Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

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<i>Helicobacter pylori</i> cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

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Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

Yalcin, S., Zhang, X., Luciano, J. P., Mungamuri, S. K., Marinkovic, D., Vercherat, C., Sarkar, A., Grisotto, M., Taneja, R., & Ghaffari, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800517200 · Cited by 247 · see citing works

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

Hiller, B., Achleitner, M., Glage, S., Naumann, R., Behrendt, R., & Roers, A. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120876 · Cited by 245 · see citing works

p21/CDKN1A Mediates Negative Regulation of Transcription by p53

Löhr, K., Möritz, C., Contente, A., & Dobbelstein, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212517200 · Cited by 227 · see citing works

p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint

Smits, V. A. J., Klompmaker, R., Vallenius, T., Rijksen, G., Mäkelä, T. P., & Medema, R. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005437200 · Cited by 221 · see citing works

Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

Wei, W., Hemmer, R. M., & Sedivy, J. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6748-6757.2001 · Cited by 217 · see citing works

Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit

Gera, N., Yang, A., Holtzman, T. S., Lee, S. X., Wong, E. T., & Swanson, K. D. (2015) · PLOS ONE · doi:10.1371/journal.pone.0125269 · Cited by 217 · see citing works

p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress

Charrier-Savournin, F. B., Château, M.-T., Gire, V., Sedivy, J., Piette, J., & Dulić, V. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0871 · Cited by 202 · see citing works

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

Liu, G., & Chen, X. (2002) · Oncogene · doi:10.1038/sj.onc.1205862 · Cited by 207 · see citing works

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

Jin, Y., Lee, H., Zeng, S. X., Dai, M., & Lu, H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg600 · Cited by 206 · see citing works

miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

Xiao, J., Lin, H., Luo, X., Luo, X., & Wang, Z. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.347 · Cited by 189 · see citing works

Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells

Weinstein, D., Simon, M., Yehezkel, E., Laron, Z., & Werner, H. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.912 · Cited by 179 · see citing works

p53 Regulation of G ₂ Checkpoint Is Retinoblastoma Protein Dependent

Flatt, P. M., Tang, L. J., Scatena, C. D., Szak, S. T., & Pietenpol, J. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4210-4223.2000 · Cited by 161 · see citing works

Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts

Dulić, V., Beney, G.-E., Frebourg, G., Drullinger, L. F., & Stein, G. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6741-6754.2000 · Cited by 149 · see citing works

The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells

Jallepalli, P. V., Lengauer, C., Vogelstein, B., & Bunz, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213159200 · Cited by 154 · see citing works

p53 accumulates but is functionally impaired when DNA synthesis is blocked

Gottifredi, V., Shieh, S.-Y., Taya, Y., & Prives, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1036 · Cited by 147 · see citing works

Regulation of p21WAF1/CIP1 Stability by WISp39, a Hsp90 Binding TPR Protein

Jascur, T., Brickner, H., Salles-Passador, I., Barbier, V., El Khissiin, A., Smith, B., Fotedar, R., & Fotedar, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.049 · Cited by 145 · see citing works

Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts

Baus, F., Gire, V., Fisher, D., Piette, J., & Dulić, V. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg387 · Cited by 143 · see citing works

p53-dependent Down-regulation of Telomerase Is Mediated by p21

Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402502200 · Cited by 133 · see citing works

Distinct mechanisms act in concert to mediate cell cycle arrest

Toettcher, J. E., Loewer, A., Ostheimer, G. J., Yaffe, M. B., Tidor, B., & Lahav, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806196106 · Cited by 112 · see citing works

DNA repair and aging: The impact of the p53 family

Nicolai, S., Rossi, A., Di Daniele, N., Melino, G., Annicchiarico-Petruzzelli, M., & Raschellà, G. (2015) · Aging · doi:10.18632/aging.100858 · Cited by 118 · see citing works

The G₂ Checkpoint Is Maintained by Redundant Pathways

Passalaris, T. M., Benanti, J. A., Gewin, L., Kiyono, T., & Galloway, D. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.5872 · Cited by 116 · see citing works

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

Mansilla, S. F., De La Vega, M. B., Calzetta, N. L., Siri, S. O., & Gottifredi, V. (2020) · Genes · doi:10.3390/genes11060593 · Cited by 114 · see citing works

p53 can repress transcription of cell cycle genes through a p21^WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

