The myofibroblast matrix: implications for tissue repair and fibrosis

Cellular and molecular mechanisms of fibrosis

Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495 · see citing works

The extracellular matrix at a glance

Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334 · see citing works

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works

The Extracellular Matrix: Not Just Pretty Fibrils

Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527 · see citing works

Taking Cell-Matrix Adhesions to the Third Dimension

Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027 · see citing works

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,666 · see citing works

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653 · see citing works

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,226 · see citing works

The Myofibroblast

Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068 · see citing works

Pathogenesis of Liver Fibrosis

Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809 · see citing works

Formation and function of the myofibroblast during tissue repair

Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658 · see citing works

Making sense of latent TGFβ activation

Annes, J. P., Munger, J. S., & Rifkin, D. B. (2002) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,624 · see citing works

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569 · see citing works

Negative regulation of transforming growth factor-β by the proteoglycan decorin

Yamaguchi, Y., Mann, D. M., & Ruoslahti, E. (1990) · Nature · doi:10.1038/346281a0 · Cited by 1,516 · see citing works

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

Gabbiani, G., Ryan, G. B., & Majno, G. (1971) · Experientia · doi:10.1007/bf02147594 · Cited by 1,485 · see citing works

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

Humphreys, B. D., Lin, S., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,447 · see citing works

Transglutaminases: crosslinking enzymes with pleiotropic functions

Lorand, L., & Graham, R. M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1014 · Cited by 1,439 · see citing works

Inflammatory cells during wound repair: the good, the bad and the ugly

Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340 · cited 1× · see citing works

Integrating mechanisms of pulmonary fibrosis

Wynn, T. A. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110551 · Cited by 1,282 · see citing works

Recent Developments in Myofibroblast Biology

Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., & Gabbiani, G. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.004 · Cited by 1,193 · see citing works

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

Crawford, S. E., Stellmach, V. M., Murphy-Ullrich, J. E., Ribeiro, S. M. F., Lawler, J., Hynes, R. O., Boivin, G. P., & Bouck, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81460-9 · Cited by 1,176 · see citing works

Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring

Shah, M., Foreman, D. M., & Ferguson, M. W. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.3.985 · Cited by 1,168 · see citing works

Systemic sclerosis: a prototypic multisystem fibrotic disorder

Varga, J., & Abraham, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31139 · Cited by 1,164 · see citing works

Interactions between extracellular matrix and growth factors in wound healing

Schultz, G. S., & Wysocki, A. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00466.x · Cited by 1,126 · see citing works

Cardiac fibroblasts: At the heart of myocardial remodeling

Porter, K. E., & Turner, N. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.002 · Cited by 997 · see citing works

Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor β

Hildebrand, A., Romarı́s, M., Rasmussen, L. M., Heinegård, D. K., Twardzik, D. R., Border, W. A., & Ruoslahti, E. I. (1994) · Biochemical Journal · doi:10.1042/bj3020527 · Cited by 995 · see citing works

Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products

Verzijl, N., DeGroot, J., Thorpe, S. R., Bank, R. A., Shaw, J., Lyons, T. J., Bijlsma, J. W. J., Lafeber, F. P. J. G., Baynes, J., & TeKoppele, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006700200 · Cited by 964 · see citing works

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870 · see citing works

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

Serini, G., Bochaton-Piallat, M.-L., Ropraz, P., Geinoz, A., Borsi, L., Zardi, L., & Gabbiani, G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.3.873 · Cited by 847 · see citing works

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

Lin, S., Kisseleva, T., Brenner, D. A., & Duffield, J. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080433 · Cited by 845 · see citing works

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 799 · see citing works

Myocardial remodeling after infarction: the role of myofibroblasts

van den Borne, S. W. M., Dı́ez, J., Blankesteijn, W. M., Verjans, J. W. H., Hofstra, L., & Narula, J. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.199 · Cited by 737 · see citing works

Diastolic Stiffness of the Failing Diabetic Heart: Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension

van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.728550 · Cited by 723 · see citing works

Stromal myofibroblasts are drivers of invasive cancer growth

De Wever, O., Demetter, P., Mareel, M., & Bracke, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23925 · Cited by 722 · see citing works

The myofibroblast: Paradigm for a mechanically active cell

Hinz, B. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 695 · see citing works

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for <i>In Vitro</i> Investigation

Booth, A. J., Hadley, R., Cornett, A. M., Dreffs, A. A., Matthes, S. A., Tsui, J. L., Weiss, K., Horowitz, J. C., Fiore, V. F., Barker, T. H., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0754oc · Cited by 665 · see citing works

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

Jun, J.-I., & Lau, L. F. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3599 · Cited by 606 · see citing works

The origin of fibroblasts and mechanism of cardiac fibrosis

Krenning, G., Zeisberg, E. M., & Kalluri, R. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22322 · Cited by 601 · see citing works

Lysyl oxidase: Properties, regulation and multiple functions in biology

Smith‐Mungo, L. I., & Kagan, H. M. (1998) · Matrix Biology · doi:10.1016/s0945-053x(98)90012-9 · Cited by 581 · see citing works

Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders

Piera-Velazquez, S., Li, Z., & Jimenez, S. A. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.001 · Cited by 580 · see citing works

Tenascins: regulation and putative functions during pathological stress

Chiquet-Ehrismann, R., & Chiquet, M. (2003) · Journal of Pathology · doi:10.1002/path.1415 · Cited by 557 · see citing works

