The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Molecular Identification of a Major Retinoic‐Acid‐Synthesizing Enzyme, a Retinaldehyde‐Specific Dehydrogenase
Abstract
Retinoic acid, a developmental signal implicated in the formation of the neural axis, is present at high levels in the early embryonic trunk region, where it is synthesized by a novel dehydrogenase. Here we show that the same enzyme is inducible by retinoic acid in P19 teratocarcinoma cells, and we report the cloning from P19 cells of a cDNA encoding a novel dehydrogenase, named retinaldehyde dehydrogenase‐2 (RALDH‐2). Expression in COS cells shows RALDH‐2 to be highly effective in oxidation of retinaldehyde, with no detectable activity on any other aldehyde tested.In situ hybridization histochemistry on the embryonic trunk reveales RALDH‐2 mRNA both in mesoderm and neuroectoderm, with highest neuroectodermal expression in the ventral horn of the spinal cord at two restricted locations along the anteroposterior axis, presumably the subpopulation of motoneurons that innervate the limbs.
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Cites
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
Kozak, M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.2.857 · Cited by 3,293
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,307
The induction of differentiation in teratocarcinoma stem cells by retinoic acid
Strickland, S., & Mahdavi, V. (1978) · Cell · doi:10.1016/0092-8674(78)90008-9 · Cited by 1,420
Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene
de The, H., del Mar Vivanco-Ruiz, M., Tiollais, P., Stunnenberg, H., & Dejean, A. (1990) · Nature · doi:10.1038/343177a0 · Cited by 1,006
The Retinoids-Biology, Chemistry and Medicine
Wolf, G. (1994) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.796a · Cited by 998
Identification and spatial distribution of retinoids in the developing chick limb bud
Thaller, C., & Eichele, G. (1987) · Nature · doi:10.1038/327625a0 · Cited by 953
Retinoic acid causes an anteroposterior transformation in the developing central nervous system
Durston, A. J., Timmermans, J. P. M., Hage, W. J., Hendriks, H. F. J., de Vries, N. J., Heideveld, M., & Nieuwkoop, P. D. (1989) · Nature · doi:10.1038/340140a0 · Cited by 887
Retinoids and their receptors in differentiation, embryogenesis, and neoplasia
De Luca, L. M. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.14.1661245 · Cited by 843
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Allenby, G., Bocquel, M. T., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A., Kastner, P., Grippo, J. F., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.30 · Cited by 754
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Cited by
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,077
Retinoic acid in the development, regeneration and maintenance of the nervous system
Maden, M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2212 · Cited by 896
Retinoids in Embryonal Development
Ross, S. A., McCaffery, P. J., Drager, U. C., & De Luca, L. M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1021 · Cited by 866
Self-citationDuester, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01497.x · Cited by 570
Metadata
- Authors
- Zhao, D., McCaffery, P., Ivins, K. J., Neve, R. L., Hogan, P., Chin, W. W., & Dräger, U. C.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1996-08
- Volume
- 240
- Issue
- 1
- Pages
- 15-22
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2041710680
- Cited by
- 344
- References
- 52
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Molecular Identification of a Major Retinoic‐Acid‐Synthesizing Enzyme, a Retinaldehyde‐Specific Dehydrogenase. https://app.cochat.ai/papers/10.1111/j.1432-1033.1996.0015h.x
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- Zhao, D., McCaffery, P., Ivins, K. J., Neve, R. L., Hogan, P., Chin, W. W., & Dräger, U. C. (1996). Molecular Identification of a Major Retinoic‐Acid‐Synthesizing Enzyme, a Retinaldehyde‐Specific Dehydrogenase. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1996.0015h.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
