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Cited by 733

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.

Open access
Trinchieri, G, Santoli, D·1978·The Journal of experimental medicine
DOI 10.1084/jem.147.5.1314
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Abstract

Interferon, induced in lymphocytes either with viruses or cell lines, increases severalfold the natural cytotoxicity of human lymphocytes on target cell lines. Cell separation experiments support the hypothesis that interferon enhances the activity of natural killer cells rather than generating a new population of effector cells. In mixed culture of lymphocytes and cell lines in which endogenous interferon is produced, interferon mediates an enhancement of cytotoxicity that represents up to 70-90% of the observed cytotoxicity. The effect of interferon on target cells is antagonistic to the effect on the lymphocytes: the susceptibility to cell-mediated lysis of various cells upon pretreatment with interferon is decreased and in some cases almost completely suppressed. Interferon renders target cells resistant to natural killer cells acting by an intracellular mechanism which requires RNA and protein synthesis. While normal fibroblasts are protected, virus-infected cells and most tumor cells usually are not protected by interferon. Interferon by stimulating very efficient nonspecific cytotoxic cells and by protecting at the same time normal cells from lysis, might render the natural killer cell system an inducible selective defense mechanism against tumor and virus-infected cells.

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Metadata

Authors
Trinchieri, G., & Santoli, D.
Venue
The Journal of experimental medicine
Publisher
Rockefeller University Press
Published
1978-05-01
Volume
147
Issue
5
Pages
1314-1333
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.147.5.1314
OpenAlex
W2143143209
Cited by
733
References
23
FWCI
30.34
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. https://app.cochat.ai/papers/10.1084/jem.147.5.1314
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Trinchieri, G., & Santoli, D. (1978). Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. The Journal of experimental medicine. https://doi.org/10.1084/jem.147.5.1314

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.