002/art.1780250407
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Ytterberg, S. R., & Schnitzer, T. J. (1982). Serum interferon levels in patients with systemic lupus erythematosus. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780250407

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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