Fibronectins

Hynes, R. O. (1990) · Springer series in molecular biology · doi:10.1007/978-1-4612-3264-3 · Cited by 540 · see citing works

Molecular Targets in Pulmonary Fibrosis

Scotton, C. J., & Chambers, R. C. (2007) · CHEST Journal · doi:10.1378/chest.06-2568 · Cited by 533 · see citing works

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

Cirri, P., & Chiarugi, P. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9340-x · Cited by 515 · see citing works

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

Wipff, P., & Hinz, B. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.012 · Cited by 514 · see citing works

Transglutaminases: Protein Cross-Linking Enzymes in Tissues and Body Fluids

Aeschlimann, D. P., & Paulsson, M. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1642451 · Cited by 503 · see citing works

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

Zhang, K., Rekhter, M. D., Gordon, D., & Phan, S. H. (1994) · PubMed Central · Cited by 477 · see citing works

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

Kalamajski, S., & Oldberg, Å. (2010) · Matrix Biology · doi:10.1016/j.matbio.2010.01.001 · Cited by 456 · see citing works

Matricellular Proteins in Cardiac Adaptation and Disease

Frangogiannis, N. G. (2012) · Physiological Reviews · doi:10.1152/physrev.00008.2011 · Cited by 440 · see citing works

Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase

Fitzgerald, M. L., Wang, Z., Park, P. W., Murphy, G., & Bernfield, M. R. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.811 · Cited by 428 · see citing works

The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses

Bellini, A., & Mattoli, S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700654 · Cited by 421 · see citing works

New insights into elastic fiber assembly

Wagenseil, J. E., & Mecham, R. P. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20111 · Cited by 421 · see citing works

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-805oc · Cited by 420 · see citing works

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

Chapman, H. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142225 · Cited by 409 · see citing works

The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.

Kuhn, C., & McDonald, J. A. (1991) · PubMed · Cited by 407 · see citing works

Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

Kim, K. K., Wei, Y., Szekeres, C. K., Kugler, M. C., Wolters, P. J., Hill, M. L., Frank, J. A., Brumwell, A. N., Wheeler, S. E., Kreidberg, J. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36940 · Cited by 399 · see citing works

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

Li, Y., Jiang, D., Liang, J., Meltzer, E. B., Gray, A., Miura, R., Wogensen, L., Yamaguchi, Y., & Noble, P. W. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102510 · Cited by 382 · see citing works

Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma

Kidd, S., Spaeth, E., Watson, K., Burks, J., Lu, H., Klopp, A., Andreeff, M., & Marini, F. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030563 · Cited by 371 · see citing works

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

Shiwen, X., Leask, A., & Abraham, D. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.01.002 · Cited by 369 · see citing works

Tenascin-X deficiency is associated with Ehlers-Danlos syndrome

Burch, G. H., Gong, Y., Liu, W., Dettman, R. W., Curry, C. J., Smith, L., Miller, W. L., & Bristow, J. (1997) · Nature Genetics · doi:10.1038/ng0997-104 · Cited by 366 · see citing works

The role of proteases in transforming growth factor-β activation

Jenkins, G. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.11.026 · Cited by 358 · see citing works

The Evolution of Extracellular Matrix

Özbek, S., Balasubramanian, P. G., Chiquet-Ehrismann, R., Tucker, R. P., & Adams, J. C. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0251 · Cited by 347 · see citing works

Fibroblasts and myofibroblasts in renal fibrosis

Meran, S., & Steadman, R. (2011) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00764.x · Cited by 345 · see citing works

New insights into form and function of fibronectin splice variants

White, E. S., Baralle, F. E., & Muro, A. F. (2008) · The Journal of Pathology · doi:10.1002/path.2388 · Cited by 323 · see citing works

α-Smooth Muscle Actin Is Crucial for Focal Adhesion Maturation in Myofibroblasts

Hinz, B., Dugina, V., Ballestrem, C., Wehrle-Haller, B., & Chaponnier, C. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-11-0729 · Cited by 322 · see citing works

Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan

Muro, A. F., Chauhan, A. K., Gajovic, S., Iaconcig, A., Porro, F., Stanta, G., & Baralle, F. E. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212079 · Cited by 319 · see citing works

Fibronectin Regulates Latent Transforming Growth Factor-β (TGFβ) by Controlling Matrix Assembly of Latent TGFβ-binding Protein-1

Dallas, S. L., Sivakumar, P., Jones, C. J. P., Chen, Q., Peters, D. M. P., Mosher, D. F., Humphries, M. J., & Kielty, C. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410762200 · Cited by 318 · see citing works

An essential role for fibronectin extra type III domain A in pulmonary fibrosis

Muro, A. F., Moretti, F. A., Moore, B. B., Yan, M., Atrasz, R. G., Wilke, C. A., Flaherty, K. R., Martinez, F. J., Tsui, J. L., Sheppard, D., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1291oc · Cited by 297 · see citing works

Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring

Mori, R., Shaw, T. J., & Martin, P. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071412 · Cited by 294 · see citing works

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans

Iozzo, R. V., & Schaefer, L. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07797.x · Cited by 292 · see citing works

Growth factor binding to the pericellular matrix and its importance in tissue engineering☆

MACRI, L., SILVERSTEIN, D., & CLARK, R. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.015 · Cited by 292 · see citing works

Heparin-II Domain of Fibronectin Is a Vascular Endothelial Growth Factor-Binding Domain: Enhancement of VEGF Biological Activity by a Singular Growth Factor/Matrix Protein Synergism

