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Cited by 910Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsMyofascial pain diagnosis and treatment

Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls

Yunus, Muhammad, Masi, Alfonse T., Calabro, John J., Miller, Kenneth A., Feigenbaum, Seth L.·1981·Seminars in Arthritis and Rheumatism
DOI 10.1016/0049-0172(81)90096-2
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Abstract

Detailed clinical study of 50 patients with primary fibromyalgia and 50 normal matched controls has shown a characteristic syndrome. Primary fibromyalgia patients are usually females, aged 25-40 yr, who complain of diffuse musculoskeletal aches, pains or stiffness associated with tiredness, anxiety, poor sleep, headaches, irritable bowel syndrome, subjective swelling in the articular and periarticular areas and numbness. Physical examination is characterized by presence of multiple tender points at specific sites and absence of joint swelling. Symptoms are influenced by weather and activities, as well as by time of day(worse in the morning and the evening). In contrast, symptoms of psychogenic rheumatism patients have little fluctuation, if any, and are modulated by emotional rather than physical factors. In psychogenic rheumatism, there is diffuse tenderness rather than tender points at specific sites. Laboratory tests and roentgenologic findings in primary fibromyalgia are normal or negative. Primary fibromyalgia should be suspected by the presence of its own characteristic features, and not diagnosed just by the absence of other recognizable conditions. This study has also shown that primary fibromyalgia is a poorly recognized condition. Patients were usually seen by many physicians who failed to provide a definite diagnosis despite frequent unnecessary investigations. A guideline for diagnosis of primary fibromyalgia, based upon our observations, is suggested. Management…

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Crossref · 10.1016/0049-0172(81)90096-2

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75 of 75 references verified0 citation errors · 0 not checkable

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Authors
Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • Northwestern Medicine (US)
Corresponding author
Masi, Alfonse T.
ORCID
Masi, Alfonse T.
Venue
Seminars in Arthritis and Rheumatism
Publisher
Elsevier BV
Published
1981-08
Volume
11
Issue
1
Pages
151-171
ISSN
0049-0172 (ISSN-L)
DOI
10.1016/0049-0172(81)90096-2
OpenAlex
W2067444992
Cited by
910
References
78
Citations by year
2026: 8 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 14 · 2019: 7 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 14 · 2014: 24 · 2013: 14 · 2012: 29
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Seminars in Arthritis and Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
Keywords
primary fibromyalgia, fibromyalgia, tender points, psychogenic rheumatism, diagnostic criteria, differential diagnosis, musculoskeletal pain, nonsteroidal anti-inflammatory drugs, physiotherapy, sleep
MeSH terms
Adolescent, Adult, Anxiety, Circadian Rhythm, Colonic Diseases, Functional, Diagnosis, Fatigue, Female, Fibromyalgia, Headache, Humans, Joints, Male, Middle Aged, Pain, Referral and Consultation, Sleep Wake Disorders, Time Factors, Weather

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