Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
Abstract
In higher eukaryotes, histone methylation is involved in maintaining cellular identity during somatic development. As most nucleosomes are replaced by protamines during spermatogenesis, it is unclear whether histone modifications function in paternal transmission of epigenetic information. Here we show that two modifications important for Trithorax- and Polycomb-mediated gene regulation have methylation-specific distributions at regulatory regions in human spermatozoa. Histone H3 Lys4 dimethylation (H3K4me2) marks genes that are relevant in spermatogenesis and cellular homeostasis. In contrast, histone H3 Lys27 trimethylation (H3K27me3) marks developmental regulators in sperm, as in somatic cells. However, nucleosomes are only moderately retained at regulatory regions in human sperm. Nonetheless, genes with extensive H3K27me3 coverage around transcriptional start sites in particular tend not to be expressed during male and female gametogenesis or in preimplantation embryos. Promoters of orthologous genes are similarly modified in mouse spermatozoa. These data are compatible with a role for Polycomb in repressing somatic determinants across generations, potentially in a variegating manner.
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Given the role of histone methylation in establishing active promoters, it appears likely that dysregulation of histone methylation may have downstream effects with the potential to disrupt neurodevelopment and coordinated gene expression, as animal studies have demonstrated.
“Given the role of this process in establishing active promoters38, it appears likely that the dysregulation of histone methylation may have downstream effects with the potential to disrupt neurodevelopment and coordinated gene expression, as animal studies have demonstrated39.”
From Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways (2015) · cites this paper as [38]
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- Authors
- Brykczynska, U., Hisano, M., Erkek, S., Ramos, L., Oakeley, E. J., Roloff, T. C., Beisel, C., Schübeler, D., Stadler, M. B., & Peters, A. H. F. M.
- Affiliations
- Friedrich Miescher Institute (CH)
- Radboud University Nijmegen (NL)
- University of Geneva (CH)
- ETH Zurich (CH)
- Corresponding author
- Peters, Antoine H F M
- ORCID
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-05-16
- Volume
- 17
- Issue
- 6
- Pages
- 679-687
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2103410123
- Cited by
- 680
- References
- 60
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 24 · 2023: 41 · 2022: 38 · 2021: 38 · 2020: 36 · 2019: 43 · 2018: 50 · 2017: 57 · 2016: 42 · 2015: 58 · 2014: 68 · 2013: 46 · 2012: 46
- FWCI
- 18.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Novartis Foundation
- Boehringer Ingelheim Fonds
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Krebsliga Schweiz
- Swiss Cancer Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- histone methylation, spermatozoa, Polycomb group proteins, Trithorax group proteins, H3K27me3, H3K4me2, protamine, spermatogenesis, epigenetic inheritance, paternal transmission, transcriptional repression, promoter, developmental regulators, preimplantation embryo, species conservation
- MeSH terms
- Animals, Binding Sites, Female, Histones, Humans, Male, Methylation, Nucleosomes, Promoter Regions, Genetic, Protein Binding, Histone-Lysine N-Methyltransferase, Repressor Proteins, Species Specificity, Spermatogenesis, Spermatozoa, Transcription, Genetic, Signal Transduction, Evolution, Molecular, DNA Methylation, Mice, Myeloid-Lymphoid Leukemia Protein, Polycomb-Group Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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