Wijelath, E., Rahman, S., Namekata, M., Murray, J., Nishimura, T., Mostafavi-Pour, Z., Patel, Y. M., Suda, Y., Humphries, M., & Sobel, M. (2006) · Circulation Research · doi:10.1161/01.res.0000246849.17887.66 · Cited by 288 · see citing works

Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease

Wang, Q., Usinger, W. R., Nichols, B., Gray, J., Xu, L., Seeley, T. W., Brenner, M., Guo, G., Zhang, W., Oliver, N., et al. (2011) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-4-4 · Cited by 279 · see citing works

The evolution of metazoan extracellular matrix

Hynes, R. O. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201109041 · Cited by 274 · see citing works

Portal fibroblasts: Underappreciated mediators of biliary fibrosis†

Dranoff, J. A., & Wells, R. G. (2010) · Hepatology · doi:10.1002/hep.23405 · Cited by 273 · see citing works

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

Gressner, O. A., & Gressner, A. M. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01826.x · Cited by 272 · see citing works

Masters and servants of the force: The role of matrix adhesions in myofibroblast force perception and transmission

Hinz, B. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.09.004 · Cited by 272 · see citing works

Fibroblast activation and myofibroblast generation in obstructive nephropathy

Grande, M. T., & López-Novoa, J. M. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.74 · Cited by 265 · see citing works

Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition

Mao, J. R., Taylor, G., Dean, W. B., Wagner, D. R., Afzal, V., Lotz, J. C., Rubin, E. M., & Bristow, J. (2002) · Nature Genetics · doi:10.1038/ng850 · Cited by 261 · cited 1× · see citing works

Extracellular matrix regulates expression of the TGF-beta 1 gene.

Streuli, C. H., Schmidhauser, C., Kobrin, M. S., Bissell, M. J., & Derynck, R. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.1.253 · Cited by 259 · see citing works

Diminished Type III Collagen Promotes Myofibroblast Differentiation and Increases Scar Deposition in Cutaneous Wound Healing

Volk, S. W., Wang, Y., Mauldin, E. A., Liechty, K. W., & ADAMS, S. L. (2011) · Cells Tissues Organs · doi:10.1159/000322399 · Cited by 257 · see citing works

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

López, B., González, A., Hermida, N., Valencia, F., de Teresa, E., & Dı́ez, J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2010 · Cited by 254 · see citing works

The role of the myofibroblast in tumor stroma remodeling

Otranto, M., Sarrazy, V., Bonté, F., Hinz, B., Gabbiani, G., & Desmoulière, A. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20377 · Cited by 253 · see citing works

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

Barker, H. E., Chang, J., Cox, T. R., Lang, G., Bird, D., Nicolau, M. M., Evans, H., Gartland, A., & Erler, J. T. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2868 · Cited by 253 · see citing works

The role of SPARC in extracellular matrix assembly

Bradshaw, A. D. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0062-6 · Cited by 252 · see citing works

Proposal for a unified CCN nomenclature: Table 1

Brigstock, D. R., Goldschmeding, R., Katsube, K.-I., Lam, S. C.-T., Lau, L. F., Lyons, K., Naus, C., Perbal, B., Riser, B., Takigawa, M., et al. (2003) · Molecular Pathology · doi:10.1136/mp.56.2.127 · Cited by 248 · see citing works

Transglutaminase 2: A molecular Swiss army knife

Gundemir, S., Colak, G., Tucholski, J., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.09.012 · Cited by 245 · see citing works

Osteopontin Expression Is Required for Myofibroblast Differentiation

Lenga, Y., Koh, A., Perera, A. S., McCulloch, C. A., Sodek, J., & Zohar, R. (2007) · Circulation Research · doi:10.1161/circresaha.107.160408 · Cited by 241 · see citing works

Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms

Sweetwyne, M. T., & Murphy-Ullrich, J. E. (2012) · Matrix Biology · doi:10.1016/j.matbio.2012.01.006 · Cited by 239 · see citing works

Emerging Concepts in the Pathogenesis of Lung Fibrosis

Hardie, W. D., Glasser, S. W., & Hagood, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081170 · Cited by 239 · see citing works

Cellular Functions of Tissue Transglutaminase

Nurminskaya, M. V., & Belkin, A. M. (2012) · International review of cytology · doi:10.1016/b978-0-12-394305-7.00001-x · Cited by 236 · see citing works

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis

Kliment, C. R., & Oury, T. D. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.036 · Cited by 233 · see citing works

Myofibroblast differentiation and survival in fibrotic disease

Kis, K., Liu, X., & Hagood, J. S. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001967 · Cited by 225 · see citing works

Fibrocytes in health and disease

Herzog, E. L., & Bucala, R. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.03.004 · Cited by 222 · see citing works

Marfan syndrome: from molecular pathogenesis to clinical treatment

Ramirez, F., & Dietz, H. C. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.04.006 · Cited by 219 · see citing works

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis

Iwaisako, K., Brenner, D. A., & Kisseleva, T. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.07002.x · Cited by 217 · see citing works

Biogenesis and function of fibrillin assemblies

Ramirez, F., & Sakai, L. Y. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0822-x · Cited by 216 · see citing works

Increased content of Type V Collagen in desmoplasia of human breast carcinoma.

Barsky, S. H., Rao, C. N., Grotendorst, G. R., & Liotta, L. A. (1982) · PubMed Central · Cited by 215 · see citing works

Glucosylation of human collagen in aging and diabetes mellitus.

