The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation
Abstract
We have replaced part of the mouse homeogene Otx2 coding region with the E. coli lacZ coding sequence, thus creating a null allele of Otx2. By 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions. From the early to mid-streak stages, endomesodermal cells expressing lacZ fail to be properly localized anteriorly. In the ectodermal layer, lacZ transcription is progressively extinguished, being barely detectable by the late streak stage. These data suggest that Otx2 expression in endomesoderm and ectoderm is required for anterior neuroectoderm specifi-cation. In gastrulating heterozygous embryos, a post-tran-scriptional repression acts on lacZ transcripts in the ectoderm, but not in the external layer, suggesting that different post-transcriptional mechanisms control Otx2 expression in both layers.
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Cites
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
Morphogenesis of the murine node and notochordal plate
Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K., & Schoenwolf, G. C. (1994) · Developmental Dynamics · doi:10.1002/aja.1002010309 · Cited by 338
Cited by
Molecular diversity of midbrain development in mouse, human, and stem cells
La Manno, G., Gyllborg, D., Codeluppi, S., Nishimura, K., Salto, C., Zeisel, A., Borm, L. E., Stott, S. R. W., Toledo, E. M., Villaescusa, J. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.027 · Cited by 835
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759
Thomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528
Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M., & De Robertis, E. M. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00125-1 · Cited by 460
Szeto, D. P., Rodriguez-Esteban, C., Ryan, A. K., O'Connell, S. M., Liu, F., Kioussi, C., Gleiberman, A. S., Izpisua-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.4.484 · Cited by 426
Metadata
- Authors
- Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A., & Brûlet, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-10-01
- Volume
- 121
- Issue
- 10
- Pages
- 3279-3290
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2183066763
- Cited by
- 702
- References
- 2
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation. https://app.cochat.ai/papers/10.1242/dev.121.10.3279
- The paper
- Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A., & Brûlet, P. (1995). Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. https://doi.org/10.1242/dev.121.10.3279
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