The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95
Abstract
Objective: Analysis of peripheral B cell subsets in patients with systemic lupus erythematosus (SLE) has provided evidence of specific alterations, such as an expansion of CD27++ plasma cells/blasts and transitional B cells. However, memory B cells in lupus have not been thoroughly investigated, and only recently a CD27− memory B cell subset was identified in the peripheral blood of lupus patients. Focusing on CD27− B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE. Methods: Three independent cohorts of lupus patients were used to characterize CD27− memory B cells, using multiparameter flow cytometry and single‐cell reverse transcription–polymerase chain reaction of heavy‐chain transcripts. Results: We identified a homogeneous subset of CD27−,IgD−,CD95+ memory B cells with an activated phenotype that was increased in patients with disease flares and that correlated with disease activity and serologic abnormalities. In contrast, the entire subset of CD27−,IgD− B cells was found to be heterogeneous, did not correlate significantly with lupus activity, and was also increased in patients with bacterial infections. Conclusion: We conclude that CD95 is a useful marker to identify CD27− memory B cells with an activated phenotype, which might serve as a biomarker for lupus activity and as a target of further investigations aiming to elucidate the pathogenic potential of these cells and the mechanisms involved in the generation as well as regulation of this CD27−,IgD−,CD95+ memory B cell subset.
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Cites
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Derivation of the sledai. A disease activity index for lupus patients
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Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus
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Self-citationIdentification and characterization of circulating human transitional B cells
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Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus
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Cited by
Immunopathogenic mechanisms of systemic autoimmune disease
Wahren-Herlenius, M., & Dörner, T. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60954-x · Cited by 593
Self-citationIL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
Wang, S., Wang, J., Kumar, V., Karnell, J. L., Naiman, B., Gross, P. S., Rahman, S., Zerrouki, K., Hanna, R., Morehouse, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03750-7 · Cited by 578
Sanz, I., Wei, C., Jenks, S. A., Cashman, K. S., Tipton, C., Woodruff, M. C., Hom, J., & Lee, F. E.-H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02458 · Cited by 569
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Self-citationHoffman, W., Lakkis, F. G., & Chalasani, G. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 482
Metadata
- Authors
- Jacobi, A. M., Reiter, K., Mackay, M., Aranow, C., Hiepe, F., Radbruch, A., Hansen, A., Burmester, G., Diamond, B., Lipsky, P. E., & Dörner, T.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2008-05-31
- Volume
- 58
- Issue
- 6
- Pages
- 1762-1773
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1967380173
- Cited by
- 289
- References
- 31
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95. https://app.cochat.ai/papers/10.1002/art.23498
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- Jacobi, A. M., Reiter, K., Mackay, M., Aranow, C., Hiepe, F., Radbruch, A., Hansen, A., Burmester, G., Diamond, B., Lipsky, P. E., & Dörner, T. (2008). Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95. Arthritis & Rheumatism. https://doi.org/10.1002/art.23498
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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