The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
Open accessAbstract
CD4 T helper precursor cells mature along two alternative pathways, Th1 and Th2. Here we show that these pathways are differentially activated by two costimulatory molecules, B7-1 and B7-2. Using anti-B7 antibodies, this developmental step was manipulated both in vitro and in vivo in experimental allergic encephalomyelitis (EAE). Anti-B7-1 reduced the incidence of disease while anti-B7-2 increased disease severity. Neither antibody affected overall T cell induction but rather altered cytokine profile. Administration of anti-B7-1 at immunization resulted in predominant generation of Th2 clones whose transfer both prevented induction of EAE and abrogated established disease. Since co-treatment with anti-IL-4 antibody prevented disease amelioration, costimulatory molecules may directly affect initial cytokine secretion. Thus, interaction of B7-1 and B7-2 with shared counterreceptors CD28 and CTLA-4 results in very different outcomes in clinical disease by influencing commitment of precursors to a Th1 or Th2 lineage.
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Cites
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CTLA-4 can function as a negative regulator of T cell activation
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Self-citationLymphocyte responses and cytokines
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CTLA-4 is a second receptor for the B cell activation antigen B7.
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Cited by
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets
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Self-citationImpaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
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Metadata
- Authors
- Kuchroo, V. K., Prabhu Das, M., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., & Glimcher, L. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 80
- Issue
- 5
- Pages
- 707-718
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2040838085
- Cited by
- 1,641
- References
- 43
- FWCI
- 69.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kuchroo, V. K., Prabhu Das, M., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., & Glimcher, L. H. (1995). B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell. https://doi.org/10.1016/0092-8674(95)90349-6
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