Schnider, S. L., & Kohn, R. R. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109950 · Cited by 212 · see citing works

Extracellular microfibrils: contextual platforms for TGFβ and BMP signaling

Ramirez, F., & Rifkin, D. B. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.05.005 · Cited by 207 · see citing works

The fibronectin gene as a model for splicing and transcription studies

Kornblihtt, A. R., Pesce, C. G., Alonso, C. R., Cramer, P., Srebrow, A., Werbajh, S., & Muro, A. F. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.2.8641558 · Cited by 203 · see citing works

Evolution of Transglutaminase Genes: Identification of a Transglutaminase Gene Cluster on Human Chromosome 15q15

Grenard, P., Bates, M. K., & Aeschlimann, D. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102553200 · Cited by 203 · see citing works

Retinoblastoma protein family in cell cycle and cancer: A review

Paggi, M. G., Baldi, A., Bonetto, F., & Giordano, A. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199609)62:3 · Cited by 203 · see citing works

Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity

Baldock, C., Oberhauser, A. F., Ma, L., Lammie, D., Siegler, V., Mithieux, S. M., Tu, Y., Chow, J. Y. H., Suleman, F., Malfois, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014280108 · Cited by 203 · see citing works

A Polymorphism in theCTGFPromoter Region Associated with Systemic Sclerosis

Fonseca, C., Lindahl, G. E., Ponticos, M., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067655 · Cited by 201 · see citing works

Cellular and Molecular Mechanisms Regulating Fibrosis in Skeletal Muscle Repair and Disease

Serrano, A. L., Mann, C. J., Vidal, B., Ardite, E., Perdiguero, E., & Muñoz-Cánoves, P. (2011) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00007-3 · Cited by 200 · see citing works

Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury

Tamaoki, M., Imanaka‐Yoshida, K., Yokoyama, K., Nishioka, T., Inada, H., Hiroe, M., Sakakura, T., & Yoshida, T. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62954-9 · Cited by 199 · see citing works

Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation

Grotendorst, G. R., & Duncan, M. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3217com · Cited by 198 · see citing works

SPARC: a key player in the pathologies associated with obesity and diabetes

Kos, K., & Wilding, J. P. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.18 · Cited by 193 · see citing works

Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure

López, B., Querejeta, R., González, A., Larman, M., & Dı́ez, J. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.196113 · Cited by 191 · see citing works

Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition

Quaggin, S. E., & Kapùs, A. (2011) · Kidney International · doi:10.1038/ki.2011.77 · Cited by 188 · see citing works

Developmental Regulation of Elastin Production.

Swee, M., Parks, W. C., & Pierce, R. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14899 · Cited by 183 · see citing works

Mammalian transglutaminases

Esposito, C., & Caputo, I. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2004.04476.x · Cited by 182 · see citing works

Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2

Vadasz, Z., Kessler, O., Akiri, G., Gengrinovitch, S., Kagan, H. M., Baruch, Y., Izhak, O. B., & Neufeld, G. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.02.052 · Cited by 182 · see citing works

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin

Zilberberg, L., Todorovic, V., Dabovic, B., Horiguchi, M., Couroussé, T., Sakai, L. Y., & Rifkin, D. B. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24094 · Cited by 181 · see citing works

Fibronectin is required for integrin o:vβ6‐mediated activation of latent TGF‐β complexes containing LTBP‐1

Fontana, L., Chen, Y., Prijatelj, P., Sakai, T., Fässler, R., Sakai, L. Y., & Rifkin, D. B. (2005) · The FASEB Journal · doi:10.1096/fj.05-4134com · Cited by 181 · see citing works

Mesenchymal Stem Cells: Flip Side of the Coin

Mishra, P. J., Mishra, P. J., Glod, J. W., & Banerjee, D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3562 · Cited by 181 · see citing works

Advanced Glycation End-Products Induce Tubular CTGF via TGF-β–Independent Smad3 Signaling

Chung, A. C. K., Zhang, H., Kong, Y.-Z., Jia-ju, T., Huang, X. R., Kopp, J. B., & Lan, H. Y. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009010018 · Cited by 180 · see citing works

New Insights into the Regulation of Epithelial–Mesenchymal Transition and Tissue Fibrosis

Lee, K., & Nelson, C. M. (2012) · International review of cytology · doi:10.1016/b978-0-12-394305-7.00004-5 · Cited by 179 · see citing works

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling

Voloshenyuk, T. G., Landesman, E. S., Khoutorova, E., Hart, A. D., & Gardner, J. D. (2011) · Cytokine · doi:10.1016/j.cyto.2011.03.024 · Cited by 178 · see citing works

Myofibroblasts in diseased hearts: New players in cardiac arrhythmias?

