The DOI matches its Crossref record.
Mucins: Structure, function, and associations with malignancy
Abstract
Mucins are a family of high molecular weight, highly glycosylated glycoproteins found in the apical cell membrane of human epithelial cells from the mammary gland, salivary gland, digestive tract, respiratory tract, kidney, bladder, prostate, uterus and rete testis. Increased synthesis of the core protein and alterations in the carbohydrates attached to these glycoproteins are believed to play important roles in the function and proliferation of tumour cells. Aberrant glycosylation leads not only to the production of novel carbohydrate structures, but also to the exposure of the core peptide. These novel epitopes may be candidates for diagnosis or therapy, by using either synthetic mucin fragments as vaccines, or monoclonal antibody‐based reagents which detect these structures.
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Citations
Cited by
Bobek, L. A., Tsai, H., Biesbrock, A. R., & Levine, M. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80762-5 · Cited by 458
Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy
Springer, G. F. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050144 · Cited by 426
Mucin gene structure and expression: protection vs. adhesion
Van Klinken, B. J., Dekker, J., Buller, H. A., & Einerhand, A. W. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.5.g613 · Cited by 319
Andrianifahanana, M., Moniaux, N., & Batra, S. K. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.01.002 · Cited by 314
Kaplan, G., Totsuka, A., Thompson, P., Akatsuka, T., Moritsugu, Y., & Feinstone, S. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00803.x · Cited by 286
An intestinal mucin is the target substrate for a baculovirus enhancin
Wang, P., & Granados, R. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6977 · Cited by 274
Expression of MUC2‐mucin in colorectal adenomas and carcinomas of different histological types
Blank, M., Klussmann, E., Krüger‐Krasagakes, S., Schmitt‐Gräff, A., Stolte, M., Bornhoeft, G., Stein, H., Xing, P., McKenzie, I. F. C., Verstijnen, C. P. H. J., et al. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590302 · Cited by 132
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Metadata
- Authors
- Devine, P. L., & McKenzie, I. F. C.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1992-09
- Volume
- 14
- Issue
- 9
- Pages
- 619-625
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2083574178
- Cited by
- 247
- References
- 0
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
