Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

Membrane transporters in drug development

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A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

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Carnitine—metabolism and functions

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Functional variants of OCTN cation transporter genes are associated with Crohn disease

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Carnitine biosynthesis in mammals

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Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2

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An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

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Discovery of the ergothioneine transporter

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Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

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Disorders of carnitine transport and the carnitine cycle

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Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1

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Effect of γ-butyrobetaine on fatty liver in juvenile visceral steatosis mice

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cDNA Sequence, Transport Function, and Genomic Organization of Human OCTN2, a New Member of the Organic Cation Transporter Family

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Oxaliplatin-safety profile: neurotoxicity

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Novel Membrane Transporter OCTN1 Mediates Multispecific, Bidirectional, and pH-Dependent Transport of Organic Cations

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Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice

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Na+-Dependent Carnitine Transport by Organic Cation Transporter (OCTN2): Its Pharmacological and Toxicological Relevance

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Interaction of Imatinib with Human Organic Ion Carriers

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Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.

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Regional Distribution of Solute Carrier mRNA Expression Along the Human Intestinal Tract

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Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa

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Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

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Rapid Report

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Molecular Identification of a Novel Carnitine Transporter Specific to Human Testis

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Molecular and Physiological Evidence for Multifunctionality of Carnitine/Organic Cation Transporter OCTN2

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Nephrotoxicity of platinum complexes is related to basolateral organic cation transport

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β-Lactam Antibiotics as Substrates for OCTN2, an Organic Cation/Carnitine Transporter

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Functional relevance of carnitine transporter OCTN2 to brain distribution of l ‐carnitine and acetyl‐ l ‐carnitine across the blood–brain barrier

Kido, Y., Tamai, I., Ohnari, A., Sai, Y., Kagami, T., Nezu, J., Nikaido, H., Hashimoto, N., Asano, M., & Tsuji, A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00621.x · Cited by 169 · see citing works

Na+-coupled transport of l-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney

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Maternal-fetal carnitine relationship and neonatal ketosis in the rat.

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Carnitine transport: Pathophysiology and metabolism of known molecular defects

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Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons

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Effects of Genetic Variation in the Novel Organic Cation Transporter, OCTN1, on the Renal Clearance of Gabapentin

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Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2° strain of mouse with similarities to Reye's syndrome

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Uptake of Cardiovascular Drugs Into the Human Heart

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Involvement of OCTN1 (SLC22A4) in pH-Dependent Transport of Organic Cations

Tamai, I., Nakanishi, T., Kobayashi, D., China, K., Kosugi, Y., Nezu, J., Sai, Y., & Tsuji, A. (2003) · Molecular Pharmaceutics · doi:10.1021/mp0340082 · Cited by 113 · see citing works

Epithelial Organic Cation Transporters Ensure pH-Dependent Drug Absorption in the Airway

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EXPRESSION, LOCALIZATION, AND FUNCTION OF THE CARNITINE TRANSPORTER OCTN2 (SLC22A5) IN HUMAN PLACENTA

Grube, M., zu Schwabedissen, H. E. M., Draber, K., Präger, D., Möritz, K.-U., Linnemann, K., Fusch, C., Jedlitschky, G., & Kroemer, H. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.001560 · Cited by 111 · see citing works

Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption

Nakamura, T., Nakanishi, T., Haruta, T., Shirasaka, Y., Keogh, J. P., & Tamai, I. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900206j · Cited by 102 · see citing works

Carnitine uptake into human heart cells in culture

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PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2

Kato, Y., Sai, Y., Yoshida, K., Watanabe, C., Hirata, T., & Tsuji, A. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.002212 · Cited by 95 · see citing works

Carnitine: Metabolism and clinical chemistry

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Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse

Kato, Y., Sugiura, M., Sugiura, T., Wakayama, T., Kubo, Y., Kobayashi, D., Sai, Y., Tamai, I., Iseki, S., & Tsuji, A. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.024158 · Cited by 91 · see citing works

Role of organic cation transporters in drug-induced toxicity

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Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia

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Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract

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The Carnitine Transporter SLC22A5 Is Not a General Drug Transporter, but It Efficiently Translocates Mildronate

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Acetyl‐ L ‐carnitine permeability across the blood–brain barrier and involvement of carnitine transporter OCTN2

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Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency

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Membrane transport function in primary cultures of human proximal tubular cells

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Salbutamol is actively absorbed across human bronchial epithelial cell layers

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Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood–brain barrier

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Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein

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Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

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Decreased Tissue Distribution of l-Carnitine in Juvenile Visceral Steatosis Mice

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PDZK1 Regulates Two Intestinal Solute Carriers (Slc15a1 and Slc22a5) in Mice

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Functional Characterization of Ergothioneine Transport by Rat Organic Cation/Carnitine Transporter Octn1 (slc22a4)

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Carnitine transport in human intestinal biopsy specimens

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The Effect of Valproic Acid on Plasma Carnitine Levels

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Mechanism of the Regulation of Organic Cation/Carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines

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Carnitine transport in rat small intestine

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Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro

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Organic Cation/Carnitine Transporter, OCTN2, Is Differentially Expressed in the Adult Rat Epididymis1

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Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil

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High Uptake of [2-11C]Acetyl-l-Carnitine into the Brain: A Pet Study

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Gene-Dose Effect on Carnitine Transport Activity in Embryonic Fibroblasts of JVS Mice as a Model of Human Carnitine Transporter Deficiency

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Carnitine Content of Blood and Amniotic Fluid

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Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa

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Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

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Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans

Nakanishi, T., Haruta, T., Shirasaka, Y., & Tamai, I. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.035402 · Cited by 40 · see citing works

Deficient Muscle Carnitine Transport in Primary Carnitine Deficiency

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OCTN2-mediated transport of carnitine in isolated Sertoli cells

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Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice

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Carnitine transport into muscular cells. inhibition of transport and cell growth by mildronate

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Sodium-dependent carnitine transport in human placental choriocarcinoma cells

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Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis

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Involvement of OCTN2 and B0,+in the transport of carnitine through anin vitromodel of the blood–brain barrier

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OCTN2-Mediated Carnitine Uptake in a Newly Discovered Human Proximal Tubule Cell Line (Caki-1)

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Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice

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