Rohr, S. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.02.038 · Cited by 178 · see citing works

Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function

Sandbo, N. K., & Dulin, N. O. (2011) · Translational research · doi:10.1016/j.trsl.2011.05.004 · Cited by 178 · see citing works

Fibrosis: recent advances in myofibroblast biology and new therapeutic perspectives

Hinz, B., & Gabbiani, G. (2010) · F1000 Biology Reports · doi:10.3410/b2-78 · Cited by 172 · see citing works

Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts

Shiwen, X., Kennedy, L., Renzoni, E. A., Bou–Gharios, G., du Bois, R. M., Black, C. M., Denton, C. P., Abraham, D., & Leask, A. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23134 · Cited by 163 · see citing works

Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells

Rahman, S., Patel, Y. M., Murray, J., Patel, K., Sumathipala, R. N., Sobel, M., & Wijelath, E. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-8 · Cited by 162 · see citing works

SPARC Regulates Processing of Procollagen I and Collagen Fibrillogenesis in Dermal Fibroblasts

Rentz, T. J., Poobalarahi, F., BORNSTEIN, P. K., Sage, E. H., & Bradshaw, A. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700167200 · Cited by 160 · see citing works

EDA‐containing cellular fibronectin induces fibroblast differentiation through binding to α 4 β 7 integrin receptor and MAPK/Erk 1/2‐dependent signaling

Kohan, M., Muro, A. F., White, E. S., & Berkman, N. (2010) · The FASEB Journal · doi:10.1096/fj.10-154435 · Cited by 160 · see citing works

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

Jiang, D., Liang, J., Campanella, G. S. V., Guo, R., Yu, S., Xie, T., Liu, N., Jung, Y., Homer, R., Meltzer, E. B., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38644 · Cited by 159 · see citing works

Fibroblast migration is mediated by CD44-dependent TGFβ activation

Acharya, P. S., Majumdar, S., Jacob, M., Hayden, J., Mrass, P., Weninger, W., Assoian, R. K., & Puré, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.021683 · Cited by 157 · see citing works

Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs.

Lamme, E. N., de Vries, H. J. C., van Veen, H. A., Gabbiani, G., Westerhof, W., & Middelkoop, E. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.11.8918906 · Cited by 150 · see citing works

Extracellular matrix composition and gene expression in collagenous colitis

Aigner, T. G., Neureiter, D., Müller, S. G., et al. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70088-x · Cited by 147 · see citing works

The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation

Carracedo, S., Lü, N., Popova, S. N., Jonsson, R., Eckes, B., & Gullberg, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078766 · Cited by 145 · see citing works

Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate Immunity

Heise, R. L., Stober, V. P., Cheluvaraju, C., Hollingsworth, J. W., & Garantziotis, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.137273 · Cited by 145 · see citing works

Collagen Turnover in Normal and Degenerate Human Intervertebral Discs as Determined by the Racemization of Aspartic Acid

Sivan, S. S., Wachtel, E. J., Tsitron, E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709885200 · Cited by 144 · see citing works

Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2

Mahida, Y. R., Beltinger, J., Makh, S., Göke, M. N., Gray, T. B., Podolsky, D. K., & Hawkey, C. J. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.6.g1341 · Cited by 143 · see citing works

LTBPs, more than just an escort service

Todorović, V., & Rifkin, D. B. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23385 · Cited by 140 · see citing works

Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor

Rodrı́guez, H. M., Vaysberg, M., Mikels, A. J., McCauley, S., Velayo, A. C., García, C., & Smith, V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.094136 · Cited by 139 · see citing works

Myofibroblast-Mediated Adventitial Remodeling

Coen, M., Gabbiani, G., & Bochaton‐Piallat, M. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.231548 · Cited by 139 · see citing works

Oxidative Stress Alters Syndecan-1 Distribution in Lungs with Pulmonary Fibrosis

Kliment, C. R., Englert, J. M., Gochuico, B. R., Yu, G., Kaminski, N., Rosas, I. O., & Oury, T. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807001200 · Cited by 135 · see citing works

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

Brigstock, D. R. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0071-5 · Cited by 134 · see citing works

Modulation of TGFβ1-Dependent Myofibroblast Differentiation by Hyaluronan

Webber, J. P., Jenkins, R. L., Meran, S., Phillips, A. O., & Steadman, R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080837 · Cited by 127 · see citing works

Transforming growth factor‐β regulates the splicing pattern of fibronectin messenger RNA precursor

Borsi, L., Castellani, P., Risso, A. M., Leprini, A., & Zardi, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80664-5 · Cited by 124 · see citing works

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

Castella, L. F., Gabbiani, G., McCulloch, C. A., & Hinz, B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.033 · Cited by 123 · see citing works

Syndecan-2 Regulates Transforming Growth Factor-β Signaling

Chen, L., Klass, C. M., & Woods, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300430200 · Cited by 122 · see citing works

Osteopontin: Role in extracellular matrix deposition and myocardial remodeling post-MI

Singh, M., Foster, C. R., Dalal, S., et al. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.06.015 · Cited by 122 · see citing works

Rho‐associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

Akhmetshina, A., Dees, C., Pileckytė, M., Szűcs, G., Spriewald, B. M., Zwerina, J., Distler, O., Schett, G. A., & Distler, J. H. W. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23677 · Cited by 121 · see citing works

TG2, a novel extracellular protein with multiple functions

Wang, Z., & Griffin, M. (2011) · Amino Acids · doi:10.1007/s00726-011-1008-x · Cited by 120 · see citing works

Deficiency of tenascin‐C attenuates liver fibrosis in immune‐mediated chronic hepatitis in mice

El-Karef, A., Yoshida, T., Gabazza, E. C., Nishioka, T., Inada, H., Sakakura, T., & Imanaka‐Yoshida, K. (2006) · The Journal of Pathology · doi:10.1002/path.2099 · Cited by 120 · see citing works

Increased Expression of Type VI Collagen in Lung Fibrosis

Specks, U., Nerlich, M. L., Colby, T. V., et al. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.6.7767545 · Cited by 117 · see citing works

Distribution of proteoglycans antigenically related to corneal keratan sulfate proteoglycan.

