The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Treatment of glucocorticoid‐resistant or relapsing takayasu arteritis with methotrexate
Abstract
Objective. To identify the role of methotrexate (MTX) in the treatment of persistent or recurrent Takayasu arteritis that is refractory to treatment with glucocorticoids (GC) alone. Methods. An open‐label pilot study of weekly low‐dose MTX + GC treatment was performed. Outcome was evaluated according to clinical characteristics, laboratory abnormalities, findings on routinely performed angiographic studies, and ability to withdraw GC and MTX therapy. Eighteen patients entered the study; 2 dropped out, and 16 were followed up for a mean period of 2.8 years (range 1.3–4.8 years). Results. Weekly administration of MTX (mean stable dose of 17.1 mg) and GC resulted in remissions in 13 of 16 patients (81%). However, 7 patients (44%) had relapses as GC was tapered to or near discontinuation. Retreatment again led to remission, and 3 of 7 patients in this group have successfully stopped GC therapy. Of those patients who achieved remission, 8 (50%) have sustained remissions of 4–34 months (mean 18 months), and 4 of this group have not required GC or MTX therapy for 7–18 months (mean 11.3 months). Three patients experienced disease progression in spite of treatment. Conclusion. About half of all Takayasu arteritis patients have chronic active disease for which GC therapy alone does not provide sustained remissions that allow withdrawal of treatment. Weekly low‐dose MTX is an effective means of inducing remission and minimizing GC therapy and toxicity in most of these patients. Further long‐term studies will be required to assess the durability of remission and the need for maintenance MTX therapy in this subset of Takayasu arteritis patients.
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Cites
Wegener Granulomatosis: An Analysis of 158 Patients
Hoffman, G. S., Kerr, G. S., Leavitt, R. Y., Hallahan, C. W., Lebovics, R. S., Travis, W. D., Rottem, M., & Fauci, A. S. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-6-488 · Cited by 2,857
Self-citationTakayasu arteritis. A study of 32 North American patients.
Hall, S., Barr, W. G., Lie, J. T., Stanson, A. W., Kazmier, F. J., & Hunder, G. G. (1985) · PubMed · Cited by 620
Takayasu Arteritis: A STUDY OF 32 NORTH AMERICAN PATIENTS
HALL, S., BARR, W., LIE, J. T., STANSON, A. W., KAZMIER, F. J., & HUNDER, G. G. (1985) · Medicine · doi:10.1097/00005792-198503000-00002 · Cited by 572
Cronstein, B. N., Eberle, M. A., Gruber, H. E., & Levin, R. I. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.6.2441 · Cited by 332
Treatment of Wegener's granulomatosis with intermittent high-dose intravenous cyclophosphamide
Hoffman, G. S., Leavitt, R. Y., Fleisher, T. A., Minor, J. R., & Fauci, A. S. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90367-m · Cited by 201
Self-citationThe effects of methotrexate on the production and activity of interleukin‐1
Segal, R., Mozes, E., Yaron, M., et al. (1989) · Arthritis & Rheumatism · doi:10.1002/anr.1780320403 · Cited by 133
Immunologic studies of rheumatoid arthritis patients treated with methotrexate
Olsen, N. J., Callahan, L. F., & Pincus, T. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780300501 · Cited by 112
Sperling, R. I., Coblyn, J. S., Larkin, J. K., Benincaso, A. I., Austen, K. F., & Weinblatt, M. E. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330815 · Cited by 67
Hoffman, R. W., Sharp, G. C., Irvin, W. S., Anderson, S. K., Hewett, J. E., & Pandey, J. P. (1991) · Arthritis & Rheumatism · doi:10.1002/art.1780340410 · Cited by 51
Methotrexate inhibits polymorphonuclear leucocyte chemotaxis in psoriasis
WALSDORFER, U., Christophers, E., & SCHRODER, J.-M. (1983) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1983.tb04598.x · Cited by 39
Cited by
Kleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K. M., Gutierrez, J., Lombardi-Hill, D., Kamel, H., Kernan, W. N., Kittner, S. J., Leira, E. C., et al. (2021) · Stroke · doi:10.1161/str.0000000000000375 · Cited by 3,237
Mahr, A. D., Jover, J. A., Spiera, R. F., Hernández‐García, C., Fernández‐Gutiérrez, B., LaValley, M. P., & Merkel, P. A. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22754 · Cited by 622
Hoffman, G. S., Cid, M. C., Hellmann, D. B., Guillevin, L., Stone, J. H., Schousboe, J., Cohen, P., Calabrese, L. H., Dickler, H., Merkel, P. A., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10262 · Cited by 579
Self-citationNakaoka, Y., Isobe, M., Takei, S., Tanaka, Y., Ishii, T., Yokota, S., Nomura, A., Yoshida, S., & Nishimoto, N. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211878 · Cited by 344
Unizony, S., Arias‐Urdaneta, L., Miloslavsky, E., Arvikar, S., Khosroshahi, A., Keroack, B., Stone, J. R., & Stone, J. H. (2012) · Arthritis Care & Research · doi:10.1002/acr.21750 · Cited by 272
Metadata
- Authors
- Hoffman, G. S., Leavitt, R. Y., Kerr, G. S., Rottem, M., Sneller, M. C., & Fauci, A. S.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1994-12
- Volume
- 37
- Issue
- 4
- Pages
- 578-582
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2142991076
- Cited by
- 409
- References
- 10
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
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