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Strain stiffening in collagen I networks
Abstract
Biopolymer gels exhibit strain stiffening that is generally not seen in synthetic gels. Here, we investigate the strain‐stiffening behavior in collagen I gels that demonstrate elasticity derived from a variety of sources including crosslinking through telopeptides, bundling through low‐temperature gelation, and exogenous crosslinking with genipin. In all cases, it is found that these gels exhibit strain stiffening; in general, onset of strain stiffening occurs earlier, yield strain is lower, and degree of strain stiffening is smaller in higher concentration gels and in those displaying thick fibril bundles. Recovery after exposure to high strains is substantial and similar in all gels, suggesting that much of the stiffening comes from reversible network deformations. A key finding of this study is that collagen I gels of identical storage and loss moduli may display different nonlinear responses and different capacities to recover from high strain. © 2012 Wiley Periodicals, Inc.
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Cited by
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Soft network composite materials with deterministic and bio-inspired designs
Jang, K.-I., Chung, H. U., Xu, S., Lee, C. H., Luan, H., Jeong, J., Cheng, H., Kim, G.-T., Han, S. Y., Lee, J. W., et al. (2015) · Nature Communications · doi:10.1038/ncomms7566 · Cited by 533
Advanced Collagen‐Based Biomaterials for Regenerative Biomedicine
Lin, K., Zhang, D., Macedo, M. H., Cui, W., Sarmento, B., & Shen, G. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201804943 · Cited by 373
Ultra-responsive soft matter from strain-stiffening hydrogels
Jaspers, M., Dennison, M., Mabesoone, M. F. J., MacKintosh, F. C., Rowan, A. E., & Kouwer, P. H. J. (2014) · Nature Communications · doi:10.1038/ncomms6808 · Cited by 255
Programmable and contractile materials through cell encapsulation in fibrous hydrogel assemblies
Davidson, M. D., Prendergast, M. E., Ban, E., Xu, K. L., Mickel, G., Mensah, P., Dhand, A., Janmey, P. A., Shenoy, V. B., & Burdick, J. A. (2021) · Science Advances · doi:10.1126/sciadv.abi8157 · Cited by 101
Metadata
- Authors
- Motte, S., & Kaufman, L. J.
- Venue
- Biopolymers
- Publisher
- Wiley
- Published
- 2012-10-23
- Volume
- 99
- Issue
- 1
- Pages
- 35-46
- ISSN
- 0006-3525 (ISSN-L)
- 1097-0282
- OpenAlex
- W1985012152
- Cited by
- 181
- References
- 0
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
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