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Cited by 484Gout, Hyperuricemia, Uric AcidAcute Ischemic Stroke ManagementDiet, Metabolism, and Disease

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Hyperuricemia and risk of stroke: A systematic review and meta‐analysis

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Kim, Seo Young, Guevara, James P., Kim, Kyoung Mi, Choi, Hyon K., Heitjan, Daniel F., Albert, Daniel A.·2009·Arthritis Care & Research
DOI 10.1002/art.24612PMC PMC2714267
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Abstract

Objective: To assess the association between hyperuricemia and risk of stroke incidence and mortality because hyperuricemia is hypothesized to be a risk factor for stroke and other cardiovascular disease, but, to date, results from observational studies are conflicting. Methods: A systematic review and meta‐analysis were conducted. Studies were identified by searching major electronic databases using the Medical Subject Headings and keywords without restriction in languages. Prospective cohort studies were included only if they contained data on stroke incidences or mortalities related to serum uric acid levels in adults. Pooled risk ratios (RRs) for the association of stroke incidence and mortality with serum uric acid levels were calculated. Results: A total of 16 studies including 238,449 adults were eligible and abstracted. Hyperuricemia was associated with a significantly higher risk of both stroke incidence (6 studies; RR 1.41, 95% confidence interval [95% CI] 1.05, 1.76) and mortality (6 studies; RR 1.36, 95% CI 1.03, 1.69) in our meta‐analyses of unadjusted study estimates. Subgroup analyses of studies adjusting for known risk factors such as age, hypertension, diabetes mellitus, and cholesterol still showed that hyperuricemia was significantly associated with both stroke incidence (4 studies; RR 1.47, 95% CI 1.19, 1.76) and mortality (6 studies; RR 1.26, 95% CI 1.12, 1.39). The pooled estimate of multivariate RRs did not differ significantly by sex. Conclusion: Hyperuricemia may modestly increase the risks of both stroke incidence and mortality. Future research is needed to determine whether lowering uric acid level has any beneficial effects on stroke.

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Metadata

Authors
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A.
Affiliations
  • Children's Hospital of Philadelphia (US)
  • Pusan National University (KR)
  • University of British Columbia (CA)
  • University of Pennsylvania (US)
  • Dartmouth–Hitchcock Medical Center (US)
ORCID
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2009-06-29
Volume
61
Issue
7
Pages
885-892
ISSN
  • 0893-7524 (ISSN-L)
  • 1529-0123
DOI
10.1002/art.24612
PMC
PMC2714267
OpenAlex
W2002849282
Cited by
484
References
62
Citations by year
2026: 11 · 2025: 15 · 2024: 21 · 2023: 21 · 2022: 25 · 2021: 36 · 2020: 32 · 2019: 28 · 2018: 23 · 2017: 29 · 2016: 42 · 2015: 55 · 2014: 29 · 2013: 40 · 2012: 30
FWCI
3.66
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Arthritis Care & Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32AR007442)
Topics
  • Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
hyperuricemia, serum uric acid, stroke incidence, stroke mortality, cardiovascular risk factors, hypertension, diabetes mellitus, cholesterol, sex differences
MeSH terms
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Risk Factors, Uric Acid, Incidence, Stroke, Hyperuricemia, Young Adult

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