Anti-stress effects of DHA
Abstract
DHA is abundant in the brain. Deficiency of DHA changes behavior in animals. The purpose of the present studies was to clarify the effect of DHA intake on hostility and plasma catecholamines. In study 1, forty-one students took either DHA-rich oil capsules containing 1.5-1.8 g DHA/d (17 females and 5 males) or control oil capsules containing 97% soybean oil plus 3% fish oil (12 females and 7 males) for 3 mon in a double blind fashion. They took a psychological test (P-F Study) at the start and end of the study. Study I started at the end of summer vacation and ended in the middle of mental stress of final exams. In the control group, hostility measured by P-F Study was significantly increased at the end of the study as compared with that measured at the start (+58%), whereas it was not significantly changed in the DHA group (-14%). In a similar double blind two-mon study (study 2), we measured plasma catecholamines and cortisol of students (3 females and 4 males for the DHA group and the same numbers for the control) at the start and end of the study. In study 2 the students were under a continuous stress of final exams that lasted for two mon throughout the whole study period. The plasma cortisol did not change in either group, but the norepinephrine concentration was significantly decreased in the DHA group (-31%), whereas it stayed at the same level in the control group. These effects of DHA intake may be applied to people under psychological stress.
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ω-3 fatty acids have benefits for central functioning ranging from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity.
“The benefits of ω-3 (n-3) fatty acids for central functioning range from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity (131-138).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [134]
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- Authors
- Hamazaki, T., Itomura, M., Sawazaki, S., & Nagao, Y.
- Affiliations
- Institute of Natural Medicine, University of Toyama (JP)
- University of Toyama (JP)
- Kogakkan University (JP)
- Corresponding author
- Hamazaki, Tomohito
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2000-01
- Volume
- 13
- Issue
- 1-4
- Pages
- 41-45
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2128674797
- Cited by
- 53
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Agency
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- docosahexaenoic acid, omega-3 fatty acids, psychological stress, hostility, plasma catecholamines, norepinephrine, cortisol, students, dietary supplementation, P-F study
- MeSH terms
- Adult, Animals, Docosahexaenoic Acids, Double-Blind Method, Epinephrine, Female, Hostility, Humans, Male, Norepinephrine, Psychological Tests, Stress, Psychological
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