How do we establish a biological marker for a behaviorally defined disorder? Autism as a test case
Open accessAbstract
We discuss the recent push to develop support vector machines and other cluster analyses as a means for biological signatures as early screens for autism. These methods not only hold great promise but also require careful consideration prior to implementation. We outline three validity tests and potential methods for addressing them. Autism Res 2011,4:239–241. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.
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For a biomarker to be developed, it must be demonstrated that the marker is present before the onset of symptoms, and that it is specific to the disorder.
“In order for a biomarker to be developed, it must be demonstrated that the marker is present before the onset of symptoms, and that it is specific to the disorder.13”
From Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder (2017) · cites this paper as [13]
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White matter pathology in phenylketonuria☆
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- Authors
- Yerys, B. E., & Pennington, B. F.
- Venue
- Autism Research
- Publisher
- Wiley
- Published
- 2011-06-24
- Volume
- 4
- Issue
- 4
- Pages
- 239-241
- ISSN
- 1939-3792 (ISSN-L)
- 1939-3806
- OpenAlex
- W2005176066
- Cited by
- 24
- References
- 11
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autism Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K23MH086111)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- autism spectrum disorder, biomarkers, support vector machine, clustering, early screening, diagnostic validity, behavioral disorders
- MeSH terms
- Autistic Disorder, Brain, Child, Preschool, Humans, Infant, Mass Screening, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Diffusion Magnetic Resonance Imaging
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