The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Seeking causes: Classifying and evaluating congenital heart defects in etiologic studies
Abstract
BACKGROUND: Classification and analysis of congenital heart defects (CHD) in etiologic studies is particularly challenging because of diversity of cardiac phenotypes and underlying developmental mechanisms. We describe an approach to classification for risk assessment of CHD based on developmental and epidemiologic considerations, and apply it to data from the National Birth Defect Prevention Study (NBDPS). METHODS: The classification system incorporated the three dimensions of cardiac phenotype, cardiac complexity, and extracardiac anomalies. The system was designed to facilitate the assessment of simple isolated defects and common associations. A team with cardiologic expertise applied the system to a large sample from the NBDPS. RESULTS: Of the 4,703 cases of CHDs in the NBDPS with birth years 1997 through 2002, 63.6% were simple, isolated cases. Specific associations of CHDs represented the majority of the remainder. The mapping strategy generated relatively large samples for most cardiac phenotypes and provided enough detail to isolate important subgroups of CHDs that may differ by etiology or mechanism. CONCLUSIONS: Classification of CHDs that considers cardiac and extracardiac phenotypes is practically feasible, and yields manageable groups of well‐characterized phenotypes. Although best suited for large studies, this approach to classification and analysis can be a flexible and powerful tool in many types of etiologic studies of heart defects. Birth Defects Research (Part A), 2007. © 2007 Wiley‐Liss, Inc.
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Cites
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Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5
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Prevalence of congenital heart disease
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Jenkins, K. J., Correa, A., Feinstein, J. A., Botto, L., Britt, A. E., Daniels, S. R., Elixson, M., Warnes, C. A., & Webb, C. L. (2007) · Circulation · doi:10.1161/circulationaha.106.183216 · Cited by 818
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Self-citationThe National Birth Defects Prevention Study
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Cited by
Liu, Y., Chen, S., Zühlke, L., Black, G. C., Choy, M.-K., Li, N., & Keavney, B. D. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz009 · Cited by 1,436
Survival in Children With Congenital Heart Disease: Have We Reached a Peak at 97%?
Mandalenakis, Z., Giang, K. W., Eriksson, P., Liden, H., Synnergren, M., Wåhlander, H., Fedchenko, M., Rosengren, A., & Dellborg, M. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.017704 · Cited by 430
Talens, R. P., Christensen, K., Putter, H., Willemsen, G., Christiansen, L., Kremer, D., Suchiman, H. E. D., Slagboom, P. E., Boomsma, D. I., & Heijmans, B. T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00835.x · Cited by 300
Liu, S., Joseph, K. S., Lisonkova, S., Rouleau, J., Van den Hof, M., Sauve, R., & Kramer, M. S. (2013) · Circulation · doi:10.1161/circulationaha.112.001054 · Cited by 272
Interleukin‐6 promotes tumorigenesis by altering DNA methylation in oral cancer cells
Gasche, J. A., Hoffmann, J., Boland, C. R., & Goel, A. (2011) · International Journal of Cancer · doi:10.1002/ijc.25764 · Cited by 178
Metadata
- Authors
- Botto, L. D., Lin, A. E., Riehle‐Colarusso, T., Malik, S., & Correa, A.
- Venue
- Birth Defects Research Part A: Clinical and Molecular Teratology
- Publisher
- Wiley
- Published
- 2007-08-29
- Volume
- 79
- Issue
- 10
- Pages
- 714-727
- ISSN
- 1542-0752 (ISSN-L)
- 1542-0760
- OpenAlex
- W2162347038
- Cited by
- 469
- References
- 34
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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