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Retinoic acid and development of the central nervous system
Abstract
We consider the evidence that RA†, the vitamin A metabolite, is involved in three fundamental aspects of the development of the CNS: (1) the stimulation of axon outgrowth in particular neuronal sub‐types; (2) the migration of the neural crest; and (3) the specification of rostrocaudal position in the developing CNS (forebrain, midbrain, hindbrain, spinal cord). The evidence we discuss involves RA‐induction of neurites in cell cultures and explants of neural tissue; the teratological effects of RA on the embryo's nervous system; the observation that RA can be detected endogenously in the spinal cord; and the fact that the receptors and binding proteins for RA are expressed in precise domains and neuronal cell types within the nervous system.
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Citations
Cited by
Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase
White, J. A., Guo, Y.-D., Baetz, K., Beckett-Jones, B., Bonasoro, J., Hsu, K. E., Dilworth, F. J., Jones, G., & Petkovich, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29922 · Cited by 382
Zhao, D., McCaffery, P., Ivins, K. J., Neve, R. L., Hogan, P., Chin, W. W., & Dräger, U. C. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0015h.x · Cited by 344
From embryonal carcinoma cells to neurons: The P19 pathway
Bain, G., Ray, W. J., Yao, M., & Gottlieb, D. I. (1994) · BioEssays · doi:10.1002/bies.950160509 · Cited by 240
PARALOGOUS HOX GENES: Function and Regulation
Maconochie, M., Nonchev, S., Morrison, A., & Krumlauf, R. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.529 · Cited by 220
Global gene expression patterns during neural differentiation of P19 embryonic carcinoma cells
Wei, Y., Harris, T., & Childs, G. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700409.x · Cited by 47
Metadata
- Authors
- Maden, M., & Holder, N.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1992-07
- Volume
- 14
- Issue
- 7
- Pages
- 431-438
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2133760066
- Cited by
- 162
- References
- 0
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