Funderburgh, J. L., Caterson, B., & Conrad, G. W. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60856-7 · Cited by 116 · see citing works

Perturbation of transforming growth factor (TGF)-ß1 association with latent TGF-β binding protein yields inflammation and tumors

Yoshinaga, K., Obata, H., Jurukovski, V., Mazzieri, R., Chen, Y., Zilberberg, L., Huso, D. L., Melamed, J., Prijatelj, P., Todorović, V., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805411105 · Cited by 113 · see citing works

Cardiac extracellular matrix remodeling: Fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC)

McCurdy, S. M., Baicu, C. F., Heymans, S. R. B., & Bradshaw, A. D. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.06.018 · Cited by 112 · see citing works

α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy

Talior‐Volodarsky, I., Connelly, K. A., Arora, P. D., Gullberg, D., & McCulloch, C. A. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs259 · Cited by 110 · see citing works

Lysyl Oxidase: Mechanism, Regulation and Relationship to Liver Fibrosis

Kagan, H. M. (1994) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80995-7 · Cited by 108 · see citing works

Fibrogenic Reactions in Lung Disease

Araya, J., & Nishimura, S. L. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092217 · Cited by 108 · see citing works

Cross-linked open-pore elastic hydrogels based on tropoelastin, elastin and high pressure CO2

Annabi, N., Mithieux, S. M., Weiss, A. S., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.051 · Cited by 107 · see citing works

Transglutaminase inhibition ameliorates experimental diabetic nephropathy

Huang, L., Haylor, J., Hau, Z., et al. (2009) · Kidney International · doi:10.1038/ki.2009.230 · Cited by 107 · see citing works

Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor

Colston, J. T., de la Rosa, S. D., Koehler, M., Gonzales, K., Mestril, R., Freeman, G. L., Bailey, S. R., & Chandrasekar, B. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00428.2007 · Cited by 107 · see citing works

Syndecan-4 Prevents Cardiac Rupture and Dysfunction After Myocardial Infarction

Matsui, Y., Ikesue, M., Danzaki, K., Morimoto, J. O., Sato, M., Tanaka, S., Kojima, T., Tsutsui, H., & Uede, T. (2011) · Circulation Research · doi:10.1161/circresaha.110.235689 · Cited by 107 · see citing works

Future treatments in systemic sclerosis

Asano, Y. (2010) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2009.00758.x · Cited by 103 · see citing works

Tenascin-C deficiency attenuates TGF-β-mediated fibrosis following murine lung injury

Carey, W. A., Taylor, G. D., Dean, W. B., & Bristow, J. D. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00385.2009 · Cited by 102 · see citing works

Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos.

Chang, L. Y., Overby, L. H., Brody, A. R., & Crapo, J. D. (1988) · PubMed Central · Cited by 101 · see citing works

Potential Role for Heparan Sulfate Proteoglycans in Regulation of Transforming Growth Factor-β (TGF-β) by Modulating Assembly of Latent TGF-β-binding Protein-1

Chen, Q., Sivakumar, P., Barley, C., Peters, D. M. P., Gomes, R. R., Farach‐Carson, M. C., & Dallas, S. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703341200 · Cited by 101 · see citing works

Molecular and Cellular Mechanisms of Syndecans in Tissue Injury and Inflammation

Bartlett, A. H., Hayashida, K., & Park, P. W. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)07324-7 · Cited by 100 · see citing works

Elastin-like protein matrix reinforced with collagen microfibers for soft tissue repair

Caves, J. M., Cui, W., Wen, J., Kumar, V. A., Haller, C. A., & Chaikof, E. L. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.009 · Cited by 97 · see citing works

Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis

Kagan, H. M. (2000) · Acta Tropica · doi:10.1016/s0001-706x(00)00128-5 · Cited by 97 · see citing works

Age-Related Changes in Pericellular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast Differentiation

Simpson, R., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R., & Phillips, A. O. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090045 · Cited by 93 · see citing works

Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre‐disposition pending between fiction and reality

Gressner, O. A., Weiskirchen, R., & Gressner, A. M. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00092.x · Cited by 93 · see citing works

Hyaluronan Stabilizes Focal Adhesions, Filopodia, and the Proliferative Phenotype in Esophageal Squamous Carcinoma Cells

Twarock, S., Tammi, M., Savani, R. C., & Fischer, J. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093146 · Cited by 92 · see citing works

Lysyl Oxidase-Like and Lysyl Oxidase Are Present in the Dermis and Epidermis of a Skin Equivalent and in Human Skin and Are Associated to Elastic Fibers

Noblesse, E., Cenizo, V., Bouez, C., Borel, A., Gleyzal, C., Peyrol, S., Jacob, M.-P., Sommer, P., & Damour, O. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22330.x · Cited by 92 · see citing works

Appearance of the Myofibroblastic Phenotype in Dupuytren’s Disease Is Associated with a Fibronectin, Laminin, Collagen Type IV and Tenascin Extracellular Matrix

Berndt, A., Kosmehl, H., Katenkamp, D., et al. (2008) · Pathobiology · doi:10.1159/000163879 · Cited by 90 · see citing works

Myofibroblastic stromal reaction in carcinoma of the breast: variations of collagenous matrix and structural glycoproteins

Lagac�, R., Grimaud, J.-A., Sch�rch, W., et al. (1985) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00739962 · Cited by 89 · see citing works

