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Generalized osteoarthritis associated with increased insulin‐like growth factor types i and ii and transforming growth factor β in cortical bone from the iliac crest. possible mechanism of increased bone density and protection against osteoporosis
Abstract
Objective. To investigate whether growth factors stored in bone might explain the increased bone density and resistance to osteoporosis in generalized osteoarthritis. Methods. Levels of insulin‐like growth factor (IGF) types I and II and transforming growth factor β (TGFβ) were measured in extracts of cortical bone from the iliac crest obtained at necropsy from subjects with or without osteoarthritis of the hands. Results. Concentrations of IGF‐I, IGF‐II, and TGFβ were significantly higher in extracts of bone powder from subjects in the osteoarthritis group than in extracts from subjects in the control group. Conclusion. The results suggest that the increased bone density and resistance to osteoporosis in patients with osteoarthritis may be associated with increased skeletal concentrations of IGF‐I, IGF‐II, and TGFβ and may reflect a generally increased biosynthetic activity of osteoblasts in these patients.
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Citations
Cited by
Growth factors for bone growth and repair: IGF, TGFβ and BMP
Linkhart, T. A., Mohan, S., & Baylink, D. J. (1996) · Bone · doi:10.1016/s8756-3282(96)00138-x · Cited by 440
Self-citationBone–cartilage crosstalk: a conversation for understanding osteoarthritis
Findlay, D. M., & Kuliwaba, J. S. (2016) · Bone Research · doi:10.1038/boneres.2016.28 · Cited by 283
Osteoarthritis and osteoporosis: Clinical and research evidence of inverse relationship
Dequeker, J., Aerssens, J., & Luyten, F. P. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03327364 · Cited by 269
Self-citationHilal, G., Martel-Pelletier, J., Pelletier, J.-P., Ranger, P., & Lajeunesse, D. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199805)41:5<891::aid-art17>3.0.co;2-x · Cited by 211
Fazzalari, N. L., Kuliwaba, J. S., Atkins, G. J., Forwood, M. R., & Findlay, D. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1015 · Cited by 129
Metadata
- Authors
- Dequeker, J., Mohan, S., Finkelman, R. D., Aerssens, J., & Baylink, D. J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1993-12
- Volume
- 36
- Issue
- 12
- Pages
- 1702-1708
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2070335386
- Cited by
- 190
- References
- 0
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dequeker, J., Mohan, S., Finkelman, R. D., Aerssens, J., & Baylink, D. J. (1993). Generalized osteoarthritis associated with increased insulin‐like growth factor types i and ii and transforming growth factor β in cortical bone from the iliac crest. possible mechanism of increased bone density and protection against osteoporosis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780361209
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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