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Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis
Open accessAbstract
Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.
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Citations
Cited by
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Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864
Epigenetics and gene expression
Gibney, E. R., & Nolan, C. M. (2010) · Heredity · doi:10.1038/hdy.2010.54 · Cited by 1,109
Toll-like receptors in systemic autoimmune disease
Marshak-Rothstein, A. (2006) · Nature Reviews Immunology · doi:10.1038/nri1957 · Cited by 1,116
Javierre, B. M., Fernandez, A. F., Richter, J., Al-Shahrour, F., Martin-Subero, J. I., Rodriguez-Ubreva, J., Berdasco, M., Fraga, M. F., O'Hanlon, T. P., Rider, L. G., et al. (2010) · Genome Research · doi:10.1101/gr.100289.109 · Cited by 668
Metadata
- Authors
- Richardson, B., Scheinbart, L., Strahler, J., Gross, L., Hanash, S., & Johnson, M.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1990-11
- Volume
- 33
- Issue
- 11
- Pages
- 1665-1673
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1994009027
- Cited by
- 562
- References
- 0
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Richardson, B., Scheinbart, L., Strahler, J., Gross, L., Hanash, S., & Johnson, M. (1990). Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780331109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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