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Frequency of lupus flare in pregnancy: The hopkins lupus pregnancy center experience
Abstract
To determine whether pregnancy is associated with an increased rate of flare in patients with systemic lupus erythematosus (SLE), we prospectively studied 40 pregnancies in 37 women with SLE. The women were evaluated on a monthly basis in the Hopkins Lupus Pregnancy Center. Flare was designated using a previously developed quantitative definition, i.e., a change of >1.0 in the physician's global assessment (scale of 0–3) since the preceding visit or during the last 93 days. Flare occurred in 24 (60%) of the pregnancies. Flares presented most commonly as constitutional symptoms, renal involvement, or involvement of skin or joints. Comparison of the rates of flare in the same patients after delivery and in nonpregnant SLE patients showed a significant increase in the rate of flare during pregnancy (P <0.001 and P <0.0001, respectively). We conclude that flare of lupus during pregnancy is common and occurs significantly more frequently than does flare in nonpregnant SLE patients or in the same patients after pregnancy.
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Cited by
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Petri, M., Elkhalifa, M., Li, J., Magder, L. S., & Goldman, D. W. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41121 · Cited by 143
Self-citationImmunomodulators in SLE: Clinical evidence and immunologic actions
Durcan, L., & Petri, M. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.06.010 · Cited by 92
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Metadata
- Authors
- Petri, M., Howard, D., & Repke, J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 34
- Issue
- 12
- Pages
- 1538-1545
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2048642898
- Cited by
- 390
- References
- 0
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Petri, M., Howard, D., & Repke, J. (1991). Frequency of lupus flare in pregnancy: The hopkins lupus pregnancy center experience. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780341210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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