The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept
Abstract
Objective: To investigate the effect of etanercept therapy on radiographic progression in patients with ankylosing spondylitis (AS). Methods: Patients with AS who had previously participated in a 24‐week randomized, double‐blind, placebo‐controlled trial of etanercept therapy were enrolled in a 72‐week open‐label extension. Radiographs of the cervical and lumbar spine from patients who received etanercept (25 mg twice weekly) for up to 96 weeks were compared with radiographs from patients in a large prevalence cohort (Outcome Assessments in Ankylosing Spondylitis International Study [OASIS]) who had not been treated with anti–tumor necrosis factor α (anti‐TNFα) agents. Radiographs obtained at 2 time points up to 96 weeks apart from patients in both study populations were digitized and read by 2 independent readers who were blinded with regard to patient group and sequence. The primary end point was the 96‐week change in the modified Stoke AS Spine Score (mSASSS). Results: A total of 257 patients treated with etanercept were compared with 175 unselected patients from the OASIS study. There was no significant difference in the change in the mSASSS from baseline among patients who received etanercept (mean ± SD 0.91 ± 2.45) versus those from the OASIS group (0.95 ± 3.18). Conclusion: Unlike other inflammatory rheumatic diseases such as rheumatoid arthritis and psoriatic arthritis, structural progression in AS seems to be independent of TNF, despite the fact that TNF is responsible for the signs and symptoms due to inflammation in this disease.
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Dickkopf-1 is a master regulator of joint remodeling
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Etanercept treatment of psoriatic arthritis: Safety, efficacy, and effect on disease progression
Mease, P. J., Kivitz, A. J., Burch, F. X., Siegel, E. L., Cohen, S. B., Ory, P., Salonen, D., Rubenstein, J., Sharp, J. T., & Tsuji, W. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20335 · Cited by 882
Self-citationvan der Heijde, D., Kivitz, A., Schiff, M. H., Sieper, J., Dijkmans, B. A. C., Braun, J., Dougados, M., Reveille, J. D., Wong, R. L., Kupper, H., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21913 · Cited by 872
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van der Heijde, D., Klareskog, L., Rodriguez‐Valverde, V., Codreanu, C., Bolosiu, H., Melo‐Gomes, J., Tornero‐Molina, J., Wajdula, J., Pedersen, R., Fatenejad, S., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21655 · Cited by 535
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Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
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Solovic, I., Sester, M., Gomez-Reino, J. J., Rieder, H. L., Ehlers, S., Milburn, H. J., Kampmann, B., Hellmich, B., Groves, R., Schreiber, S., et al. (2010) · European Respiratory Journal · doi:10.1183/09031936.00028510 · Cited by 527
Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis
Denninger, K. C., Litman, T., Marstrand, T., Moller, K., Svensson, L., Labuda, T., & Andersson, Å. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0531-7 · Cited by 27
Metadata
- Authors
- van der Heijde, D., Landewé, R., Einstein, S., Ory, P., Vosse, D., Ni, L., Lin, S. ‐., Tsuji, W., & Davis, J. C.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2008-04-25
- Volume
- 58
- Issue
- 5
- Pages
- 1324-1331
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2092734189
- Cited by
- 549
- References
- 24
- FWCI
- 29.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- van der Heijde, D., Landewé, R., Einstein, S., Ory, P., Vosse, D., Ni, L., Lin, S. ‐., Tsuji, W., & Davis, J. C. (2008). Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis & Rheumatism. https://doi.org/10.1002/art.23471
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