The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Comparison of Amitriptyline, Cyclobenzaprine, and Placebo in the Treatment of Fibromyalgia
Abstract
Objective. To compare the relative efficacy and tolerability of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia, and to identify predictors of response to amitriptyline and cyclobenzaprine. Methods, Two hundred eight patients who fulfilled the American College of Rheumatology criteria for the classification of fibromyalgia were entered into a 6‐month prospective, double‐blind, multicenter trial and were randomized to 1 of 3 treatment groups: amitriptyline, cyclobenzaprine, or placebo. Results. After 1 month, 21%, 12%, and 0% of the amitriptyline, cyclobenzaprine, and placebo patients, respectively, had significant clinical improvement (amitriptyline versus placebo P = 0.002, cyclobenzaprine versus placebo P = 0.02, amitriptyline versus cyclobenzaprine P not significant). These percentages increased to 36%, 33%, and 19%, respectively, at the 6‐month assessment (P not significant). The nature and frequency of side effects reported by patients treated with amitriptyline and those reported by patients treated with cyclobenzaprine were similar. A normal Minnesota Multiphasic Personality Inventory (MMPI) profile at baseline was predictive of clinical improvement at the 1‐month evaluation (odds ratio 3.3, 95% confidence interval 1.2—9.0). However, neither the MMPI profile nor any of the demographic, clinical, or functional parameters evaluated at baseline predicted long‐term response. Conclusion. Our data confirm the short‐term efficacy of amitriptyline and cyclobenzaprine in a small percentage of patients with fibromyalgia. Long‐term efficacy could not be demonstrated because of a higher‐than‐expected placebo response. Predictors of response to these drugs could not be determined.
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Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
Self-citationThe McGill Pain Questionnaire: Major properties and scoring methods
Melzack, R. (1975) · Pain · doi:10.1016/0304-3959(75)90044-5 · Cited by 6,845
The Sickness Impact Profile: Development and Final Revision of a Health Status Measure
Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981) · Medical Care · doi:10.1097/00005650-198108000-00001 · Cited by 4,619
Measurement of patient outcome in arthritis
Fries, J. F., Spitz, P., Kraines, R. G., & Holman, H. R. (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230202 · Cited by 4,382
The Minnesota Multiphasic Personality Inventory
BRITTON, P. G., & SAVAGE, R. D. (1966) · Readings in Clinical Psychology · doi:10.1016/b978-1-4832-0087-3.50014-0 · Cited by 1,434
Measuring health status in arthritis
Meenan, R. F., Gertman, P. M., & Mason, J. H. (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230203 · Cited by 1,176
Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls
Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L. (1981) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(81)90096-2 · Cited by 910
Moldofsky, H., Scarisbrick, P., England, R., & Smythe, H. (1975) · Psychosomatic Medicine · doi:10.1097/00006842-197507000-00008 · Cited by 854
Induction of Neurasthenic Musculoskeletal Pain Syndrome by Selective Sleep Stage Deprivation
Moldofsky, H., & Scarisbrick, P. (1976) · Psychosomatic Medicine · doi:10.1097/00006842-197601000-00006 · Cited by 564
A Controlled Trial of Corticosteroid Injections into Facet Joints for Chronic Low Back Pain
Carette, S., Marcoux, S., Truchon, R., Grondin, C., Gagnon, J., Allard, Y., & Latulippe, M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110033251405 · Cited by 542
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Management of fibromyalgia syndrome
Goldenberg, D. L. (2004) · JAMA · doi:10.1001/jama.292.19.2388 · Cited by 850
EULAR evidence-based recommendations for the management of fibromyalgia syndrome
Carville, S. F., Arendt-Nielsen, S., Bliddal, H., Blotman, F., Branco, J. C., Buskila, D., Da Silva, J. A. P., Danneskiold-Samsøe, B., Dincer, F., Henriksson, C., et al. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.071522 · Cited by 752
Arnold, L. M., Lu, Y., Crofford, L. J., Wohlreich, M., Detke, M. J., Iyengar, S., & Goldstein, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20485 · Cited by 624
Antidepressant Treatment of Fibromyalgia: A Meta-Analysis and Review
Arnold, L. M., Keck, P. E., & Welge, J. A. (2000) · Psychosomatics · doi:10.1176/appi.psy.41.2.104 · Cited by 448
Treatment of fibromyalgia with antidepressants: A meta-analysis
O’Malley, P. G., Balden, E., Tomkins, G., Santoro, J., Kroenke, K., & Jackson, J. L. (2000) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2000.06279.x · Cited by 340
Metadata
- Authors
- Carette, S., Bell, M. J., Reynolds, W. J., Haraoui, B., Mccain, G. A., Bykerk, V. P., Edworthy, S. M., Baron, M., Koehler, B. E., Fam, A. G., Bellamy, N., & Guimont, C.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 37
- Issue
- 1
- Pages
- 32-40
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2013721829
- Cited by
- 340
- References
- 35
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carette, S., Bell, M. J., Reynolds, W. J., Haraoui, B., Mccain, G. A., Bykerk, V. P., Edworthy, S. M., Baron, M., Koehler, B. E., Fam, A. G., Bellamy, N., & Guimont, C. (1994). Comparison of Amitriptyline, Cyclobenzaprine, and Placebo in the Treatment of Fibromyalgia. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780370106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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