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Cited by 145Bone Metabolism and DiseasesRheumatoid Arthritis Research and TherapiesBone health and osteoporosis research

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis.

Shimizu, Shinichi, Shiozawa, Shunichi, Shiozawa, Kazuko, Imura, Shigeaki, Fujita, Takuo·1985·Arthritis & Rheumatism
DOI 10.1002/art.1780280105
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Abstract

The pathogenesis of periarticular osteopenia in rheumatoid arthritis (RA) was investigated by histomorphometry on juxtaarticular bone removed during joint surgery. Twenty areas from 12 RA patients were compared with 14 areas from 6 osteoarthritis (OA) patients. There was no difference between the 2 groups in the percent of total bone volume. However, increased bone formation was suggested by an increase in the percent of active osteoid surface in RA compared with that in OA. Bone resorption was also increased in RA, as evidenced by increases versus OA in percent total resorptive surface, percent active resorptive surface, and number of osteoclasts. These results demonstrate increased turnover of bone in RA, especially in the resorptive phase of the periarticular trabecular bone. It is proposed that soluble factor(s) synthesized in the contiguous rheumatoid synovium may be transferred to the periarticular bone space, stimulating osteoclasts to resorb bone.

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Crossref · 10.1002/art.1780280105

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  • Rheumatoid arthritis is characterized by multiple forms of osteoclast-mediated bone loss, including focal bone erosions at the bone-pannus junction, subchondral bone loss adjacent to inflamed joints, and generalized systemic bone loss.

    “multiple forms of osteoclast-mediated bone loss that are characteristic of the disease, including focal bone erosions at the bone-pannus junction of inflamed joints, subchondral (periarticular) bone loss adjacent to inflamed joints, and generalized systemic bone loss (223-227).”

    From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [226]

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Authors
Shimizu, S., Shiozawa, S., Shiozawa, K., Imura, S., & Fujita, T.
Affiliations
  • Kobe University (JP)
  • Kakogawa City Hospital Organization (JP)
Corresponding author
Shiozawa, Shunichi
ORCID
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
1985-01
Volume
28
Issue
1
Pages
25-31
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.1780280105
OpenAlex
W2133783680
Cited by
145
References
33
Citations by year
2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 5
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7636 d)
Locations
  • Arthritis & Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
periarticular osteoporosis, rheumatoid arthritis, osteoarthritis, bone turnover, bone resorption, osteoclasts, trabecular bone
MeSH terms
Adrenal Cortex Hormones, Adult, Aged, Anthropometry, Arthritis, Rheumatoid, Bone and Bones, Bone Resorption, Female, Humans, Knee Joint, Male, Middle Aged, Osteoarthritis, Osteoporosis, Periarthritis

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