Lens development and crystallin gene expression: many roles for Pax‐6

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573

Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene

Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & van Heyningen, V. (1992) · Nature · doi:10.1038/355750a0 · Cited by 1,270

Pax-6, a murine paired box gene, is expressed in the developing CNS

Walther, C., & Gruss, P. (1991) · Development · doi:10.1242/dev.113.4.1435 · Cited by 1,255

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & Heyningen, V. V. (1991) · Nature · doi:10.1038/354522a0 · Cited by 1,158

Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans

Quiring, R., Walldorf, U., Kloter, U., & Gehring, W. J. (1994) · Science · doi:10.1126/science.7914031 · Cited by 1,100

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

Hodgkinson, C. A., Moore, K. J., Nakayama, A., Steingrímsson, E., Copeland, N. G., Jenkins, N. A., & Arnheiter, H. (1993) · Cell · doi:10.1016/0092-8674(93)90429-t · Cited by 1,094

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

Ton, C. C. T., Hirvonen, H., Miwa, H., Weil, M. M., Monaghan, P., Jordan, T., van Heyningen, V., Hastie, N. D., Meijers-Heijboer, H., Drechsler, M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90284-6 · Cited by 862

LENS CRYSTALLINS: THE EVOLUTION AND EXPRESSION OF PROTEINS FOR A HIGHLY SPECIALIZED TISSUE

Wistow, G. J., & Piatigorsky, J. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.002403 · Cited by 778

Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

Lohnes, D., Mark, M., Mendelsohn, C., Dollé, P., Dierich, A., Gorry, P., Gansmuller, A., & Chambon, P. (1994) · Development · doi:10.1242/dev.120.10.2723 · Cited by 764

PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

Glaser, T., Jepeal, L., Edwards, J. G., Young, S. R., Favor, J., & Maas, R. L. (1994) · Nature Genetics · doi:10.1038/ng0894-463 · Cited by 713

Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation

Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A., & Brûlet, P. (1995) · Development · doi:10.1242/dev.121.10.3279 · Cited by 702

Mouse Otx2 functions in the formation and patterning of rostral head.

Matsuo, I., Kuratani, S., Kimura, C., Takeda, N., & Aizawa, S. (1995) · Genes & Development · doi:10.1101/gad.9.21.2646 · Cited by 690

Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

Kastner, P., Grondona, J. M., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J.-L., Dollé, P., & Chambon, P. (1994) · Cell · doi:10.1016/0092-8674(94)90274-7 · Cited by 682

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development

Oliver, G., Mailhos, A., Wehr, R., Copeland, N. G., Jenkins, N. A., & Gruss, P. (1995) · Development · doi:10.1242/dev.121.12.4045 · Cited by 674

The role of Pax-6 in eye and nasal development

Grindley, J. C., Davidson, D. R., & Hill, R. E. (1995) · Development · doi:10.1242/dev.121.5.1433 · Cited by 666

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

Glaser, T., Walton, D. S., & Maas, R. L. (1992) · Nature Genetics · doi:10.1038/ng1192-232 · Cited by 656

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M. R., Nigro, V., & Boncinelli, E. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05935.x · Cited by 617

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

Dollé, P., Ruberte, E., Leroy, P., Morriss-Kay, G., & Chambon, P. (1990) · Development · doi:10.1242/dev.110.4.1133 · Cited by 574

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

Dressler, G. R., Deutsch, U., Chowdhury, K., Nornes, H. O., & Gruss, P. (1990) · Development · doi:10.1242/dev.109.4.787 · Cited by 566

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

Ekker, S. C., Ungar, A. R., Greenstein, P., von Kessler, D. P., Porter, J. A., Moon, R. T., & Beachy, P. A. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00185-0 · Cited by 563

A single amino acid can determine the DNA binding specificity of homeodomain proteins

Trelsman, J., Gönczy, P., Vashishtha, M., Harris, E., & Desplan, C. (1989) · Cell · doi:10.1016/0092-8674(89)90038-x · Cited by 522

Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly

Hanson, I. M., Fletcher, J. M., Jordan, T., Brown, A., Taylor, D., Adams, R. J., Punnett, H. H., & van Heyningen, V. (1994) · Nature Genetics · doi:10.1038/ng0294-168 · Cited by 498

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

Simeone, A., Gulisano, M., Acampora, D., Stornaiuolo, A., Rambaldi, M., & Boncinelli, E. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05319.x · Cited by 473

Midline signalling is required for Pax gene regulation and patterning of the eyes

Macdonald, R., Barth, K. A., Xu, Q., Holder, N., Mikkola, I., & Wilson, S. W. (1995) · Development · doi:10.1242/dev.121.10.3267 · Cited by 445

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

Czerny, T., Schaffner, G., & Busslinger, M. (1993) · Genes & Development · doi:10.1101/gad.7.10.2048 · Cited by 390

Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer

Liu, I. S. C., Chen, J.-D., Ploder, L., Vidgen, D., van der Kooy, D., Kalnins, V. I., & Mclnnes, R. R. (1994) · Neuron · doi:10.1016/0896-6273(94)90354-9 · Cited by 383

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.