Modulation of α‐smooth muscle actin expression in fibroblasts by transforming growth factor‐β isoforms: an in vivo and in vitro study

Serini, G., & Gabbiani, G. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40217.x · Cited by 87 · see citing works

Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis

Sabatelli, P., Gualandi, F., Gara, S. K., Grumati, P., Zamparelli, A., Martoni, E., Pellegrini, C., Merlini, L., Ferlini, A., Bonaldo, P., et al. (2011) · Matrix Biology · doi:10.1016/j.matbio.2011.12.003 · Cited by 84 · see citing works

SPARC mediates early extracellular matrix remodeling following myocardial infarction

McCurdy, S. M., Dai, Q., Zhang, J., Zamilpa, R., Ramirez, T. A., Dayah, T. J., Nguyen, N., Jin, Y.-F., Bradshaw, A. D., & Lindsey, M. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01070.2010 · Cited by 84 · see citing works

Fibronectin Binds and Enhances the Activity of Bone Morphogenetic Protein 1

Huang, G., Zhang, Y., Kim, B., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024125 · Cited by 83 · see citing works

Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts

Tokudome, T., Horio, T., Yoshihara, F., Suga, S., Kawano, Y., Kohno, M., & Kangawa, K. (2004) · Metabolism · doi:10.1016/j.metabol.2004.01.006 · Cited by 81 · see citing works

Cardiac Fibroblasts in Cell Culture Systems: Myofibroblasts All Along?

Rohr, S. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182137e17 · Cited by 81 · see citing works

Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair

Iredale, J. P. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.011 · Cited by 80 · see citing works

High glucose promotes the production of collagen types I and III by cardiac fibroblasts through a pathway dependent on extracellular-signal-regulated kinase 1/2

Tang, M., Zhang, W. J., Lin, H., Jiang, H., Dai, H., & Zhang, Y. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9401-6 · Cited by 79 · see citing works

The cytoskeleton and extracellular matrix of the Dupuytren's disease “myofibroblast”: An immunofluorescence study of a nonmuscle cell type

Tomasek, J. J., Schultz, R. J., Episalla, C. W., & Newman, S. A. (1986) · The Journal Of Hand Surgery · doi:10.1016/s0363-5023(86)80143-5 · Cited by 79 · see citing works

Hyaluronan Attenuates Transforming Growth Factor-β1-Mediated Signaling in Renal Proximal Tubular Epithelial Cells

Ito, T., Williams, J. D., Fraser, D. J., & Phillips, A. O. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63758-3 · Cited by 79 · see citing works

Type V Collagen Modulates Alloantigen-Induced Pathology and Immunology in the Lung

Mares, D. C., Heidler, K. M., Smith, G. N., et al. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.1.3924 · Cited by 77 · see citing works

SPARC regulates collagen interaction with cardiac fibroblast cell surfaces

Harris, B. S., Zhang, Y., Card, L., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01247.2010 · Cited by 75 · see citing works

CTGF and chronic kidney fibrosis

Pollock, C. A. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s13 · Cited by 75 · see citing works

Small leucine‐rich proteoglycans, decorin and fibromodulin, are reduced in postburn hypertrophic scar

Honardoust, D., Varkey, M., Hori, K., Ding, J., Shankowsky, H. A., & Tredget, E. E. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2011.00677.x · Cited by 74 · see citing works

Into the matrix

Sivakumar, P., Ntolios, P., Jenkins, G. R., & Laurent, G. J. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328356800f · Cited by 66 · see citing works

The molecular mediators of type 2 epithelial to mesenchymal transition (EMT) and their role in renal pathophysiology

Burns, W. C., & Thomas, M. C. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001481 · Cited by 66 · see citing works

Deficiency of Biglycan Causes Cardiac Fibroblasts to Differentiate into a Myofibroblast Phenotype

Melchior‐Becker, A., Dai, G., Ding, Z., Schaefer, L., Schrader, J., Young, M. F., & Fischer, J. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192682 · Cited by 65 · see citing works

PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation

Smith, E. M., Mitsi, M., Nugent, M. A., & Symes, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902510106 · Cited by 63 · see citing works

Wound Healing in Tenascin-X Deficient Mice Suggests that Tenascin-X is Involved in Matrix Maturation Rather than Matrix Deposition

Egging, D. F., van Vlijmen‐Willems, I. M. J. J., van Tongeren, T., Schalkwijk, J., & Peeters, A. C. T. M. (2007) · Connective Tissue Research · doi:10.1080/03008200601166160 · Cited by 63 · see citing works

The role of fibrocytes in fibrotic diseases of the lungs and heart

Keeley, E. C., Mehrad, B., & Strieter, R. M. (2011) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-4-2 · Cited by 62 · see citing works

Increased expression of lysyl oxidase in skin with scleroderma

Chanoki, M., Ishii, M., Kobayashi, H., Fushida, H., Yashiro, N., Hamada, T., & Ooshima, A. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb02743.x · Cited by 62 · see citing works

Molecular biology and pathology of human elastin

Uitto, J., Christiano, A. M., Kähäri, V., et al. (1991) · Biochemical Society Transactions · doi:10.1042/bst0190824 · Cited by 62 · see citing works

Extracellular microfibrils are increased in localized and systemic scleroderma skin.