Quaas, M., Müller, G. A., & Engeland, K. (2012) · Cell Cycle · doi:10.4161/cc.22917 · Cited by 107 · see citing works

TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression

Wang, S., Zhang, Y., Huang, J., Wong, C. C., Zhai, J., Li, C., Wei, G., Zhao, L., Wang, G., Wei, H., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3614 · Cited by 104 · see citing works

p130/E2F4 Binds to and Represses the cdc2 Promoter in Response to p53

Taylor, W. R., Schönthal, A. H., Galante, J., & Stark, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005101200 · Cited by 110 · see citing works

Cdk2 is required for p53-independent G2/M checkpoint control

Chung, J. H., & Bunz, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000863 · Cited by 105 · see citing works

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

Soria, G., Speroni, J., Podhajcer, O. L., Prives, C., & Gottifredi, V. (2008) · Journal of Cell Science · doi:10.1242/jcs.027730 · Cited by 94 · see citing works

p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2

Jackson, M. W., Agarwal, M. K., Yang, J., Bruss, P., Uchiumi, T., Agarwal, M. L., Stark, G. R., & Taylor (2005) · Journal of Cell Science · doi:10.1242/jcs.02307 · Cited by 92 · see citing works

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites

Ray, A., Milum, K., Battu, A., Wani, G., & Wani, A. A. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.01.003 · Cited by 85 · see citing works

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

Wei, W., Herbig, U., Wei, S., Dutriaux, A., & Sedivy, J. M. (2003) · The EMBO Reports · doi:10.1038/sj.embor.7400001 · Cited by 88 · see citing works

B-MYB Is Required for Recovery from the DNA Damage–Induced G2 Checkpoint in p53 Mutant Cells

Mannefeld, M., Klassen, E., & Gaubatz, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4156 · Cited by 82 · see citing works

HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis

Ryu, H.-W., Shin, D.-H., Lee, D. H., Choi, J., Han, G., Lee, K. Y., & Kwon, S. H. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.01.033 · Cited by 82 · see citing works

The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators

Crawford, D. F., & Piwnica-Worms, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103414200 · Cited by 79 · see citing works

Epidermal stem cells are resistant to cellular aging

Stern, M. M., & Bickenbach, J. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00318.x · Cited by 79 · see citing works

Wip1 confers G2 checkpoint recovery competence by counteracting p53‐dependent transcriptional repression

Lindqvist, A., de Bruijn, M., Macurek, L., Brás, A., Mensinga, A., Bruinsma, W., Voets, O., Kranenburg, O., & Medema, R. H. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.246 · Cited by 75 · see citing works

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Origanti, S., Cai, S.-R., Munir, A. Z., White, L. S., & Piwnica-Worms, H. (2013) · Oncogene · doi:10.1038/onc.2012.84 · Cited by 74 · see citing works

Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis

Li, X.-H., Chen, X.-J., Ou, W.-B., Zhang, Q., Lv, Z.-R., Zhan, Y., Ma, L., Huang, T., Yan, Y.-B., & Zhou, H.-M. (2013) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2013.02.003 · Cited by 74 · see citing works

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation

Tabach, Y., Milyavsky, M., Shats, I., Brosh, R., Zuk, O., Yitzhaky, A., Mantovani, R., Domany, E., Rotter, V., & Pilpel, Y. (2005) · Molecular Systems Biology · doi:10.1038/msb4100030 · Cited by 72 · see citing works

DNA Damage Triggers p21^WAF1-dependent Emi1 Down-Regulation That Maintains G2 Arrest

Lee, J., Kim, J. A., Barbier, V., Fotedar, A., & Fotedar, R. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-08-0818 · Cited by 68 · see citing works

DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors

Yun, U. J., Park, S. E., Jo, Y. S., Kim, J., & Shin, D. Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.003 · Cited by 69 · see citing works

Computerized Video Time-Lapse Microscopy Studies of Ionizing Radiation-Induced Rapid-Interphase and Mitosis-Related Apoptosis in Lymphoid Cells

Endlich, B., Radford, I. R., Forrester, H. B., & Dewey, W. C. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)153[0036:cvtlms]2.0.co;2 · Cited by 66 · see citing works

Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53

Calvisi, D. F., Simile, M. M., Ladu, S., Frau, M., Evert, M., Tomasi, M. L., Demartis, M. I., Daino, L., Seddaiu, M. A., Brozzetti, S., et al. (2011) · Hepatology · doi:10.1002/hep.24174 · Cited by 65 · see citing works

