IgA anti-β2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus
Open accessAbstract
BACKGROUND: The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial. METHODOLOGY/PRINCIPAL FINDINGS: To address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospholipid syndrome, then an association with thromboembolic events should manifest in patients whose only aPL is of IgA isotype. We performed a retrospective chart review of 56 patients (31 with systemic lupus erythematosus [SLE] and 25 without SLE) whose only positive aPL was IgA anti-beta2-glycoprotein I (isolated IgA anti-beta2GPI) and compared their clinical features with 56 individually matched control patients without any aPL. Patients with isolated IgA anti-beta2GPI had a significantly increased number of thromboembolic events, as compared to controls. When patients were stratified into those with and without SLE, the association between isolated IgA anti-beta2GPI and thromboembolic events persisted for patients with SLE, but was lost for those without SLE. Titers of IgA anti-beta2GPI were significantly higher in SLE patients who suffered a thromboembolic event. Among patients with isolated IgA anti-beta2GPI, there was an increased prevalence of diseases or morbidities involving organs of mucosal immunity (i.e., gastrointestinal system, pulmonary system, and skin). CONCLUSIONS/SIGNIFICANCE: The presence of isolated IgA anti-beta2GPI is associated with an increased risk of thromboembolic events, especially among patients with SLE. IgA anti-beta2GPI is associated with an increased prevalence of morbidities involving organs of mucosal immunity.
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In patients with isolated IgA anti-β2-glycoprotein I positivity, the increased risk for thromboembolic events was observed only in patients with SLE.
“In a study of patients with isolated IgA anti-β2-glycoprotein I positivity, the increased risk for thromboembolic events was observed only in patients with SLE [37].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [37]
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Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus
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- Authors
- Sweiss, N. J., Bo, R., Kapadia, R., Manst, D., Mahmood, F., Adhikari, T., Volkov, S., Badaracco, M., Smaron, M., Chang, A., Baron, J., & Levine, J. S.
- Affiliations
- University of Chicago (US)
- University of Southern California (US)
- Loyola University Chicago (US)
- University of Cincinnati Medical Center (US)
- University of Illinois Chicago (US)
- Corresponding author
- Sweiss, Nadera J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-19
- Volume
- 5
- Issue
- 8
- Pages
- e12280
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2924386
- OpenAlex
- W2066133643
- Cited by
- 56
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Knowledge@UChicago (University of Chicago) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Chicago (cc-by)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid antibodies, antiphospholipid syndrome, systemic lupus erythematosus, thromboembolic events, thrombosis risk, mucosal immunity, gastrointestinal diseases, lung disease, skin diseases
- MeSH terms
- Adult, Aged, Autoantibodies, Disease Susceptibility, Female, Humans, Immunoglobulin A, Lupus Erythematosus, Systemic, Male, Middle Aged, Retrospective Studies, Thromboembolism, Comorbidity, Immunity, Mucosal, beta 2-Glycoprotein I, Young Adult
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