Epstein, J., Cai, J., Glaser, T., Jepeal, L., & Maas, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37201-0 · Cited by 369

Prox 1, a prospero-related homeobox gene expressed during mouse development

OLIVER, G., SOSAPINEDA, B., GEISENDORF, S., SPANA, E., DOE, C., & GRUSS, P. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90012-m · Cited by 369

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

Epstein, J. A., Glaser, T., Cai, J., Jepeal, L., Walton, D. S., & Maas, R. L. (1994) · Genes & Development · doi:10.1101/gad.8.17.2022 · Cited by 362

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

Treisman, J., Harris, E., & Desplan, C. (1991) · Genes & Development · doi:10.1101/gad.5.4.594 · Cited by 343

Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations

Xu, W., Rould, M. A., Jun, S., Desplan, C., & Pabo, C. O. (1995) · Cell · doi:10.1016/0092-8674(95)90518-9 · Cited by 327

Developmental expression of murine retinoid X receptor (RXR) genes

Dollé, P., Fraulob, V., Kastner, P., & Chambon, P. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90023-x · Cited by 299

DNA-Binding and Transactivation Properties of Pax-6: Three Amino Acids in the Paired Domain Are Responsible for the Different Sequence Recognition of Pax-6 and BSAP (Pax-5)

Czerny, T., & Busslinger, M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2858 · Cited by 297

Pax-6 Is First Expressed in a Region of Ectoderm Anterior to the Early Neural Plate: Implications for Stepwise Determination of the Lens

Li, H.-S., Yang, J.-M., Jacobson, R. D., Pasko, D., & Sundin, O. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1077 · Cited by 295

Involvement of SOX proteins in lens-specific activation of crystallin genes.

Kamachi, Y., Sockanathan, S., Liu, Q., Breitman, M., Lovell-Badge, R., & Kondoh, H. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07357.x · Cited by 235

Multiple functions for Pax6 in mouse eye and nasal development.

Quinn, J. C., West, J. D., & Hill, R. E. (1996) · Genes & Development · doi:10.1101/gad.10.4.435 · Cited by 230

The Msh-like homeobox genes define domains in the developing vertebrate eye

Monaghan, A. P., Davidson, D. R., Sime, C., Graham, E., Baldock, R., Bhattacharya, S. S., & Hill, R. E. (1991) · Development · doi:10.1242/dev.112.4.1053 · Cited by 216

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

Macdonald, R., Xu, Q., Anukampa Barth, K., Mikkola, I., Holder, N., Fjose, A., Krauss, S., & Wilson, S. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90044-2 · Cited by 216

The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation.

Sekido, R., Murai, K., Funahashi, J., Kamachi, Y., Fujisawa-Sehara, A., Nabeshima, Y., & Kondoh, H. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5692 · Cited by 211

Zebrafish pax[zf-a]: a paired box-containing gene expressed in the neural tube.

Krauss, S., Johansen, T., Korzh, V., Moens, U., Ericson, J. U., & Fjose, A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04927.x · Cited by 210

Expression of winged helix genes, BF‐1 and BF‐2, define adjacent domains within the developing forebrain and retina

Hatini, V., Tao, W., & Lai, E. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251010 · Cited by 209

Embryonic lens induction: shedding light on vertebrate tissue determination

Grainger, R. M. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90280-h · Cited by 205

Uchida rat (rSey): a new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant

Fujiwara, M., Uchida, T., Osumi-Yamashita, N., & Eto, K. (1994) · Differentiation · doi:10.1046/j.1432-0436.1994.5710031.x · Cited by 180

Expression of the α‐Crystallin/Small Heat‐Shock Protein/Molecular Chaperone Genes in the Lens and other Tissues

Sax, C. M., & Piatigorsky, J. (1994) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123157.ch5 · Cited by 150

A Complex Array of Positive and Negative Elements Regulates the Chicken αΑ-Crystallin Gene: Involvement of Pax-6, USF, CREB and/or CREM, and AP-1 Proteins

Cvekl, A., Sax, C. M., Bresnick, E. H., & Piatigorsky, J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7363 · Cited by 147

Lens Crystallins of Invertebrates: Diversity and Recruitment from Detoxification Enzymes and Novel Proteins

Tomarev, S. I., & Piatigorsky, J. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00449.x · Cited by 146

Lens crystallins. Innovation associated with changes in gene regulation.

