Cited by 192Systemic Lupus Erythematosus ResearchAdrenal Hormones and DisordersSystemic Sclerosis and Related Diseases

Dehydroepiandrosterone in systemic lupus erythematosus

Van Vollenhoven, Ronald F., Engleman, Edgar G., Mcguire, James L.·1995·Arthritis & Rheumatism

Abstract

OBJECTIVE: To determine if dehydroepiandrosterone (DHEA) is beneficial in the treatment of systemic lupus erythematosus (SLE). METHODS: In a double-blind, placebo-controlled, randomized trial, 28 female patients with mild to moderate SLE were given DHEA 200 mg/day or placebo for 3 months. Outcomes included the SLE Disease Activity Index (SLEDAI) score, patient's and physician's overall assessments of disease activity, and concurrent corticosteroid dosages (which were adjusted as clinically indicated). RESULTS: In the patients who were receiving DHEA, the SLEDAI score, patient's and physician's overall assessment of disease activity, and concurrent prednisone dosage decreased, while in the patients taking placebo, small increases were seen. The difference in patient's assessment between the groups was statistically significant (P = 0.022, adjusted). Lupus flares occurred more frequently in the placebo group (P = 0.053). Mild acne was a frequent side effect of DHEA. CONCLUSION: DHEA may be useful as a therapeutic agent for the treatment of mild to moderate SLE. Further studies of DHEA in the treatment of SLE are warranted.

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Crossref · 10.1002/art.1780381216

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Authors
Van Vollenhoven, R. F., Engleman, E. G., & Mcguire, J. L.
Affiliations
Stanford Medicine (US)
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
1995-12
Volume
38
Issue
12
Pages
1826-1831
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
OpenAlex
W2070207717
Cited by
192
References
36
Citations by year
2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 5
FWCI
5.90
Type
journal article
Language
en
Open access
closed
Locations
  • Arthritis & Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Keywords
dehydroepiandrosterone, systemic lupus erythematosus, lupus flares, corticosteroid tapering, prednisone, SLEDAI, disease activity, acne, steroid-sparing therapy
MeSH terms
Adult, Dehydroepiandrosterone, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Lupus Erythematosus, Systemic, Prednisone, Severity of Illness Index, Chi-Square Distribution

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