The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Shift toward T lymphocytes with a T helper 1 cytokine‐secretion profile in the joints of patients with rheumatoid arthritis
Abstract
Objective. To investigate whether T cells in the inflamed joints of patients with rheumatoid arthritis (RA) preferentially produce the T helper 1 (Th1) cytokines, interferon‐γ (IFNγ) and interleukin‐2 (IL‐2), or the Th2 cytokine, IL‐4, when compared with corresponding peripheral blood—derived T cells. Methods. Synovial fluid mononuclear cells (SFMC) and corresponding peripheral blood mononuclear cells (PBMC) from 10 patients with RA were analyzed, either directly or after in vitro stimulation, for the intracellular presence of Th1 and Th2 cytokines. The amount of secreted cytokine in the cell culture supernatants was measured by enzyme‐linked immunosorbent assay (ELISA). Results. IFNγ‐containing cells were detected in the unstimulated SFMC, but not in the PBMC, of 3 patients with RA. Cells positive for IL‐2 or IL‐4 were not detected in the unstimulated samples. Following stimulation, the mean percentage of cells containing Th1 cytokines was significantly increased in the SFMC compared with the PBMC; no differences were found in the mean percentage of IL‐4—containing cells. A comparable shift toward Th1 cytokines was observed when the amount of secreted cytokine was determined by ELISA. Conclusion. A shift toward T cells with a Th1 cytokine profile was observed in the joints of patients with RA. Since an imbalance between Th1 and Th2 cells is thought to be of pathogenic significance, this finding might have implications for the development of new therapies for RA.
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Lymphokine Production by Human T Cells in Disease States
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Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells
Mosmann, T. R., & Coffman, R. L. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60652-5 · Cited by 1,106
Human TH1 and TH2 subsets: doubt no more
Romagnani, S. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90120-i · Cited by 1,089
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Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.
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How important are t cells in chronic rheumatoid synovitis?
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Cited by
Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554
A novel anti-inflammatory role for simvastatin in inflammatory arthritis.
Leung, B. P., Sattar, N., Crilly, A., Prach, M., McCarey, D. W., Payne, H., Madhok, R., Campbell, C., Gracie, J. A., Liew, F. Y., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1524 · Cited by 434
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma.
McKay, A., Leung, B. P., McInnes, I. B., Thomson, N. C., & Liew, F. Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2903 · Cited by 309
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01744 · Cited by 308
Goebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200007000-00019 · Cited by 189
Metadata
- Authors
- Dolhain, R. J. E. M., van der Heiden, A. N., ter Haar, N. T., Breedveld, F. C., & Miltenburg, A. M. M.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1996-12
- Volume
- 39
- Issue
- 12
- Pages
- 1961-1969
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2032169254
- Cited by
- 295
- References
- 30
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Shift toward T lymphocytes with a T helper 1 cytokine‐secretion profile in the joints of patients with rheumatoid arthritis. https://app.cochat.ai/papers/10.1002/art.1780391204
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- Dolhain, R. J. E. M., van der Heiden, A. N., ter Haar, N. T., Breedveld, F. C., & Miltenburg, A. M. M. (1996). Shift toward T lymphocytes with a T helper 1 cytokine‐secretion profile in the joints of patients with rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780391204
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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