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Cited by 289Multiple Sclerosis Research StudiesMicroRNA in disease regulationT-cell and B-cell Immunology

Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis

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Murugaiyan, Gopal, Beynon, Vanessa, Mittal, Akanksha, Joller, Nicole, Weiner, Howard L·2011·The Journal of Immunology
DOI 10.4049/jimmunol.1003952PMC PMC3167080
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Abstract

IFN-γ–producing Th1 and IL-17–producing Th17 cells are the key participants in various autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Although both of these T cell subsets are known to be regulated by specific transcription factors and cytokines, the role of microRNAs that control these two inflammatory T cell subsets and whether targeting microRNAs can have therapeutic effects are not known. In this study, we show that microRNA-155 (Mir-155) expression is elevated in CD4+ T cells during EAE, and Mir-155−/− mice had a delayed course and reduced severity of disease and less inflammation in the CNS. The attenuation of EAE in Mir-155−/− mice was associated with a decrease in Th1 and Th17 responses in the CNS and peripheral lymphoid organs. The T cell-intrinsic function of Mir-155−/− was demonstrated by the resistance of Mir-155−/− CD4+ T cell-repleted Rag-1−/− mice to EAE. Finally, we found that anti–Mir-155 treatment reduced clinical severity of EAE when given before and after the appearance of clinical symptoms. These findings demonstrate that Mir-155 confers susceptibility to EAE by affecting inflammatory T cell responses and identify Mir-155 as a new target for therapeutic intervention in multiple sclerosis.

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  • miR-155 knockout ameliorates experimental autoimmune encephalomyelitis in a murine model of multiple sclerosis.

    “it was shown that knock-out of miR-155 ameliorates experimental autoimmune encephalomyelitis in a murine model of multiple sclerosis [250].”

    From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [250]

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Authors
Murugaiyan, G., Beynon, V., Mittal, A., Joller, N., & Weiner, H. L.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2011-09-01
Volume
187
Issue
5
Pages
2213-2221
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.1003952
PMC
PMC3167080
OpenAlex
W2143308901
Cited by
289
References
2
Citations by year
2026: 4 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 20 · 2021: 11 · 2020: 29 · 2019: 10 · 2018: 15 · 2017: 21 · 2016: 24 · 2015: 36 · 2014: 33 · 2013: 32 · 2012: 18
FWCI
19.13
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Multiple Sclerosis Society
  • Schweizerische Multiple Sklerose Gesellschaft
  • National Institutes of Health (AI043458, NS038037)
  • National Institute of Allergy and Infectious Diseases (AI043458, R01AI043458)
  • National Institute of Neurological Disorders and Stroke (NS23132, R01NS023132, NS038037, P01NS038037)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
miR-155, experimental autoimmune encephalomyelitis, multiple sclerosis, Th1 cells, Th17 cells, CD4+ T cells, microRNA knockout mice, neuroinflammation, T cell reconstitution, disease susceptibility
MeSH terms
Animals, Encephalomyelitis, Autoimmune, Experimental, Inflammation, Mice, Inbred C57BL, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Gene Silencing, MicroRNAs, Mice

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