Cited by 119Sperm and Testicular FunctionGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

Histone crotonylation specifically marks the haploid male germ cell gene expression program: Post‐meiotic male‐specific gene expression

Montellier, Emilie, Rousseaux, Sophie, Zhao, Yingming, Khochbin, Saadi·2012·BioEssays

Abstract

The haploid male germ cell differentiation program controls essential steps of male gametogenesis and relies partly on a significant number of sex chromosome‐linked genes. These genes need to escape chromosome‐wide transcriptional repression of sex chromosomes, which occurs during meiosis and is largely maintained in post‐meiotic cells. A newly discovered histone lysine modification, crotonylation (Kcr), marks X/Y‐linked genes that are active in post‐meiotic male germ cells. Histone Kcr, by conferring resistance to transcriptional repressors, could be a dominant element in maintaining these genes active in the globally repressive environment of haploid cell sex chromosomes. Furthermore, the same mark was found associated with post‐meiotically activated genes on autosomes. Histone Kcr therefore appears to be an indicator of the male haploid cell gene expression program and a notable element of genome programming in the post‐meiotic phases of spermatogenesis.

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Crossref · 10.1002/bies.201100141

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Authors
Montellier, E., Rousseaux, S., Zhao, Y., & Khochbin, S.
Affiliations
  • Inserm (FR)
  • Chinese Academy of Sciences (CN)
Corresponding author
Khochbin, Saadi
Venue
BioEssays
Publisher
Wiley
Published
2011-12-15
Volume
34
Issue
3
Pages
187-193
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2107882638
Cited by
116
References
46
Citations by year
2026: 1 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 5 · 2018: 11 · 2017: 7 · 2016: 14 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 5
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • BioEssays (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agence Nationale de la Recherche
  • Institut National Du Cancer
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
histone crotonylation, male germ cells, haploid cells, sex chromosome inactivation, spermatogenesis, autosomal genes, transcriptional repression
MeSH terms
Animals, Haploidy, Histone Deacetylases, Histones, Male, Mammals, Meiosis, Sex Chromosomes, Spermatocytes, Spermatogenesis, Testis, Transcriptional Activation, Gene Expression, Chromatin Assembly and Disassembly, Genes, X-Linked, Genes, Y-Linked

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