The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Essential role of microRNA‐155 in the pathogenesis of autoimmune arthritis in mice
Open accessAbstract
Objective: MicroRNAs (miRNA) are a new class of regulatory elements. Altered expression of miRNA has been demonstrated in the inflamed joints of patients with rheumatoid arthritis (RA). The aim of this study was to examine the role of miRNA in the pathogenesis of autoimmune arthritis, using 2 murine models. Methods: Collagen‐induced arthritis (CIA) and K/BxN serum‐transfer arthritis were induced in wild‐type (WT) and miR‐155–deficient (miR‐155 −/− ) mice. The severity of arthritis was determined clinically and histologically. Anticollagen antibodies and cytokines were measured by enzyme‐linked immunosorbent assay. The cellular composition of the draining lymph nodes after induction of CIA was measured by flow cytometry. Results: The miR‐155 −/− mice did not develop CIA. Deficiency in miR‐155 prevented the generation of pathogenic autoreactive B and T cells, since anticollagen antibodies and the expression levels of antigen‐specific T cells were strongly reduced in miR‐155 −/− mice. Moreover, Th17 polarization of miR‐155 −/− mouse T cells was impaired, as shown by a significant decrease in the levels of interleukin‐17 (IL‐17) and IL‐22. In the K/BxN serum‐transfer arthritis model, which only depends on innate effector mechanisms, miR‐155 −/− mice showed significantly reduced local bone destruction, attributed to reduced generation of osteoclasts, although the severity of joint inflammation was similar to that in WT mice. Conclusion: These results demonstrate that miR‐155 is essentially involved in the adaptive and innate immune reactions leading to autoimmune arthritis, and therefore miR‐155 might provide a novel target for the treatment of patients with RA.
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Cites
Origins and Mechanisms of miRNAs and siRNAs
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Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis
Lipsky, P. E., van der Heijde, D. M. F. M., St. Clair, E. W., Furst, D. E., Breedveld, F. C., Kalden, J. R., Smolen, J. S., Weisman, M., Emery, P., Feldmann, M., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011303432202 · Cited by 2,996
Self-citationMany roads to maturity: microRNA biogenesis pathways and their regulation
Winter, J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009) · Nature Cell Biology · doi:10.1038/ncb0309-228 · Cited by 2,656
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2094 · Cited by 2,529
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866
Requirement of bic/microRNA-155 for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833
Regulation of the Germinal Center Response by MicroRNA-155
Thai, T.-H., Calado, D. P., Casola, S., Ansel, K. M., Xiao, C., Xue, Y., Murphy, A., Frendewey, D., Valenzuela, D., Kutok, J. L., et al. (2007) · Science · doi:10.1126/science.1141229 · Cited by 1,477
Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
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Self-citationPhysiological and pathological roles for microRNAs in the immune system
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Cited by
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30173-8 · Cited by 4,870
Self-citationInflammatory bone loss: pathogenesis and therapeutic intervention
Redlich, K., & Smolen, J. S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3669 · Cited by 830
Self-citationSong, H., Li, X., Zhao, Z., Qian, J., Wang, Y., Cui, J., Weng, W., Cao, L., Chen, X., Hu, Y., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00287 · Cited by 303
Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis
Murugaiyan, G., Beynon, V., Mittal, A., Joller, N., & Weiner, H. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003952 · Cited by 289
Metadata
- Authors
- Blüml, S., Bonelli, M., Niederreiter, B., Puchner, A., Mayr, G., Hayer, S., Koenders, M. I., van den Berg, W. B., Smolen, J., & Redlich, K.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2011-04-27
- Volume
- 63
- Issue
- 5
- Pages
- 1281-1288
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1988140132
- Cited by
- 253
- References
- 34
- FWCI
- 17.91
- Type
- journal article
- Language
- en
- Open access
- green
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