The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays
Open accessAbstract
Microscale techniques have been applied to biological assays for nearly two decades, but haven't been widely integrated as common tools in biological laboratories. The significant differences between several physical phenomena at the microscale versus the macroscale have been exploited to provide a variety of new types of assays (such as gradient production or spatial cell patterning). However, the use of these devices by biologists seems to be limited by issues regarding biological validation, ease of use, and the limited available readouts for assays done using microtechnology. Critical validation work has been done recently that highlights the current challenges for microfluidic methods and suggest ways in which future devices might be improved to better integrate with biological assays. With more validation and improved designs, microscale techniques hold immense promise as a platform to study aspects of cell biology that are not possible using current macroscale techniques. BioEssays 30:811–821, 2008. © 2008 Wiley Periodicals, Inc.
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Purcell, E. M. (1977) · American Journal of Physics · doi:10.1119/1.10903 · Cited by 4,360
Biomolecular gradients in cell culture systems
Keenan, T. M., & Folch, A. (2008) · Lab Chip · doi:10.1039/b711887b · Cited by 596
Berthier, E., Warrick, J., Yu, H., & Beebe, D. J. (2008) · Lab on a Chip · doi:10.1039/b717422e · Cited by 114
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Cited by
The present and future role of microfluidics in biomedical research
Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995
Self-citationAdvantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
Halldorsson, S., Lucumi, E., Gómez-Sjöberg, R., & Fleming, R. M. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.029 · Cited by 1,027
Engineers are from PDMS-land, Biologists are from Polystyrenia
Berthier, E., Young, E. W. K., & Beebe, D. (2012) · Lab on a Chip · doi:10.1039/c2lc20982a · Cited by 799
Self-citationBiological implications of polydimethylsiloxane-based microfluidic cell culture
Regehr, K. J., Domenech, M., Koepsel, J. T., Carver, K. C., Ellison-Zelski, S. J., Murphy, W. L., Schuler, L. A., Alarid, E. T., & Beebe, D. J. (2009) · Lab on a Chip · doi:10.1039/b903043c · Cited by 719
Self-citationFundamentals of microfluidic cell culture in controlled microenvironments
Young, E. W. K., & Beebe, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b909900j · Cited by 615
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Metadata
- Authors
- Paguirigan, A. L., & Beebe, D. J.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2008-08-08
- Volume
- 30
- Issue
- 9
- Pages
- 811-821
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2056937003
- Cited by
- 208
- References
- 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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