Fleischmajer, R., Jacobs, L., Schwartz, E., et al. (1991) · PubMed · Cited by 61 · see citing works

Force-induced Myofibroblast Differentiation through Collagen Receptors Is Dependent on Mammalian Diaphanous (mDia)

Chan, M. W. C., Chaudary, F., Lee, W., Copeland, J. W. R., & McCulloch, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075218 · Cited by 60 · see citing works

Collagen lysyl oxidase activity in the lung increases during bleomycin-induced lung fibrosis.

Counts, D. F., Evans, J. N. G., DiPetrillo, T. A., et al. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32860-0 · Cited by 59 · see citing works

Lysyl Oxidase Expression and Collagen Cross-Linking during Chronic Adriamycin Nephropathy

Donato, A. D., Ghiggeri, G. M., Duca, M. D., et al. (2008) · ˜The œNephron journals/Nephron journals · doi:10.1159/000190168 · Cited by 57 · see citing works

Regulation of Elastin Gene Expressiona

Rosenbloom, J., Rosenbloom, J., Bashir, M. M., et al. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb17012.x · Cited by 56 · see citing works

Matrix control of scarring

Yates, C., Bodnar, R., & Wells, A. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0663-0 · Cited by 55 · see citing works

Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468 · see citing works

Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials

Lampi, M. C., & Reinhart-King, C. A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0475 · Cited by 551 · see citing works

Myofibroblasts

Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424 · see citing works

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works

The role of myofibroblasts in wound healing

Hinz, B. (2016) · Current Research in Translational Medicine · doi:10.1016/j.retram.2016.09.003 · Cited by 328 · see citing works

The myofibroblast at a glance

Pakshir, P., Noskovicova, N., Lodyga, M., Son, D. O., Schuster, R., Goodwin, A., Karvonen, H., & Hinz, B. (2020) · Journal of Cell Science · doi:10.1242/jcs.227900 · Cited by 293 · see citing works

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention

Van De Water, L., Varney, S., & Tomasek, J. J. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0393 · Cited by 251 · see citing works

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Hinz, B., McCulloch, C. A., & Coelho, N. M. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.027 · Cited by 182 · see citing works

Principles of Cell Circuits for Tissue Repair and Fibrosis

Adler, M., Mayo, A., Zhou, X., Franklin, R. A., Meizlish, M. L., Medzhitov, R., Kallenberger, S. M., & Alon, U. (2020) · iScience · doi:10.1016/j.isci.2020.100841 · Cited by 177 · see citing works

The role of mouse strain differences in the susceptibility to fibrosis: a systematic review

Walkin, L., Herrick, S. E., Summers, A., Brenchley, P. E., Hoff, C. M., Korstanje, R., & Margetts, P. J. (2013) · Fibrogenesis &amp; Tissue Repair · doi:10.1186/1755-1536-6-18 · Cited by 160 · see citing works

Unraveling SSc Pathophysiology; The Myofibroblast

van Caam, A., Vonk, M., van den Hoogen, F., van Lent, P., & van der Kraan, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02452 · Cited by 153 · see citing works

Fibrous scaffolds for building hearts and heart parts

Capulli, A. K., MacQueen, L. A., Sheehy, S. P., & Parker, K. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.020 · Cited by 130 · see citing works

Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment

Yang, X., Li, Q., Liu, W., Zong, C., Wei, L., Shi, Y., & Han, Z. (2023) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-023-00983-5 · Cited by 120 · see citing works

Macrophages and the Regulation of Adipose Tissue Remodeling

Martinez-Santibañez, G., & Nien-Kai Lumeng, C. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161113 · Cited by 111 · see citing works

Fascia Mobility, Proprioception, and Myofascial Pain.

Langevin, H. M. (2021) · Life · doi:10.3390/life11070668 · Cited by 97 · see citing works

Identification of a myofibroblast-specific expression signature in skin wounds

Bergmeier, V., Etich, J., Pitzler, L., Frie, C., Koch, M., Fischer, M., Rappl, G., Abken, H., Tomasek, J. J., & Brachvogel, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.07.005 · Cited by 87 · see citing works

Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Reaction to the Immune Response of Implanted Biomaterials

Anderson, J. M., & Jiang, S. (2017) · The Immune Response to Implanted Materials and Devices · doi:10.1007/978-3-319-45433-7_2 · Cited by 55 · see citing works

Inhibition of NF-κB by ACT001 reduces fibroblast activity in idiopathic pulmonary fibrosis

Jaffar, J., Glaspole, I., Symons, K., & Westall, G. (2021) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2021.111471 · Cited by 45 · see citing works

Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases

Pellegata, N. S., Berriel Diaz, M., Rohm, M., & Herzig, S. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10058-y · Cited by 33 · see citing works

Myofibroblast progeny in wound biology and wound healing studies

Monika, P., Waiker, P. V., Chandraprabha, M. N., Rangarajan, A., & Murthy, K. N. C. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12937 · Cited by 88 · see citing works

Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts

Cho, N., Razipour, S., & McCain, M. L. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218761628 · Cited by 71 · see citing works

Regeneration and growth control in Nereis: III. Separation of wound healing and segment regeneration by experimental endocrine manipulation

Golding, D. W. (1974) · Development · doi:10.1242/dev.32.1.99 · Cited by 10 · see citing works

Role of Matrix Proteins in Balancing Tissue Stiffness and Inflammation in Fibrosis

Varghese, S. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2017.11.171

Circuit to target approach defines an autocrine myofibroblast loop that drives cardiac fibrosis

(2023) · doi:10.1101/2023.01.01.522422 · Cited by 6 · see citing works