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New insights into elastic fiber assembly

Wagenseil, Jessica E., Mecham, Robert P.·2007·Birth Defects Research Part C: Embryo Today: Reviews

DOI 10.1002/bdrc.20111

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Abstract

Elastic fibers provide recoil to tissues that undergo repeated stretch, such as the large arteries and lung. These large extracellular matrix (ECM) structures contain numerous components, and our understanding of elastic fiber assembly is changing as we learn more about the various molecules associated with the assembly process. The main components of elastic fibers are elastin and microfibrils. Elastin makes up the bulk of the mature fiber and is encoded by a single gene. Microfibrils consist mainly of fibrillin, but also contain or associate with proteins such as microfibril associated glycoproteins (MAGPs), fibulins, and EMILIN‐1. Microfibrils were thought to facilitate alignment of elastin monomers prior to cross‐linking by lysyl oxidase (LOX). We now know that their role, as well as the overall assembly process, is more complex. Elastic fiber formation involves elaborate spatial and temporal regulation of all of the involved proteins and is difficult to recapitulate in adult tissues. This report summarizes the known interactions between elastin and the microfibrillar proteins and their role in elastic fiber assembly based on in vitro studies and evidence from knockout mice. We also propose a model of elastic fiber assembly based on the current data that incorporates interactions between elastin, LOXs, fibulins and the microfibril, as well as the pivotal role played by cells in structuring the final functional fiber. Birth Defects Research (Part C) 81:229–240, 2007. © 2008 Wiley‐Liss, Inc.

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Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema
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Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues
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Functional Rescue of Elastin Insufficiency in Mice by the Human Elastin Gene: Implications for Mouse Models of Human Disease
Hirano, E., Knutsen, R. H., Sugitani, H., Ciliberto, C. H., & Mecham, R. P. (2007) · Circulation Research · doi:10.1161/circresaha.107.153510 · Cited by 101
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Elastic fiber macro‐assembly is a hierarchical, cell motion‐mediated process
Czirók, A., Tárnoki-Zách, J., Kozel, B. A., Mecham, R. P., Davis, E. C., & Rongish, B. J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20573 · Cited by 93
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Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa
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Hydrophobic Domains of Human Tropoelastin Interact in a Context-dependent Manner
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Fibrillin-1 and −2 contain heparin-binding sites important for matrix deposition and that support cell attachment
Ritty, T. M., Broekelmann, T. J., WERNECK, C. C., & Mecham, R. P. (2003) · Biochemical Journal · doi:10.1042/bj20030649 · Cited by 88
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Matrix loading: Assembly of extracellular matrix collagen fibrils during embryogenesis
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Microfibril-associated Glycoprotein-2 Interacts with Fibrillin-1 and Fibrillin-2 Suggesting a Role for MAGP-2 in Elastic Fiber Assembly
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Mutation of the gene encoding fibrillin-2 results in syndactyly in mice
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Elastin cross-linking in vitro. Studies on factors influencing the formation of desmosines by lysyl oxidase action on tropoelastin
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MAGP-2 Has Multiple Binding Regions on Fibrillins and Has Covalent Periodic Association with Fibrillin-containing Microfibrils
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Extracellular matrix structure
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Extracellular Matrix Assembly: A Multiscale Deconstruction
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Assembly of Fibronectin Extracellular Matrix
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The myofibroblast matrix: implications for tissue repair and fibrosis
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See all 420

Authors: Wagenseil, J. E., & Mecham, R. P.
Venue: Birth Defects Research Part C: Embryo Today: Reviews
Publisher: Wiley
Published: 2007-12
Volume: 81
Issue: 4
Pages: 229-240
ISSN: 1542-975X (ISSN-L)
1542-9768
DOI: 10.1002/bdrc.20111
OpenAlex: W2146275594
Cited by: 420
References: 100
FWCI: 12.39
Type: journal article
Language: en
Open access: closed

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New insights into elastic fiber assembly

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