Piatigorsky, J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42826-8 · Cited by 144

Chicken homeobox gene prox 1 related toDrosophila prospero is expressed in the developing lens and retina

Tomarev, S. I., Sundin, O. H., Banerjee‐Basu, S., Duncan, M. K., Yang, J.-M., & Piatigorsky, J. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199608)206:4<354::aid-aja2>3.0.co;2-h · Cited by 140

Pax-6 is essential for lens-specific expression of zeta-crystallin.

Richardson, J. C., Cvekl, A., & Wistow, G. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4676 · Cited by 135

Transcriptional Regulation of the Mouse αA-Crystallin Gene: Activation Dependent on a Cyclic AMP-Responsive Element (DE1/CRE) and a Pax-6-Binding Site

Cvekl, A., Kashanchi, F., Sax, C. M., Brady, J. N., & Piatigorsky, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.653 · Cited by 128

Vertebrate eye development

Saha, M. S., Servetnick, M. D., & Grainger, R. M. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80176-5 · Cited by 118

Characterization of Quail Pax-6 (Pax-QNR) Proteins Expressed in the Neuroretina

Carrière, C., Plaza, S., Martin, P., Quatannens, B., Bailly, M., Stéhelin, D., & Saule, S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7257-7266.1993 · Cited by 109

Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene.

Cvekl, A., Sax, C. M., Li, X., McDermott, J. B., & Piatigorsky, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4681 · Cited by 105

Functional Interactions between Retinoic Acid Receptor-related Orphan Nuclear Receptor (RORα) and the Retinoic Acid Receptors in the Regulation of the γF-Crystallin Promoter

Tini, M., Fraser, R., & Giguère, V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.20156 · Cited by 100

Characterization of a paired box- and homeobox-containing quail gene (Pax-QNR) expressed in the neuroretina.

Martin, P., Carrière, C., Dozier, C., Quatannens, B., Ma, M., Vandenbunder, B., Stéhelin, D., & Saule, S. (1992) · PubMed · Cited by 97

Quail Pax-6 (Pax-QNR) encodes a transcription factor able to bind and trans-activate its own promoter.

Plaza, S., Dozier, C., & Saule, S. (1993) · PubMed · Cited by 94

Regulation of the Murine αB-Crystallin/Small Heat Shock Protein Gene in Cardiac Muscle

Gopal-Srivastava, R., Haynes, J. I., & Piatigorsky, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.7081 · Cited by 77

Expression of LIM Class Homeobox Gene Xlim-3 in Xenopus Development Is Limited to Neural and Neuroendocrine Tissues

Taira, M., Hayes, W. P., Otani, H., & Dawid, I. B. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1237 · Cited by 74

Spatial and temporal activity of the αB-crystallin/small heat shock protein gene promoter in transgenic mice

Haynes, J. I., Duncan, M. K., & Piatigorsky, J. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199609)207:1<75::aid-aja8>3.0.co;2-t · Cited by 69

The cooperative interaction between two motifis of an enhancer element of the chicken αA-crystallin gene, αCE1 and αCE2, confers lens-specific expression

Matsuo, I., & Yasuda, K. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.14.3701 · Cited by 66

Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro.

Pituello, F., Yamada, G., & Gruss, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6952 · Cited by 63

Developmental regulation of the chicken βB1-crystallin promoter in transgenic mice

Duncan, M. K., Li, X., Ogino, H., et al. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00533-3 · Cited by 61

Nuclear localization signals, DNA binding, and transactivation properties of quail Pax-6 (Pax-QNR) isoforms.

Carrière, C., Plaza, S., Caboche, J., Dozier, C., Bailly, M., Martin, P., & Saule, S. (1995) · PubMed · Cited by 54

Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode

Xu, P.-X., Woo, I., Her, H., Beier, D. R., & Maas, R. L. (1997) · Development · doi:10.1242/dev.124.1.219 · Cited by 331

The last common bilaterian ancestor

Erwin, D. H., & Davidson, E. H. (2002) · Development · doi:10.1242/dev.129.13.3021 · Cited by 320

Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding

Xu, H. E., Rould, M. A., Xu, W., Epstein, J. A., Maas, R. L., & Pabo, C. O. (1999) · Genes & Development · doi:10.1101/gad.13.10.1263 · Cited by 310

Induction of Lens Differentiation by Activation of a bZIP Transcription Factor, L-Maf

Ogino, H., & Yasuda, K. (1998) · Science · doi:10.1126/science.280.5360.115 · Cited by 279

Distinctcis-Essential Modules Direct the Time–Space Pattern of thePax6Gene Activity

Kammandel, B., Chowdhury, K., Stoykova, A., Aparicio, S., Brenner, S., & Gruss, P. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9128 · Cited by 279