The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F1 but Not in BALB/c Mice
Open accessAbstract
Recent studies indicate that IFN-α is involved in pathogenesis of systemic lupus erythematosus. However, direct proof that IFN-α is not only necessary, but also sufficient to induce lupus pathogenicity is lacking. In this study, we show that in vivo adenovector-mediated delivery of murine IFN-α results in preautoimmune (New Zealand Black (NZB) × New Zealand White (NZW))F1, but not in normal, mice, in a rapid and severe disease with all characteristics of systemic lupus erythematosus. Anti-dsDNA Abs appeared as soon as day 10 after initiation of IFN-α treatment. Proteinuria and death caused by glomerulonephritis occurred in all treated mice within, respectively, ∼9 and ∼18 wk, at a time when all untreated (NZB × NZW)F1 did not show any sign of disease. IFN-α in vivo induced an overexpression of B lymphocyte stimulator in circulation at similar levels in both the preautoimmune and the normal mouse strains. All effects elicited by IFN-α were dose dependent. (NZB × NZW)F1 infused with purified murine IFN-α also showed acceleration of lupus. Thus, prolonged expression of IFN-α in vivo induces early lethal lupus in susceptible animals.
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Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
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Self-citationCellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.
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Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations
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Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus
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Self-citationTACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
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Cited by
Knight, J. S., Subramanian, V., O'Dell, A. A., Yalavarthi, S., Zhao, W., Smith, C. K., Hodgin, J. B., Thompson, P. R., & Kaplan, M. J. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-205365 · Cited by 443
Taming lupus-a new understanding of pathogenesis is leading to clinical advances
Liu, Z., & Davidson, A. (2012) · Nature Medicine · doi:10.1038/nm.2752 · Cited by 433
Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9
Tursi, S. A., Lee, E. Y., Medeiros, N. J., Lee, M. H., Nicastro, L. K., Buttaro, B., Gallucci, S., Wilson, R. P., Wong, G. C. L., & Tükel, Ç. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006315 · Cited by 115
Metadata
- Authors
- Mathian, A., Weinberg, A., Gallegos, M., Banchereau, J., & Koutouzov, S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-01
- Volume
- 174
- Issue
- 5
- Pages
- 2499-2506
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1547552531
- Cited by
- 270
- References
- 51
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F1 but Not in BALB/c Mice. https://app.cochat.ai/papers/10.4049/jimmunol.174.5.2499
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- Mathian, A., Weinberg, A., Gallegos, M., Banchereau, J., & Koutouzov, S. (2005). IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F1 but Not in BALB/c Mice. The Journal of Immunology. https://doi.org/10.4049/jimmunol.174.5.2499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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