Cited by 18Systemic Lupus Erythematosus ResearchVasculitis and related conditionsHeat shock proteins research

Association of autoantibodies to heat‐shock protein 60 with arterial vascular events in patients with antiphospholipid antibodies

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Dieudé, Mélanie, Correa, José A., Neville, Carolyn, Pineau, Christian, Levine, Jerrold S., Subang, Rebecca, Landolt‐Marticorena, Carolina, Su, Jiandong +4 more·2011·Arthritis & Rheumatism

Abstract

Objective: Anti–heat shock protein 60 autoantibodies (anti‐Hsp60) are associated with cardiovascular disease and are known to affect endothelial cells in vitro, and we have recently shown that anti‐Hsp60 promote thrombosis in a murine model of arterial injury. Based on those findings, we undertook the present study to investigate the hypothesis that the presence of anti‐Hsp60, alone or in combination with other thrombogenic risk factors, is associated with an elevated risk of vascular events. Methods: The study population was derived from 3 ongoing cohort studies: 2 independent systemic lupus erythematosus (SLE) registries and 1 cohort comprising SLE patients and non‐SLE patients. Data from a total of 402 participants were captured; 199 of these participants had had confirmed vascular events (arterial vascular events in 102, venous vascular events in 76, and both arterial and venous vascular events in 21). Anti‐Hsp60 were detected by enzyme‐linked immunoassay, and association with vascular events was assessed by regression analysis. Results: Multiple regression analysis revealed that arterial vascular events were associated with male sex, age, and hypertension. Analyses of the vascular events according to their origin showed an association of anti‐Hsp60 with arterial vascular events (odds ratio 2.26 [95% confidence interval 1.13–4.52]), but not with venous vascular events. Anti‐Hsp60 increased the risk of arterial vascular events (odds ratio 5.54 [95% confidence interval 1.89–16.25]) in antiphospholipid antibody (aPL)–positive, but not aPL‐negative, individuals. Conclusion: We demonstrate that anti‐Hsp60 are associated with an increased risk of arterial vascular events, but not venous vascular events, in aPL‐positive individuals. These data suggest that anti‐Hsp60 may serve as a useful biomarker to distinguish risk of arterial and venous vascular events in patients with aPL.

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Crossref · 10.1002/art.30411

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Authors
Dieudé, M., Correa, J. A., Neville, C., Pineau, C., Levine, J. S., Subang, R., Landolt‐Marticorena, C., Su, J., Kassis, J., Solymoss, S., Fortin, P. R., & Rauch, J.
Affiliations
  • McGill University Health Centre (CA)
  • McGill University (CA)
  • University of Illinois Chicago (US)
  • University Health Network (CA)
  • Hôpital Maisonneuve-Rosemont (CA)
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
2011-08
Volume
63
Issue
8
Pages
2416-2424
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
OpenAlex
W2027943582
Cited by
18
References
41
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.93
Type
journal article
Language
en
Open access
Locations
  • Arthritis & Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Canadian Institutes of Health Research (64336, 97916, 49509_1, 64336_1, MOP-42391)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
antiphospholipid antibodies, systemic lupus erythematosus, thrombosis, cardiovascular risk, biomarkers, hypertension, endothelial cells
MeSH terms
Autoantibodies, Female, Humans, Hypertension, Lupus Erythematosus, Systemic, Male, Risk Factors, Vascular Diseases, Cohort Studies, Antibodies, Antiphospholipid, Chaperonin 60

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