The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
New insights into elastic fiber assembly
Abstract
Elastic fibers provide recoil to tissues that undergo repeated stretch, such as the large arteries and lung. These large extracellular matrix (ECM) structures contain numerous components, and our understanding of elastic fiber assembly is changing as we learn more about the various molecules associated with the assembly process. The main components of elastic fibers are elastin and microfibrils. Elastin makes up the bulk of the mature fiber and is encoded by a single gene. Microfibrils consist mainly of fibrillin, but also contain or associate with proteins such as microfibril associated glycoproteins (MAGPs), fibulins, and EMILIN‐1. Microfibrils were thought to facilitate alignment of elastin monomers prior to cross‐linking by lysyl oxidase (LOX). We now know that their role, as well as the overall assembly process, is more complex. Elastic fiber formation involves elaborate spatial and temporal regulation of all of the involved proteins and is difficult to recapitulate in adult tissues. This report summarizes the known interactions between elastin and the microfibrillar proteins and their role in elastic fiber assembly based on in vitro studies and evidence from knockout mice. We also propose a model of elastic fiber assembly based on the current data that incorporates interactions between elastin, LOXs, fibulins and the microfibril, as well as the pivotal role played by cells in structuring the final functional fiber. Birth Defects Research (Part C) 81:229–240, 2007. © 2008 Wiley‐Liss, Inc.
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Cites
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Neptune, E. R., Frischmeyer, P. A., Arking, D. E., Myers, L., Bunton, T. E., Gayraud, B., Ramirez, F., Sakai, L. Y., & Dietz, H. C. (2003) · Nature Genetics · doi:10.1038/ng1116 · Cited by 1,404
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H., & Hynes, R. O. (1993) · Development · doi:10.1242/dev.119.4.1079 · Cited by 1,305
Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.
Sakai, L. Y., Keene, D. R., & Engvall, E. (1986) · The Journal of cell biology · doi:10.1083/jcb.103.6.2499 · Cited by 1,157
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
Kagan, H. M., & Li, W. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10413 · Cited by 954
Kielty, C. M., Sherratt, M. J., & Shuttleworth, C. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.14.2817 · Cited by 841
Fibronectin fibrillogenesis, a cell-mediated matrix assembly process
Mao, Y., & Schwarzbauer, J. E. (2005) · Matrix Biology · doi:10.1016/j.matbio.2005.06.008 · Cited by 816
Elastin is an essential determinant of arterial morphogenesis
Li, D. Y., Brooke, B., Davis, E. C., Mecham, R. P., Sorensen, L. K., Boak, B. B., Eichwald, E., & Keating, M. T. (1998) · Nature · doi:10.1038/30522 · Cited by 790
Self-citationA Lamellar Unit of Aortic Medial Structure and Function in Mammals
WOLINSKY, H., & GLAGOV, S. (1967) · Circulation Research · doi:10.1161/01.res.20.1.99 · Cited by 742
Common Sequence Variants in the LOXL1 Gene Confer Susceptibility to Exfoliation Glaucoma
Thorleifsson, G., Magnusson, K. P., Sulem, P., Walters, G. B., Gudbjartsson, D. F., Stefansson, H., Jonsson, T., Jonasdottir, A., Jonasdottir, A., Stefansdottir, G., et al. (2007) · Science · doi:10.1126/science.1146554 · Cited by 677
Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes
Lee, B., Godfrey, M., Vitale, E., Hori, H., Mattei, M.-G., Sarfarazi, M., Tsipouras, P., Ramirez, F., & Hollister, D. W. (1991) · Nature · doi:10.1038/352330a0 · Cited by 671
Cited by
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Extracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598
Extracellular Matrix Assembly: A Multiscale Deconstruction
Mouw, J. K., Ou, G., & Weaver, V. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3902 · Cited by 1,534
The myofibroblast matrix: implications for tissue repair and fibrosis
Klingberg, F., Hinz, B., & White, E. S. (2013) · The Journal of Pathology · doi:10.1002/path.4104 · Cited by 776
Burgstaller, G., Oehrle, B., Gerckens, M., White, E. S., Schiller, H. B., & Eickelberg, O. (2017) · European Respiratory Journal · doi:10.1183/13993003.01805-2016 · Cited by 482
Metadata
- Authors
- Wagenseil, J. E., & Mecham, R. P.
- Venue
- Birth Defects Research Part C: Embryo Today: Reviews
- Publisher
- Wiley
- Published
- 2007-12
- Volume
- 81
- Issue
- 4
- Pages
- 229-240
- ISSN
- 1542-975X (ISSN-L)
- 1542-9768
- OpenAlex
- W2146275594
- Cited by
- 420
- References
- 100
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