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

Rossi, M., Demidov, O. N., Anderson, C. W., Appella, E., & Mazur, S. J. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn888 · Cited by 57 · see citing works

p21 promotes error-free replication-coupled DNA double-strand break repair

Mauro, M., Rego, M. A., Boisvert, R. A., Esashi, F., Cavallo, F., Jasin, M., & Howlett, N. G. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks612 · Cited by 56 · see citing works

4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway

Chaudhary, P., Sharma, R., Sahu, M., Vishwanatha, J. K., Awasthi, S., & Awasthi, Y. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467662 · Cited by 55 · see citing works

Residual Cdk1/2 activity after DNA damage promotes senescence

Müllers, E., Silva Cascales, H., Burdova, K., Macurek, L., & Lindqvist, A. (2017) · Aging Cell · doi:10.1111/acel.12588 · Cited by 56 · see citing works

Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression

Müller, G. A., Stangner, K., Schmitt, T., Wintsche, A., & Engeland, K. (2017) · Oncotarget · doi:10.18632/oncotarget.10888 · Cited by 48 · see citing works

p53-mediated heterochromatin reorganization regulates its cell fate decisions.

Mungamuri, S. K., Benson, E. K., Wang, S., Gu, W., Lee, S. W., & Aaronson, S. A. (2012) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2271 · Cited by 53 · see citing works

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

Mansilla, S. F., Soria, G., Vallerga, M. B., Habif, M., Martinez-Lopez, W., Prives, C., & Gottifredi, V. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt475 · Cited by 50 · see citing works

Anti‐leukaemic effects induced by APR‐246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells

Ali, D., Mohammad, D. K., Mujahed, H., Jonson‐Videsäter, K., Nore, B., Paul, C., & Lehmann, S. (2016) · British Journal of Haematology · doi:10.1111/bjh.14036 · Cited by 49 · see citing works

Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth

Bhonde, M. R., Hanski, M.-L., Notter, M., Gillissen, B. F., Daniel, P. T., Zeitz, M., & Hanski, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209017 · Cited by 47 · see citing works

PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells

Sheng, C., Mendler, I.-H., Rieke, S., Snyder, P., Jentsch, M., Friedrich, D., Drossel, B., & Loewer, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.031 · Cited by 45 · see citing works

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

Mansilla, S. F., Bertolin, A. P., Bergoglio, V., Pillaire, M.-J., González Besteiro, M. A., Luzzani, C., Miriuka, S. G., Cazaux, C., Hoffmann, J.-S., & Gottifredi, V. (2016) · eLife · doi:10.7554/elife.18020 · Cited by 43 · see citing works

Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity

Sriraman, A., Radovanovic, M., Wienken, M., Najafova, Z., Li, Y., & Dobbelstein, M. (2016) · Oncotarget · doi:10.18632/oncotarget.9302 · Cited by 44 · see citing works

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

Ceder, S., Eriksson, S. E., Cheteh, E. H., Dawar, S., Corrales Benitez, M., Bykov, V. J. N., Fujihara, K. M., Grandin, M., Li, X., Ramm, S., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.201910852 · Cited by 41 · see citing works

p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P., & Ryan, K. M. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1191714 · Cited by 31 · see citing works

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775

Hauge, S., Macurek, L., & Syljuåsen, R. G. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1593649 · Cited by 30 · see citing works

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

Lee, M., Kim, H., Kim, M.-A., Jee, H. J., Kim, A. J., Bae, Y., Park, J., Chung, J. H., & Yun, J. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6551 · Cited by 65 · see citing works

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Chaturvedi, P., Eng, W.-K., Zhu, Y., Mattern, M. R., Mishra, R., Hurle, M. R., Zhang, X., Annan, R. S., Lu, Q., Faucette, L. F., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202925 · Cited by 420 · see citing works

The Fission Yeast Rad32(Mre11)–Rad50–Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint

Willis, N. A., & Rhind, N. (2010) · Genetics · doi:10.1534/genetics.109.113019 · Cited by 8 · see citing works

Chapter 16 Chk1 and Chk2 as Checkpoint Targets

Zhang, H., Xiao, Z., & Sowin, T. (2009)

Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1

den Elzen, N. R., & O'Connell, M. J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600105 · Cited by 102 · see citing works